β,β-dichloroethylacetate | 53942-53-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: β,β-dichloroethylacetate
• 英文别名: 2,2-dichloroethyl acetate；acetic acid-(2,2-dichloro-ethyl ester)；Essigsaeure-(2,2-dichlor-aethylester)；dichloromethane-methanol-acetic acid；1-Acetoxy-2,2-dichloroethan；1,1-Dichlor-2-acetoxyethan
• CAS: 53942-53-3
• 化学式: C₄H₆Cl₂O₂
• 分子量: 156.996
• InChiKey: DBEYJHSHTGBZIM-UHFFFAOYSA-N

物化性质

• 保留指数：
  899;892;911;919

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  β,β-dichloroethylacetate 以 甲苯 为溶剂， 生成 氯乙烯 、 1,1-二氯乙烯
  参考文献：
  名称：

  Pyrolysis of .beta.-chlorine-containing esters, vinyl ether, and alkene

  摘要：

  DOI：

  10.1021/jo00002a065
• 作为产物：
  描述：

  (diisopropoxyphosphinyl)acetaldehyde 在 氯 作用下， 以 四氯化碳 为溶剂， 生成 β,β-dichloroethylacetate
  参考文献：
  名称：

  Ismailov, V. M.; Moskva, V. V.; Guseinov, F. I., Journal of general chemistry of the USSR, 1986, vol. 56, # 9, p. 1768 - 1771

  摘要：

  DOI：
• 作为试剂：
  描述：

  1-(3-benzoylacryloyl)-L-proline 、 巯基乙酸 以 四氯化碳 、 β,β-dichloroethylacetate 为溶剂， 生成 1-[3-Benzoyl-2-(carboxymethylthio)propionyl]-L-proline
  参考文献：
  名称：

  Substituted thio-substituted benzyl-propionyl-L-prolines

  摘要：

  这份披露描述了新型的取代的ω-芳酰基（丙酰基或丁酰基）-L-脯氨酸及其酯和阳离子盐，它们在哺乳动物中作为降血压剂是有用的。

  公开号：

  US04226775A1

文献信息

• METHOD FOR THE PREPARATION OF 3-FLUOROALKYL-1-METHYLPYRAZOL-4-CARBOXYLIC ACID
  申请人：SOLVAY FLUOR GmbH

  公开号：US20180273486A1

  公开（公告）日：2018-09-27

  The present invention relates to method for the preparation of 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid, wherein it comprises the following steps: step 1, fluoroacetyl fluoride derivative shown in Formula I undergoes condensation with dimethylamino vinyl methyl ketone, as a result, 3-dimethylamino methylene-fluoro-2,4-pentanedione derivative shown in Formula II is formed; step 2, ring closing reaction takes place between said 3-dimethylamino methylene-fluoro-2,4-pentanedione shown in Formula II and methylhydrazine, in this way, 3-fluoroalkyl-1-methyl-4-acetyl pyrazol derivative shown in Formula III is obtained; step 3, the said 3-fluoroalkyl-1-methyl-4-acetyl pyrazol derivative shown in Formula III is oxidized in the presence of alkali, and then acidified, in this way, 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid shown in Formula IV is formed. Preparing method of present invention, wherein the required preparing route is simple, the raw material cost is low, the resulting yield of each step is high, and it is suitable for industrialization.

  本发明涉及一种制备3-氟烷基-1-甲基吡唑-4-羧酸的方法，其中包括以下步骤：步骤1，式I所示的氟乙酰氟衍生物与二甲基氨基乙烯基甲基酮发生缩合反应，从而形成式II所示的3-二甲基氨基亚甲基-氟-2,4-戊二酮衍生物；步骤2，式II所示的3-二甲基氨基亚甲基-氟-2,4-戊二酮与甲基肼发生环合反应，得到式III所示的3-氟烷基-1-甲基-4-乙酰吡唑衍生物；步骤3，式III所示的3-氟烷基-1-甲基-4-乙酰吡唑衍生物在碱的存在下被氧化，然后酸化，从而形成式IV所示的3-氟烷基-1-甲基吡唑-4-羧酸。本发明的制备方法，所需制备路线简单，原料成本低，每个步骤的产率高，适合工业化生产。
• Derivatives of α-phosphorylated aldehydes
  作者：Valeh Mehralioǧlu Ismailov、Adnan Aydin、Fizuddin Guseynov

