phosphorus (III) oxychloride | 21295-50-1

• 分子结构分类: 无机化合物 - 均质非金属化合物 - 卤代有机物
• 英文名称: phosphorus (III) oxychloride
• 英文别名: phosphorus(III) oxychloride；phosphorus chloride oxide；phosphoryl(III) chloride；phosphoryl chloride；oxyphosphorus chloride；phosphorus oxychloride；Phosphorus monochloride monoxide
• CAS: 21295-50-1
• 化学式: ClOP
• 分子量: 82.4262
• InChiKey: RLOWWWKZYUNIDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  phosphorus (III) oxychloride 在 氧气 作用下， 以 gas 为溶剂， 生成 Phosphoryl oxychloride
  参考文献：
  名称：

  Binnewies, M., Zeitschrift fur Anorganische und Allgemeine Chemie

  摘要：

  DOI：
• 作为产物：
  描述：

  (allyloxy)dichlorophosphine 以 gaseous matrix 为溶剂， 生成 phosphorus (III) oxychloride
  参考文献：
  名称：

  Binnewies, M.; Schnoeckel, H.; Gereke, R., Zeitschrift fur Anorganische und Allgemeine Chemie

  摘要：

  DOI：
• 作为试剂：
  描述：

  鸟苷 在 吡啶 、 phosphorus (III) oxychloride 、 四乙基氯化铵 、 N,N-二甲基苯胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
  参考文献：
  名称：

  A facile synthesis of 2-azidoadenosine derivatives from guanosine as photoaffinity probes

  摘要：

  2-Azidoadenosine (1) was synthesized in an overall yield of 49% from guanosine via the reaction of 9-(2',3',5'-tri-O-acetyl-beta-D-ribofuranosyl)-2-amino-6-chloropurine (2) with isoamyl nitrite and trimethylsilyl azide under neutral and anhydrous conditions. As photoaffinity probes, ATP analogues and the cap structure of eukaryotic mRNA bearing 2-azidoadenosine were synthesized.

  DOI：

  10.1016/0960-894x(95)00548-8

文献信息

• Benzimidazoles useful as angiotensin-11 antagonists
  申请人：Dr. Karl Thomae GmbH

  公开号：US05591762A1

  公开（公告）日：1997-01-07

  Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: (a) 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1-yl] methyl]-biphenyl-2-carboxylic acid.

  本文披露了以下结构的血管紧张素II拮抗剂##STR1##其中R.sub.1是氢以外的其他官能团，包括卤素、较低的烷基或环烷基；R.sub.2是可选择地取代的苯并咪唑-2-基、5,6,7,8-四氢咪唑并[1,2-a]吡啶-2-基、丁磺酰胺-1-基、咪唑-4-基和四氢苯并咪唑-2-基等；R.sub.3是较低的烷基；R.sub.4是酸性基团，如羧基或四唑基。一个示例化合物是：(a) 4'-[[2-正丙基-4-甲基-6-(1-甲基苯并咪唑-2-基)-苯并咪唑-1-基] 甲基]-联苯-2-羧酸。
• Pyrazol-4-acetic acid compounds
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：US04146721A1

  公开（公告）日：1979-03-27

  Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.

  Pyrazol-4-乙酸化合物，例如取代的pyrazol-4-乙酸，其酯，酰胺，腈及其药学上可接受的盐以及制备这些化合物的方法已被披露。这些新颖的化合物可用作镇痛剂，抗炎药和退烧药。
• Phosphinolines and phosphindolines
  申请人：Monash University

  公开号：US03931196A1

  公开（公告）日：1976-01-06

  This invention is for phosphinoline and phosphindoline compounds having the formula, Wherein n is 0 or 1; X is 0 or S; R.sup.3 is hydrogen or methyl; R.sup.5 is hydrogen or methyl, or may be bound to R.sup.13 to form a morpholino, piperidino or pyrrolidino ring; R.sup.7 is hydrogen or hydroxy; R.sup.11 and R.sup.12 are hydrogen; R.sup.13 is methyl, or R.sup.13 and R.sup.5 may be joined together as above stated to form a morpholino, piperidino, or pyrrolidino ring. The compounds are analgesics.

  本发明涉及具有以下式的磷酰胺和磷酰胺化合物，其中n为0或1；X为0或S；R.sup.3为氢或甲基；R.sup.5为氢或甲基，或可与R.sup.13结合形成吗啡啶、哌啶或吡咯啉环；R.sup.7为氢或羟基；R.sup.11和R.sup.12为氢；R.sup.13为甲基，或R.sup.13和R.sup.5可结合形成上述的吗啡啶、哌啶或吡咯啉环。这些化合物是镇痛剂。
• Azo compounds having a 5-substituted-4-chlorothiazolyl-2-diazo component
  申请人：Sandoz Ltd.

