1-乙氧基-2-甲氧基-4-甲基苯 | 33963-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-乙氧基-2-甲氧基-4-甲基苯
• 英文名称: 4-ethoxy-3-methoxytoluene
• 英文别名: 4-ethoxy-3-methoxy-toluene；4-Aethoxy-3-methoxy-toluol；Homobrenzcatechin-3-methylaether-4-aethylaether；3-Methoxy-4-aethoxy-1-methyl-benzol；Kreosolaethylaether；1-Ethoxy-2-methoxy-4-methylbenzene
• CAS: 33963-27-8
• 化学式: C₁₀H₁₄O₂
• mdl: MFCD00210457
• 分子量: 166.22
• InChiKey: QOFRRWWZQIIACS-UHFFFAOYSA-N

物化性质

• 沸点：
  228.4±20.0 °C(Predicted)
• 密度：
  0.976±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-乙氧基-2-甲氧基-4-甲基苯 在 盐酸 、 氢氧化钾 、 三氯化铝 、 silver(l) oxide 、 苯 作用下， 生成 5-ethoxy-4-methoxy-2-methyl-benzoic acid
  参考文献：
  名称：

  Arcoleo; Garofano, Annali di Chimica, 1957, vol. 47, p. 1142,1161

  摘要：

  DOI：
• 作为产物：
  描述：

  4-乙氧基-3-甲氧基苯甲醛 在 palladium on activated charcoal 、 乙醇 作用下， 生成 1-乙氧基-2-甲氧基-4-甲基苯
  参考文献：
  名称：

  Galmarini, Anales des la Asociacion Quimica Argentina, 1951, vol. 39, p. 92,96

  摘要：

  DOI：

文献信息

• [EN] PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS<br/>[FR] AMIDES DE PIPÉRIDINE SPIROCYCLIQUES PYRANES UTILISÉS EN TANT QUE MODULATEURS DE CANAUX IONIQUES
  申请人：VERTEX PHARMA

  公开号：WO2013109521A1

  公开（公告）日：2013-07-25

  The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及用作离子通道抑制剂的吡喃螺环哌啶酰胺化合物。本发明还提供了包含本发明化合物的药用可接受组合物，以及使用这些组合物治疗各种疾病的方法。
• [EN] DECAHYDROQUINOXALINE DERIVATIVES AND ANALOGS THEREOF<br/>[FR] DÉRIVÉS DE DÉCAHYDROQUINOXALINE ET LEURS ANALOGUES
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2013137479A1

  公开（公告）日：2013-09-19

  A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents -O- or -CH2-; R1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R2 and R3, which are the same or different, each independently represent hydrogen or a lower alkyl group; or R2 and R3 are bonded to form a cyclo-C3-C8 alkyl group; and R4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).

  通用式（1）表示的杂环化合物或其盐：其中m，l和n分别表示1或2的整数；X表示-O-或-CH2-；R1表示氢，较低的烷基基团，羟基较低的烷基基团，保护基或三较低烷氧基较低的烷基基团；R2和R3，相同或不同，各自独立地表示氢或较低的烷基基团；或R2和R3结合形成环-C3-C8烷基基团；R4表示芳香基团或杂环基团，其中芳香基团或杂环基团可能具有一个或多个任意取代基。
• Functionalized Photoreactive Compounds
  申请人：Cherkaoui Mohammed Zoubair

  公开号：US20080274304A1

  公开（公告）日：2008-11-06

  The present invention concerns functionalized photoreactive compounds of formula (I), that are particularly useful in materials for the alignment of liquid crystals. Due to the adjunction of an electron withdrawing group to specific molecular systems bearing an unsaturation directly attached to two unsaturated ring systems, exceptionally high photosensitivities, excellent alignment properties as well as good mechanical robustness could be achieved in materials comprising said functionalized photoreactive compounds of the invention.

  本发明涉及式(I)的官能化光反应化合物，特别适用于液晶对准材料。由于在特定分子系统中的不饱和键直接连接到两个不饱和环系统上附加了一个电子受体基团，因此在包含本发明的这些官能化光反应化合物的材料中可以实现异常高的光敏性、优异的对准性能以及良好的机械稳健性。
• POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF
  申请人：SynDevRx, Inc.

  公开号：US20170258925A1

  公开（公告）日：2017-09-14

  One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

  该发明的一个方面提供了聚合物结合的MetAP2抑制剂。尽管不受任何特定理论的约束，但人们认为通过本文所描述的连接剂将MetAP2抑制核心耦合起来，可以提供比母体小分子更有效的化合物，并具有更优越的药代动力学特性。在该发明的一个方面中，聚合物结合的MetAP2抑制剂可用于治疗疾病的方法，包括向需要治疗的受试者施用治疗有效量的聚合物结合的MetAP2抑制剂。
• HYDROCARBYLIDENE NITROHYDROZINECARBOXIMIDAMIDES AND A METHOD FOR MAKING THE SAME, AS WELL AS THEIR USES AS AN INSECTICIDE
  申请人：Qin ZhaoHai

  公开号：US20110306639A1

  公开（公告）日：2011-12-15

  The present invention discloses hydrocarbylidene nitrohydrozinecarboximidamides and the use thereof as well as a method for making the same. The structural general formula of the compounds are shown in formula I, wherein, R1 is C1-C10 saturated and/or unsaturated aliphatic hydrocarbonyl, benzyl, substituted benzyl, halogenated picolyl, halogenated thiazolyl methyl, tetrahydrofuryl methyl or oxazolyl methyl; R2 is hydrogen, C1-C5 saturated and/or unsaturated aliphatic hydrocarbonyl, phenyl, substituted phenyl, pyridyl or substituted pyridyl; R3 is hydrogen, C1-C10 saturated and/or unsaturated aliphatic hydrocarbonyl, furyl, phenyl, substituted phenyl, benzyl or substituted benzyl. The tests of insecticidal activity show that the hydrocarbylidene nitrohydrozinecarboximidamides shown by formula (I) have high preventive efficiency against insect pests of plants, such as aphid, plant hopper, cotton bollworm, asparagus caterpillar, and the like, and can be used as plant insecticides.

  本发明公开了羟基甲烷基亚硝基羟肼羧酰胺及其用途，以及制备该化合物的方法。所述化合物的结构通式如式I所示，其中，R1为C1-C10饱和和/或不饱和脂肪烃基、苄基、取代苄基、卤代吡啶基、卤代噻唑基甲基、四氢呋喃基甲基或噁唑基甲基；R2为氢、C1-C5饱和和/或不饱和脂肪烃基、苯基、取代苯基、吡啶基或取代吡啶基；R3为氢、C1-C10饱和和/或不饱和脂肪烃基、呋喃基、苯基、取代苯基、苄基或取代苄基。杀虫活性测试显示，式(I)所示的羟基甲烷基亚硝基羟肼羧酰胺对植物害虫（如蚜虫、植食性跳蚤、棉铃虫、天冬毛虫等）具有很高的预防效果，并可用作植物杀虫剂。

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