8-methoxy-1-methyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 8-methoxy-1-methyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
• 英文别名: 8-Methoxy-1-methyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione；7-methoxy-5-methyl-1H-1,5-benzodiazepine-2,4-dione
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.228
• InChiKey: VHOADKDEIAZTHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  碘乙烷 、 8-methoxy-1-methyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 oil 为溶剂， 反应 1.0h， 以77%的产率得到1-ethyl-7-methoxy-5-methyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione
  参考文献：
  名称：

  [EN] BENZODIAZEPINE COMPOUND AND PHARMACEUTICAL COMPOSITION
  [FR] COMPOSÉ DE BENZODIAZÉPINE ET COMPOSITION PHARMACEUTIQUE

  摘要：

  本发明提供了一种新型苯二氮卓类化合物，其比其他K+通道更有效地和更选择性地阻断IKur电流或Kv1.5通道或IKACH电流（GIRK1/4通道）。本发明的苯二氮卓类化合物由通用公式（1）表示，其中R1、R2、R3和R4分别独立地为氢或较低的烷基；R2和R3可以连接形成较低的烷基链；A1是较低的烷基链，可选择地取代一个或多个羟基；而R5是一个由所表示的基团，其中R6和R7分别独立地为氢或有机基团；XA和XB分别独立地为键合、较低的烷基链等。

  公开号：

  WO2009104819A1
• 作为产物：
  描述：

  5-甲氧基-N-甲基-3-硝基苯胺 在 palladium on activated charcoal sodium ethanolate 、 sodium hydride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 oil 为溶剂， 60.0 ℃ 、101.33 kPa 条件下， 反应 2.5h， 生成 8-methoxy-1-methyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
  参考文献：
  名称：

  [EN] BENZODIAZEPINE COMPOUND AND PHARMACEUTICAL COMPOSITION
  [FR] COMPOSÉ DE BENZODIAZÉPINE ET COMPOSITION PHARMACEUTIQUE

  摘要：

  本发明提供了一种新型苯二氮卓类化合物，其比其他K+通道更有效地和更选择性地阻断IKur电流或Kv1.5通道或IKACH电流（GIRK1/4通道）。本发明的苯二氮卓类化合物由通用公式（1）表示，其中R1、R2、R3和R4分别独立地为氢或较低的烷基；R2和R3可以连接形成较低的烷基链；A1是较低的烷基链，可选择地取代一个或多个羟基；而R5是一个由所表示的基团，其中R6和R7分别独立地为氢或有机基团；XA和XB分别独立地为键合、较低的烷基链等。

  公开号：

  WO2009104819A1

文献信息

• Benzodiazepine compound and pharmaceutical composition
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US08338406B2

  公开（公告）日：2012-12-25

  The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

  本发明提供了一种新型苯二氮平化合物，它比其他K+通道更具选择性地有效阻断IKur电流或Kv1.5通道。该发明的苯二氮平化合物由通式（1）表示，其中R1、R2、R3和R4各自独立地为氢或低碳基；R2和R3可以连接成低碳烷基；A1是低碳烷基，可以选择性地被一个或多个羟基取代；R5是下述基团：其中R6和R7各自独立地为氢或有机基团；XA和XB各自独立地为键、低碳烷基等。
• NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION
  申请人：Oshima Kunio

  公开号：US20120225866A1

  公开（公告）日：2012-09-06

  The present invention provides a novel diazepine compound that blocks the I Kur current or the Kv1.5 channel potently and more selectively than other K + channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R 2 and R 3 may be linked to form lower alkylene; A 1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y 1 and Y 2 are each independently —N═ or —CH═; and R 5 is group represented by wherein R 6 and R 7 are each independently hydrogen or organic group; R 6 and R 7 may be linked to form a ring together with the neighboring group —X A —N—X B —; X A and X B are each independently a bond, lower alkylene, etc.

  本发明提供了一种新型的二氮杂环化合物，它可以有效地阻断IKur电流或Kv1.5通道，并比其他K+通道更具选择性。本发明涉及一种由通式（1）表示的二氮杂环化合物或其盐，其中R1、R2、R3和R4各自独立地表示氢、低碳基、环状低碳基或低烷氧基低碳基；R2和R3可以连接形成低碳烷基；A1是低碳烷基，可选地取代一个或多个羟基和氧代基；Y1和Y2各自独立地表示—N═或—CH═；R5是由下式表示的基：其中R6和R7各自独立地表示氢或有机基团；R6和R7可以与相邻的基团—XA—N—XB—一起形成环；XA和XB各自独立地表示键、低碳烷基等。
• BENZODIAZEPINE COMPOUND AND PHARMACEUTICAL COMPOSITION
  申请人：Oshima Kunio

  公开号：US20130040941A1

  公开（公告）日：2013-02-14

  The present invention provides a novel benzodiazepine compound that blocks the I Kur current or the Kv1.5 channel potently and more selectively than other K + channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R 1 , R 2 , R 3 , and R 4 are each independently hydrogen or lower alkyl; R 2 and R 3 may be linked to form lower alkylene; A 1 is lower alkylene optionally substituted with one or more hydroxy; and R 5 is group represented by wherein R 6 and R 7 are each independently hydrogen or organic group; X A and X B are each independently bond, lower alkylene, etc.

  本发明提供了一种新型苯二氮平化合物，能够有效地阻断IKur电流或Kv1.5通道，比其他K+通道更具选择性。本发明的苯二氮平化合物由通式（1）表示，其中R1、R2、R3和R4各自独立地为氢或低碳基；R2和R3可以连接形成低碳链；A1为低碳链，可选地取代一个或多个羟基；R5为由下式表示的基团：其中R6和R7各自独立地为氢或有机基团；XA和XB各自独立地为键，低碳链等。
• Nitrogen-containing compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation
  申请人：Matsumura Shuuji

  公开号：US08822453B2

  公开（公告）日：2014-09-02

  The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N═ or —CH═; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

  本发明提供了一种新型二氮杂烷化合物，可比其他K+通道更有效地和更选择性地阻断IKur电流或Kv1.5通道。本发明涉及一种由通式（1）表示的二氮杂烷化合物或其盐，其中R1、R2、R3和R4各自独立地为氢、低碳基、环低碳基或低烷氧基低碳基；R2和R3可以连接形成低碳烷基；A1是低碳烷基，可选地取代一个或多个取代基，所述取代基选择自羟基和氧代基；Y1和Y2各自独立地为—N═或—CH═；以及R5是由以下式子表示的基：其中R6和R7各自独立地为氢或有机基团；R6和R7可以与相邻的基团—XA—N—XB—一起形成环；XA和XB各自独立地为键、低碳烷基等。
• US20140343278A1
  申请人：——

  公开号：——

  公开（公告）日：——