  公开号：US04505857A1

  公开（公告）日：1985-03-19

  Compounds of the formula ##STR1## in which K is the radical of a coupling component of the aniline, .alpha.-naphthylamine, pyrazolone, aminopyrazole, indole, tetrahydroquinoline, thiazole, phenol, naphthol, pyridine or pyridone series. R is --CHO, --CH.dbd.C(CN)--R.sub.1, --CH.dbd.CH--R.sub.2, --CH.dbd.C(NO.sub.2)--R.sub.3, --CH.dbd.NOH or --CN, wherein R.sub.1 is (C.sub.1-10 alkoxycarbonyl; (C.sub.1-10 alkoxy)carbonyl monosubstituted by chloro, bromo, cyano, hydroxy, C.sub.1-2 alkoxy, (C.sub.1-2 alkyl)carbonyloxy or (C.sub.1-2 alkoxy)carbonyl; (C.sub.1-10 alkoxy)carbonyl disubstituted by hydroxy and by chloro or bromo; (C.sub.3-8 alkenyl)oxycarbonyl; (C.sub.3-8 chloroalkenyl)oxycarbonyl; (C.sub.3-8 bromoalkenyl)oxycarbonyl; propynyloxycarbonyl; benzyloxycarbonyl; chlorobenzyloxycarbonyl; nitrobenzyloxycarbonyl; C.sub.1-4 alkylsulfonyl; phenylsulfonyl; tolylsulfonyl; carbamoyl; (C.sub.1-2 alkyl)carbamoyl; di(C.sub.1-2 alkyl)carbamoyl; phenylcarbamoyl; aminothiocarbonyl; benzimidazolyl-2; cyano; acetyl; phenyl; benzoyl or phenyl or benzoyl substituted by 1, 2 or 3 substituents each of which is independently chloro, bromo or nitro, with the proviso that the maximum number of nitro groups is two, and R.sub.2 is phenyl; benzoyl or phenyl or benzoyl substituted by 1, 2 or 3 substituents each of which is independently chloro, bromo or nitro, with the proviso that the maximum number of nitro groups is two, and R.sub.3 is hydrogen, methyl or ethyl, and m is 0 or 1, useful as disperse dyes for dyeing and printing textile substrates comprising or consisting of synthetic or semi-synthetic, hydrophobic, high molecular weight, organic materials such as linear aromatic polyesters, cellulose 21/2 acetate, cellulose triacetate and synthetic polyamides, with those wherein R is formyl also being useful for dyeing wool.

  式为##STR1##的化合物，其中K是苯胺，α-萘胺，吡唑酮，氨基吡唑，吲哚，四氢喹啉，噻唑，苯酚，萘酚，吡啶或吡啶酮系列偶联组分的基团。R是--CHO，--CH.dbd.C（CN）--R.sub.1，--CH.dbd.CH--R.sub.2，--CH.dbd.C（NO.sub.2）--R.sub.3，--CH.dbd.NOH或--CN，其中R.sub.1是（C.sub.1-10烷氧羰基；（C.sub.1-10烷氧）羰基单取代为氯，溴，氰，羟基，C.sub.1-2烷氧，（C.sub.1-2烷基）羰酰氧或（C.sub.1-2烷氧）羰基；（C.sub.1-10烷氧）羰基双取代为羟基和氯或溴；（C.sub.3-8烯基）氧羰基；（C.sub.3-8氯代烯基）氧羰基；（C.sub.3-8溴代烯基）氧羰基；丙炔氧羰基；苄氧羰基；氯苄氧羰基；硝基苄氧羰基；C.sub.1-4烷基磺酰基；苯基磺酰基；甲苯基磺酰基；氨基甲酰基；（C.sub.1-2烷基）氨基甲酰基；二（C.sub.1-2烷基）氨基甲酰基；苯基氨基硫酰基；苯并咪唑基-2；氰基；乙酰基；苯基；苯甲酰基或苯基或苯甲酰基，其1，2或3个取代基各自独立地为氯，溴或硝基，最多只有两个硝基的限制，其中R.sub.2是苯基；苯甲酰基或苯基或苯甲酰基，其1，2或3个取代基各自独立地为氯，溴或硝基，最多只有两个硝基的限制，R.sub.3是氢，甲基或乙基，m为0或1，用作分散染料，用于染色和印刷由合成或半合成，亲水性，高分子量，有机材料制成或组成的纺织基材，如线性芳香族聚酯，纤维素21/2醋酸盐，纤维素三醋酸盐和合成聚酰胺，其中R为甲酰基也用于染色羊毛。
• Molecular PO2Cl: matrix IR investigations and ab initio SCF calculations
  作者：R. Ahlrichs、C. Ehrhardt、M. Lakenbrink、S. Schunck、H. Schnoeckel

  DOI：10.1021/ja00273a008

  日期：1986.6

  PO/sub 2/Cl produced by a photochemical reaction between O/sub 3/ and POCl in solid Ar has been studied by IR spectroscopy. The same species is formed in a high-temperature reaction between POCl/sub 3/, O/sub 2/, and Ag. IR spectra including /sup 16/O//sup 18/O and /sup 35/Cl//sup 37/Cl shifts show that the OPO angle is about 135/sup 0/ and that the PCl bond is unexpectedly strong (f(PCl) = 3.7 mdyn

  已通过红外光谱研究了固体 Ar 中 O/sub 3/ 和 POCl 之间的光化学反应产生的 PO/sub 2/Cl。在 POCl/sub 3/、O/sub 2/ 和 Ag 之间的高温反应中形成相同的物种。包括 /sup 16/O//sup 18/O 和 /sup 35/Cl//sup 37/Cl 位移的红外光谱表明 OPO 角约为 135/sup 0/ 并且 PCl 键出乎意料地强（f（ PCl) = 3.7 mdyn A/sup -1/)。这些结果由 ab initio SCF 计算证实。PO/sub 2/Cl 中的键合与类似分子的键合进行了比较。