6-(2-甲氧基-苯基)-[1,3,5]三嗪-2,4-二胺 | 72775-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 6-(2-甲氧基-苯基)-[1,3,5]三嗪-2,4-二胺
• 英文名称: 6-(2-methoxyphenyl)-1,3,5-triazine-2,4-diamine
• 英文别名: 2-<2-Methoxy-phenyl>-4,6-diamino-1,3,5-triazin
• CAS: 72775-80-5
• 化学式: C₁₀H₁₁N₅O
• mdl: MFCD00458225
• 分子量: 217.23
• InChiKey: GKMGVJQSEMDNAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  99.9
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2933699090

反应信息

• 作为反应物：
  描述：

  硝基脲 、 6-(2-甲氧基-苯基)-[1,3,5]三嗪-2,4-二胺 在 硫酸 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以91%的产率得到[4-(Carbamoylamino)-6-(2-methoxyphenyl)-1,3,5-triazin-2-yl]urea
  参考文献：
  名称：

  Synthesis and properties of derivatives of sym-triazine. 5. Synthesis and mass spectrometric study of carbamide derivatives of sym-triazine

  摘要：

  DOI：

  10.1007/bf00761989
• 作为产物：
  描述：

  二聚氰胺 生成 6-(2-甲氧基-苯基)-[1,3,5]三嗪-2,4-二胺
  参考文献：
  名称：

  KALAB, JIRI;MORAVEK, JOSEF

  摘要：

  DOI：

文献信息

• Synthesis, molecular docking studies, and in vitro evaluation of 1,3,5-triazine derivatives as promising antimicrobial agents
  作者：Vikrant Patil、Anurag Noonikara-Poyil、Shrinivas D. Joshi、Shivaputra A. Patil、Siddappa A. Patil、Abby M. Lewis、Alejandro Bugarin

  DOI：10.1016/j.molstruc.2020.128687

  日期：2020.11

  was examined against five bacterial and two fungal strains. In vitro study revealed that the freshly synthesized 6-(thiazol-4-yl)-1,3,5-triazine-2,4-diamine (3o) showed good antibacterial growth inhibition against E. coli, K. pneumoniae, and A. baumannii bacterial strains, and even the fungi C. neoformans. Molecular docking studies were performed on the X-ray crystal structure of E. coli 24 kDa domain

  摘要 六元环杂环1,3,5-三嗪及其衍生物由于被证明是优良的生物活性除草剂、抗癌剂等而备受关注。一系列1,3,5-三嗪衍生物(3a- o) 通过一步反应合成，并通过 1H NMR、13C NMR 和质谱分析进行表征。针对五种细菌和两种真菌菌株检查了标题化合物 (3a-o) 的抗菌筛选。体外研究表明，新合成的 6-(thiazol-4-yl)-1,3,5-triazine-2,4-diamine (3o) 对大肠杆菌、肺炎克雷伯菌和 A . baumannii 细菌菌株，甚至真菌 C. neoformans。对大肠杆菌 24 kDa 结构域与氯霉素（PDB 代码：1KZN；分辨率 2.30 A) 使用 Sybyl-X 软件的 Surflex-Dock 程序。获得的结果非常令人鼓舞。
• BIODEGRADABLE PLASTICS COMPOSITION, MOLDED ARTICLE OF THE COMPOSITION, AND METHOD OF CONTROLLING BIODEGRADATION RATE
  申请人：Takahashi Ikuo

  公开号：US20070265371A1

  公开（公告）日：2007-11-15

  Provided are: a biodegradable plastics composition which controls a biodegradation rate with a synergistic controlling effect on three components, adjusts a hydrolysis rate, and shows significantly improved weatherability; a molded article of the composition; and a method of controlling the biodegradation rate of a biodegradable plastics. The biodegradable plastics composition includes: a biodegradable plastics; and a carbodiimide compound, an ultraviolet ray absorbent, and an antioxidant to be blended as essential ingredients into the biodegradable plastics, and the molded article of the composition is also provided.

