6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride | 783349-62-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride
• 英文别名: 6-chloro-2,3,4,9-tetrahydro-1H-β-carboline hydrochloride；6-chloro-1,2,3,4-tetrahydro-β-carboline hydrochloride；6-Chloro-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride；6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;hydrochloride
• CAS: 783349-62-2
• 化学式: C₁₁H₁₁ClN₂*ClH
• 分子量: 243.136
• InChiKey: BZINTWDYEPHEOE-UHFFFAOYSA-N

物化性质

• 溶解度：
  32.4 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.89
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  27.8
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  β-丙内酯 、 6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以29%的产率得到3-(6-chloro-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propanoic acid
  参考文献：
  名称：

  WO2020037155A5

  摘要：

  公开号：

  WO2020037155A5
• 作为产物：
  描述：

  6-chloro-2,3,4,9-tetrahydro-1H-β-carboline-1-carboxylic acid 在 盐酸 作用下， 以 水 为溶剂， 反应 1.0h， 以82%的产率得到6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride
  参考文献：
  名称：

  WO2020037155A5

  摘要：

  公开号：

  WO2020037155A5

文献信息

• Beta-carbolines useful for treating inflammatory disease
  申请人：Hepperle E. Michael

  公开号：US20050239781A1

  公开（公告）日：2005-10-27

  This invention provides beta-carboline compounds of formula III-A-aa: wherein Q, G, R 1 , R 2 , R 3 , and R 6b are as described in the specification. The compounds are useful for treating diseases such as inflammatory diseases and cancer.

  这项发明提供了III-A-aa式的β-咔啉化合物： 其中Q、G、R1、R2、R3和R6b如规范中所述。这些化合物可用于治疗炎症性疾病和癌症等疾病。
• [EN] BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE<br/>[FR] BETA-CARBOLINES UTILES POUR TRAITER UNE MALADIE INFLAMMATOIRE
  申请人：MILLENNIUM PHARM INC

  公开号：WO2004092167A1

  公开（公告）日：2004-10-28

  This invention provides beta-carboline compounds of formula (I) wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2 mediated diseases such as inflammatory diseases and cancer.

  这项发明提供了式（I）中的β-咔啉化合物，其中环A是取代的吡啶基、嘧啶基、吗啉基、哌啶基、哌嗪基、吡咯啉基、吡喃基、四氢呋喃基、环己基、环戊基或硫代吗啉基环，R1、R2和R3如规范中所述。这些化合物是IKK-2抑制剂，可用于治疗IKK-2介导的疾病，如炎症性疾病和癌症。
• METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO-$g(b)-CARBOLINE DERIVATIVES
  申请人：NEUREX CORPORATION

  公开号：EP0520987A1

  公开（公告）日：1993-01-07
• EP0520987A4
  申请人：——

  公开号：EP0520987A4

  公开（公告）日：1992-05-13
• 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF
  申请人：Recreo Pharmaceuticals LLC

  公开号：US20210163479A1

  公开（公告）日：2021-06-03

  The present invention provides 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole derivative compounds and uses thereof. In particular, compounds of the invention are of the formula: where n is an integer from 0-4; each of z, a1, a2, a3, a4, and a5 is independently 0 or 1, provided at least one of a1-a5 is 1; Ar 1 is phenyl or a nitrogen atom containing 6-membered heteroaryl; Cyc 1 is 5, 6, or 7-membered nitrogen atom containing heterocyclyl optionally containing one to three additional substituents in addition to R 2a and R 2b ; X 1 is —C(═O)—, —C(═O)—NR 6 —, or —SO 2 —NH—; each of R 1a and R 1c is independently C 1 -C 6 alkylene; R 1b is optionally substituted C 1 -C 6 alkylene; X 2 is O or NR 6 ; each R 1 is independently halogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, —OR a , or NR b R c , where R a hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or a hydroxyl protecting group, and wherein each of R b and R c is independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, or a nitrogen protecting group; each of R 2a and R 2b is independently hydrogen, halogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, —OR a , or —NR b R c , where R a hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or a hydroxyl protecting group, and wherein each of R b and R c is independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, or a nitrogen protecting group, or R 2a and R 2b together with the carbon atom to which they are attached to form a cycloalkyl group; and Q is an optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted C 3 -C 8 cycloalkyl.