(4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-8-(4-benzylphenyl)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one | 1159113-30-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-8-(4-benzylphenyl)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• 英文别名: (1S,2S,4R,6R,8S,9S,11S,12R,13S,19S)-6-(4-benzylphenyl)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
• CAS: 1159113-30-0
• 化学式: C₃₅H₃₆F₂O₆
• 分子量: 590.664
• InChiKey: NRTDTGFGTBFMPP-BFQQSILCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  43
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  醋酸氟轻松 在 tetrafluoroboric acid 、 三氟甲磺酸 、 magnesium sulfate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 2.0h， 生成 (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-8-(4-benzylphenyl)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  参考文献：
  名称：

  Kilogram-Scale Synthesis of an Inhaled Corticosteroid

  摘要：

  The development and implementation of a safe and scalable process for the manufacture of corticosteroid PF-4714224 (1) is described. Initial routes used to synthesise analogues from this series directly from fluocinolone acetonide (2) were unsuitable for large-scale use. Key aspects of the route are the efficient and simple method for the preparation of the steroid tetraol (6), acetal formation by reaction of the tetraol with a bisulphite adduct (12), and isolation of the product by sequential recrystallisations.

  DOI：

  10.1021/op200257g

文献信息

• GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF
  申请人：AbbVie Inc.

  公开号：US20190167804A1

  公开（公告）日：2019-06-06

  Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same.

  提供的是糖皮质激素受体激动剂免疫偶联物，糖皮质激素受体激动剂，以及使用它们的方法。
• Novel Glucocorticoid Receptor Agonists
  申请人：Glossop Paul Alan

  公开号：US20090227548A1

  公开（公告）日：2009-09-10

  This Invention Relates To Novel Glucocorticoid Receptor Agonists of Formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their use for the treatment of a number of inflammatory and allergic diseases, disorders and conditions.

  本发明涉及一种新型的糖皮质激素受体激动剂，其化学式为(I)，以及用于其制备的工艺和中间体。本发明还涉及含有这些化合物的制药组合物，以及它们与一个或多个其他治疗剂的联合使用，以治疗多种炎症和过敏性疾病、紊乱和病况。
• NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS
  申请人：Pfizer Inc.

  公开号：US20140336160A1

  公开（公告）日：2014-11-13

  This invention relates to novel glucocorticoid receptor agonists of formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their use for the treatment of a number of inflammatory and allergic diseases, disorders and conditions.

  本发明涉及一种新型糖皮质激素受体激动剂，其化学式为（I），以及其制备过程和中间体。本发明还涉及含有这些化合物的制药组合物，以及它们与一种或多种其他治疗剂的组合，以及它们用于治疗多种炎症和过敏性疾病、障碍和病况。
• Glucocorticoid receptor agonist and immunoconjugates thereof
  申请人：AbbVie Inc.

  公开号：US10772970B2

  公开（公告）日：2020-09-15

  Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same.

  本文提供了糖皮质激素受体激动剂免疫共轭物、糖皮质激素受体激动剂及其使用方法。
• [EN] NOVEL GLUCOCORTICOID RECEPTOR AGONISTS<br/>[FR] NOUVEAUX AGONISTES DES RÉCEPTEURS DES GLUCOCORTICOÏDES
  申请人：PFIZER LTD

  公开号：WO2009069032A3

  公开（公告）日：2009-08-06