毒理性
哺乳期使用概述：氟轻松在哺乳期间并未进行研究。由于只有大量使用最强效的皮质类固醇才可能在母亲体内产生系统性影响，因此短期使用外用皮质类固醇不太可能通过进入母乳而对哺乳婴儿构成风险。然而，使用最小面积皮肤上可能的最小效力药物将是谨慎的做法。特别是要确保婴儿的皮肤不直接接触到已经治疗的皮肤区域。只有在乳头或乳晕上使用低效力的皮质类固醇，因为婴儿可能会直接从皮肤上摄取药物。应该只用水溶性乳膏或凝胶产品涂抹乳房，因为软膏可能会使婴儿通过舔舐接触到高水平的矿物石蜡。如果外用皮质类固醇应用于乳房或乳头区域，应在哺乳前彻底擦除。
母亲使用含有氟轻松的耳滴或眼内植入物对哺乳婴儿的风险微乎其微。主要专家共识认为，氟轻松醋酸植入物可以用于哺乳期母亲的糖尿病性黄斑水肿治疗。
对哺乳婴儿的影响：将具有相对较高盐皮质激素活性的皮质类固醇（异氟泼尼松醋酸）涂在母亲的乳头上，导致她的2个月大的哺乳婴儿出现QT间期延长、库欣样外观、严重高血压、生长减缓和电解质异常。这位母亲从出生起就因为乳头疼痛而使用该乳膏。
对泌乳和母乳的影响：截至修订日期，未找到相关的已发布信息。
◉ Summary of Use during Lactation:Fluocinolone has not been studied during breastfeeding. Since only extensive application of the most potent corticosteroids may cause systemic effects in the mother, it is unlikely that short-term application of topical corticosteroids would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only the lower potency corticosteroids should be used on the nipple or areola where the infant could directly ingest the drugs from the skin. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking. Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is being applied to the breast or nipple area.
Maternal use of an ear drop or eye insert that contains fluocinolone presents negligible risk for the nursing infant. The predominant expert consensus is that fluocinolone acetonide implants can be used for diabetic macular edema in nursing mothers.
◉ Effects in Breastfed Infants:Topical application of a corticosteroid with relatively high mineralocorticoid activity (isofluprednone acetate) to the mother's nipples resulted in prolonged QT interval, cushingoid appearance, severe hypertension, decreased growth and electrolyte abnormalities in her 2-month-old breastfed infant. The mother had used the cream since birth for painful nipples.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
