methyl 8-hydroxy-2-(methoxycarbonyl)octanoate | 292157-50-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 8-hydroxy-2-(methoxycarbonyl)octanoate
• 英文别名: dimethyl 2-(6-hydroxyhexyl)propanedioate
• CAS: 292157-50-7
• 化学式: C₁₁H₂₀O₅
• 分子量: 232.277
• InChiKey: OPRGEKRHMSUWBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 8-hydroxy-2-(methoxycarbonyl)octanoate 在 caesium carbonate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of macro-heterocycles structurally related to tirofiban

  摘要：

  Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18- or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)00709-7
• 作为产物：
  描述：

  6-(tetrahydro-2H-pyranyloxy)hexan-1-ol 在 4-甲基苯磺酸吡啶 、 三苯基膦 、 偶氮二甲酸二乙酯 、 碘甲烷 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 生成 methyl 8-hydroxy-2-(methoxycarbonyl)octanoate
  参考文献：
  名称：

  Design and synthesis of macro-heterocycles structurally related to tirofiban

  摘要：

  Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18- or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)00709-7

文献信息

• [EN] LUMINESCENT LANTHANIDE (III) CHELATES, CHELATING AGENTS AND CONJUGATES DERIVED THEREOF<br/>[FR] CHÉLATES LANTHANIDES (III) LUMINESCENTS, AGENTS CHÉLATEURS ET CONJUGUÉS DÉRIVÉS DE CES DERNIERS
  申请人：WALLAC OY

  公开号：WO2009030819A1

  公开（公告）日：2009-03-12

  This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained. The chelates described herein compris - a lanthanide ion, Ln 3+ - chromophoric moiety - a chelating part, and - a reactive group.

  该发明涉及一组新型螯合剂、新型螯合物、用所述螯合物或螯合剂标记的生物分子，以及与所述螯合物、螯合剂或标记的生物分子结合的固体支持物。特别是该发明涉及在寡核苷酸或寡肽的固相合成中有用的新型螯合剂，以及由此获得的寡核苷酸和寡肽。这里描述的螯合物包括- 镧系离子，Ln 3+ - 显色基团 - 螯合部分和 - 反应性基团。
• Luminescent lanthanide (III) chelates, chelating agents and conjugates derived thereof
  申请人：Peuralahti Jari

  公开号：US20100204442A1

  公开（公告）日：2010-08-12

  This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.

  本发明涉及一组新型螯合剂、新型螯合物、用所述螯合剂或螯合物标记的生物分子以及与所述螯合剂、螯合物或标记生物分子共轭的固体支持物。特别地，本发明涉及在寡核苷酸或寡肽的固相合成中有用的新型螯合剂以及由此获得的寡核苷酸和寡肽。
• LUMINESCENT LANTHANIDE (III) CHELATES, CHELATING AGENTS AND CONJUGATES DERIVED THEREOF
  申请人：Wallac OY

  公开号：EP2195310A1

  公开（公告）日：2010-06-16
• US8221719B2
  申请人：——

  公开号：US8221719B2

  公开（公告）日：2012-07-17
• Design and synthesis of macro-heterocycles structurally related to tirofiban
  作者：Mahesh Ramaseshan、Martin Robitaille、John W Ellingboe、Yves L Dory、Pierre Deslongchamps

  DOI：10.1016/s0040-4039(00)00709-7

  日期：2000.6

  Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18- or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence. (C) 2000 Published by Elsevier Science Ltd.