毒理性
◉ 母乳喂养期间使用总结：基于其理化性质和眼内给药途径，预计美替洛尔眼药水不会对哺乳婴儿产生任何不良反应。一些指南指出，凝胶制剂比溶液更受欢迎。为了显著减少使用眼药水后到达母乳中的药物量，可以在眼角按压泪管1分钟或更长时间，然后用吸水纸巾去除多余的溶液。
◉ 对哺乳婴儿的影响：截至修订日期，没有找到关于美替洛尔的相关已发布信息。一项研究调查了哺乳期间服用β受体阻滞剂的母亲，发现服用任何β受体阻滞剂的母亲中不良反应的数量在数值上有所增加，但无统计学意义。虽然对照组的婴儿年龄与受影响的婴儿相匹配，但受影响婴儿的年龄并未说明。没有母亲服用美替洛尔。
◉ 对泌乳和母乳的影响：截至修订日期，没有找到关于正常哺乳期间β受体阻滞或美替洛尔影响的相关已发布信息。一项针对6名高催乳素血症和乳汁过多的患者的研究发现，在使用普萘洛尔进行β肾上腺素能阻滞治疗后，血清催乳素水平没有变化。
◉ Summary of Use during Lactation:Based on its physicochemical properties and its ophthalmic route of administration, metipranolol eye drops would not be expected to cause any adverse effects in breastfed infants. Some guidelines state that gel formulations are preferred over solutions. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
◉ Effects in Breastfed Infants:Relevant published information on metipranolol was not found as of the revision date. A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. None of the mothers were taking metipranolol.
◉ Effects on Lactation and Breastmilk:Relevant published information on the effects of beta-blockade or metipranolol during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.
来源:Drugs and Lactation Database (LactMed)