  DOI：10.1016/s0040-4020(99)00429-9

  日期：1999.7

  add thiols, amides and ethyleneimine to give stable hemi-thioacetals, hemiamidals and hemiaminal. From the silyl ether of hemiisopropyl thioacetal above 140°C, an α-ketophosphonate is obtained by the elimination of silane followed by the rearrangement of the oxirane intermediate. Alkylations of α-phosphorylated aldehydes with alkyl bromides gave enol ethers. However, dihalogenoalkanes such as 1,2-dibromoethane

  描述了用于α-磷酸化醛的选择性氯化的条件，作为合成α-单氯和α，α-二氯取代的衍生物的手段。二氯衍生物显示出高反应活性，并容易添加硫醇，酰胺和亚乙基亚胺，从而获得稳定的半硫缩醛，半缩醛和半缩醛。从140℃以上的半异丙基硫缩醛的甲硅烷基醚中，通过除去硅烷，然后重新排列环氧乙烷中间体，得到α-酮膦酸酯。α-磷酸化醛与烷基溴的烷基化得到烯醇醚。然而，二卤代烷烃，例如1，2-二溴乙烷或1，3-二溴丙烷与烯醇醚一起产生磷酸环戊烷，它们都是反式构型。
• Olefin block copolymers processes for producing the same and uses thereof
  申请人：——

  公开号：US20030055179A1

  公开（公告）日：2003-03-20

  The present invention provides polymers having any one of properties including affinity for metals or polar resins, impact resistance, mar resistance, heat resistance, rigidity, oil resistance, transparency, anti-fogging properties, electric insulating properties, high breakdown voltage, coating properties, low-temperature flexibility, moldability, environmental degradation, fluidity and dispersibility, and provides a process for preparation thereof. The olefin block copolymers (A-1) of the invention are represented by the formula (I) PO 1 —g 1 —B 1 (I) (wherein PO 1 is a segment composed of repeating units derived from an olefin having 2 to 20 carbon atoms, g 1 is an ester, ether, amide, imide, urethane, urea, silylether or carbonyl linkage, and B 1 is a segment containing an unsaturated hydrocarbon or a hetero atom). The olefin block copolymers are suitable for uses in adhesives; various molded articles such as construction and civil engineering materials, automobile interior and exterior materials, gasoline tanks, electric and electronic parts, medical care and sanitation materials, materials of miscellaneous goods, resin materials having environmental degradation properties, films and sheets; modifiers and dispersions.

  本发明提供了具有以下任一性质的聚合物，包括对金属或极性树脂的亲和性，抗冲击性，抗刮伤性，耐热性，刚度，耐油性，透明性，防雾性能，电绝缘性能，高击穿电压，涂料性能，低温柔性，可塑性，环境降解性，流动性和分散性，并提供其制备方法。本发明的烯烃嵌段共聚物（A-1）由公式（I）表示：PO1-g1-B1（I）（其中PO1是由具有2至20个碳原子的烯烃衍生的重复单元组成的片段，g1是酯，醚，酰胺，亚胺，脲，硅醚或羰基连接，B1是含有不饱和碳氢化合物或杂原子的片段）。烯烃嵌段共聚物适用于粘合剂；各种成型品，如建筑和土木工程材料，汽车内外饰料，汽油箱，电子和电气零件，医疗保健和卫生材料，杂货物料，具有环境降解性能的树脂材料，薄膜和片材；改性剂和分散剂。
• DOCETAXEL PROCESS AND POLYMORPHS
  申请人：Palle Raghavendracharyulu Venkata

  公开号：US20100197944A1

  公开（公告）日：2010-08-05

  Processes for preparing substantially pure docetaxel, new crystalline forms of docetaxel and processes for preparation thereof, processes for preparing docetaxel trihydrate, and pharmaceutical compositions comprising docetaxel.

  制备基本纯度紫杉醇的过程，紫杉醇的新晶体形式及其制备过程，制备紫杉醇三水合物的过程，以及包含紫杉醇的制药组合物的过程。
• Phosphonamidate compounds
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0071544A1

  公开（公告）日：1983-02-09

  New phosphonamidate substituted imino or amino acid compounds, and pharmaceutically acceptable salts thereof, as described herein, possess angiotensin converting enzyme activity and are thus useful as anti-hypertensive agents.

  本文所述的新型膦酰胺取代的亚氨基或氨基酸化合物及其药学上可接受的盐类具有血管紧张素转换酶活性，因此可用作抗高血压药物。