5,7-diethoxy-6-methoxy-2-phenyl-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5,7-diethoxy-6-methoxy-2-phenyl-chromen-4-one
• 英文别名: 5,7-Diaethoxy-6-methoxy-2-phenyl-chromen-4-on；5,7-Diethoxy-6-methoxy-2-phenylchromen-4-one
• 化学式: C₂₀H₂₀O₅
• 分子量: 340.376
• InChiKey: IWAIZEWVBULHQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  硫酸二乙酯 、 千层纸素A 在 potassium carbonate 、 丙酮 作用下， 生成 5,7-diethoxy-6-methoxy-2-phenyl-chromen-4-one
  参考文献：
  名称：

  Row et al., Proceedings - Indian Academy of Sciences, Section A, 1948, # 28, p. 189,191

  摘要：

  DOI：

文献信息

• Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents
  作者：K. Suresh Babu、T. Hari Babu、P.V. Srinivas、B.S. Sastry、K. Hara Kishore、U.S.N. Murty、J. Madhusudana Rao

  DOI：10.1016/j.bmcl.2005.05.045

  日期：2005.9

  A series of Oroxylin A derivatives, prepared by alkylation and condensation, were fully characterized by spectroscopic methods. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that acylation of 7-OH group in Oroxylin A significantly enhanced the activity as compared to their parent compound (Oroxylin A).
• Row et al., Proceedings - Indian Academy of Sciences, Section A, 1948, # 28, p. 189,191
  作者：Row et al.

  DOI：——

  日期：——