  提供的是：一种可生物降解塑料组合物，具有对三个组分的协同控制效应，调节水解速率，并显示显着改善的耐候性；该组合物的成型品；以及控制可生物降解塑料的生物降解速率的方法。可生物降解塑料组合物包括：可生物降解塑料；以及作为必要成分混合到可生物降解塑料中的碳二亚胺化合物、紫外线吸收剂和抗氧化剂，同时还提供该组合物的成型品。
• ANTICANCER COMPOSITION AND COMPOUND
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0563386A1

  公开（公告）日：1993-10-06

  An anticancer composition containing a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof. In formula (I), R¹⁰ and R²⁰ may be the same or different from each other and each represents hydrogen, halogen, amino, aralkylamino, nitro, lower alkyl, lower alkoxy, lower alkoxyalkoxy, lower aralkyloxy or acyl; R³⁰ and R⁴⁰ may be the same or different from each other and each represents hydrogen, nicotinoyl, benzoyl or lower alkoxy; and n represents 0 or 1.

  一种抗癌组合物，含有通式(I)代表的化合物或其药理学上可接受的酸加成盐。在式 (I) 中，R¹⁰ 和 R²⁰ 可以彼此相同或不同，各自代表氢、卤素、氨基、烷基氨基、硝基、低级烷基、低级烷氧基、低级烷氧基烷氧基、低级芳氧基或酰基；R³⁰ 和 R⁴⁰ 可以彼此相同或不同，各自代表氢、烟酰基、苯甲酰基或低级烷氧基；n 代表 0 或 1。
• A biodegradable plastic composition, a molded article thereof and a method for controlling biodegradation rate using the same composition
  申请人：NISSHINBO INDUSTRIES INC.

  公开号：EP1418201A1

  公开（公告）日：2004-05-12

  A biodegradable plastic composition which can be stably adjusted in biodegradation rate, and has greatly improved resistance to hydrolysis and weather, in particular the former, and durability resulting from the improved resistances; a molded article thereof; and a method for controlling biodegradation rate using the same composition. The biodegradable plastic composition comprising (A) 100 parts by weight of biodegradable plastic, (B) 0.01 to 10 parts by weight of a carbodiimide compound and (C) 0.01 to 10 parts by weight of at least one compound selected from the group consisting of benzotriazole-, triazine- and hydroxylamine-based one; the molded article thereof; and the method for controlling biodegradation rate using the same composition.

  一种可生物降解的塑料组合物，它可以稳定地调节生物降解率，并大大提高了抗水解性和耐候性，特别是前者，以及由于抗水解性和耐候性的提高而产生的耐久性；其模压制品；以及使用相同组合物控制生物降解率的方法。生物可降解塑料组合物，包括(A)100 重量份的生物可降解塑料，(B)0.01 至 10 重量份的碳化二亚胺化合物和(C)0.01 至 10 重量份的至少一种选自苯并三唑基、三嗪基和羟胺基化合物组的化合物；其成型品；以及使用相同组合物控制生物降解率的方法。
• Biodegradable plastics composition, molded article of the composition, and method of controlling biodegradation rate
  申请人：Nisshinbo Industries, Inc.

  公开号：EP1854837A2

  公开（公告）日：2007-11-14

  Provided are: a biodegradable plastics composition which controls a biodegradation rate with a synergistic controlling effect on three components, adjusts a hydrolysis rate, and shows significantly improved weatherability; a molded article of the composition; and a method of controlling the biodegradation rate of a biodegradable plastics. The biodegradable plastics composition includes: a biodegradable plastics; and a carbodiimide compound, an ultraviolet ray absorbent, and an antioxidant to be blended as essential ingredients into the biodegradable plastics, and the molded article of the composition is also provided.

  本文提供了：一种可生物降解塑料组合物，该组合物通过对三种成分的协同控制作用来控制生物降解速率，调节水解速率，并显著改善耐候性；一种由该组合物制成的成型品；以及一种控制可生物降解塑料生物降解速率的方法。该可生物降解塑料组合物包括：一种可生物降解塑料；以及一种碳二亚胺化合物、一种紫外线吸收剂和一种抗氧化剂，它们作为基本成分被混合到可生物降解塑料中，同时还提供了该组合物的成型品。