5-(2-Methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carbaldehyde | 960527-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2-Methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carbaldehyde
• CAS: 960527-39-3
• 化学式: C₁₁H₁₂N₂OS₂
• 分子量: 252.361
• InChiKey: GYHWBLOCKNFDEV-UHFFFAOYSA-N

物化性质

• 沸点：
  411.8±37.0 °C(predicted)
• 密度：
  1.274±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  99.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  甲基碘化镁 、 5-(2-Methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carbaldehyde 以 乙醚 为溶剂， 生成 1-[5-(2-Methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazol-4-yl]ethanol
  参考文献：
  名称：

  THIAZOLE NON-NUCLEOSIDE COMPOUNDS, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND THEIR USE AS ANTIVIRAL AGENTS

  摘要：

  公开号：

  EP2030974B1
• 作为产物：
  描述：

  [5-(2-Methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazol-4-yl]methanol 在 2-碘酰基苯甲酸 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 生成 5-(2-Methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carbaldehyde
  参考文献：
  名称：

  THIAZOLE NON-NUCLEOSIDE COMPOUNDS, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND THEIR USE AS ANTIVIRAL AGENTS

  摘要：

  公开号：

  EP2030974B1

文献信息

• HETEROCYCLIC NON-NUCLEOSIDE COMPOUNDS, THEIR PEPARATION, PHARMACEUTICAL COMPOSITION AND THEIR USE AS ANTIVIRAL AGENTS
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP2030974A1

  公开（公告）日：2009-03-04

  The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on.

  本发明涉及一种抗病毒剂，更具体地，涉及一种具有以下结构的杂环非核苷类化合物，以及它们的制备和包括这些化合物的药物组合物。所述化合物可用作抗病毒剂，以及用于治疗乙型肝炎、流感、疱疹、人类免疫缺陷病毒等疾病的药物。
• THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF
  申请人：Shanghai Theorion Pharmaceutical Co., Ltd.

  公开号：EP2708534B1

  公开（公告）日：2017-07-12
• Heterocyclic Non-Nucleoside Compounds, Their Preparation, Pharmaceutical Composition And Their Use As Antiviral Agents
  申请人：Nan Fajun

  公开号：US20100056569A1

  公开（公告）日：2010-03-04

  The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on.
• Pharmaceutical Use of 2',2-Bis-Thiazole Non-Nucleoside Compounds as Hepatitis C Virus Inhibitor
  申请人：Nan Fajun

  公开号：US20120264793A1

  公开（公告）日：2012-10-18

  The present invention discloses the pharmaceutical use of a 2′,2-bis-thiazole non-nucleoside compound of formula I as an inhibitor of hepatitis C virus (HCV). The 2′,2-bis-thiazole non-nucleoside compound can inhibit the replication of HCV, and thus has an anti-HCV activity and is useful for treating hepatitis C.
• US8653115B2
  申请人：——

  公开号：US8653115B2

  公开（公告）日：2014-02-18