1,4-dipropanoylpiperazine-2,5-dione | 34850-62-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4-dipropanoylpiperazine-2,5-dione
• 英文别名: 1,4-dipropionyl-piperazine-2,5-dione；1,4-Dipropionyl-piperazin-2,5-dion；1,4-Di(propanoyl)piperazine-2,5-dione
• CAS: 34850-62-9
• 化学式: C₁₀H₁₄N₂O₄
• 分子量: 226.232
• InChiKey: GJBQPJPEBXKJSF-UHFFFAOYSA-N

物化性质

• 沸点：
  434.6±38.0 °C(Predicted)
• 密度：
  1.277±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-dipropanoylpiperazine-2,5-dione 、 丁炔二酸二乙酯 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以59%的产率得到diethyl 6-hydroxy-2-oxo-1-propanoyl-3-(propanoylamino)-2,7-dihydro-1H-azepine-4,5-dicarboxylate
  参考文献：
  名称：

  One-Pot Synthesis of Polysubstituted 3-Amino-2-oxo-2,7-dihydro-1H-azepines

  摘要：

  A facile and efficient synthesis of novel seven-membered heterocyclic derivatives containing 3-aminoazepan-2-one backbone is described using 1,4-protected piperazine-2,5-diones and alkynes as starting materials. The reaction may undergo Michael addition, unusual nucleophilic attack to an amide group, and keto-enol tautomerization. The reaction showed different reactivity when using substrates with different protecting groups: it had higher efficiency when using either alkanoyl-protecting group with cesium carbonate as the base, or benzoyl-protecting group with triethylamine as the base, but no reaction when using benzyl or allyl protecting groups with a variety of bases (Et3N, DBU, K2CO3, Cs2CO3, KHCO3, CsHCO3, and KOt-Bu).

  DOI：

  10.1055/s-0033-1340473
• 作为产物：
  描述：

  甘氨酸酐 、 丙酸酐 以87%的产率得到1,4-dipropanoylpiperazine-2,5-dione
  参考文献：
  名称：

  One-Pot Synthesis of Polysubstituted 3-Amino-2-oxo-2,7-dihydro-1H-azepines

  摘要：

  A facile and efficient synthesis of novel seven-membered heterocyclic derivatives containing 3-aminoazepan-2-one backbone is described using 1,4-protected piperazine-2,5-diones and alkynes as starting materials. The reaction may undergo Michael addition, unusual nucleophilic attack to an amide group, and keto-enol tautomerization. The reaction showed different reactivity when using substrates with different protecting groups: it had higher efficiency when using either alkanoyl-protecting group with cesium carbonate as the base, or benzoyl-protecting group with triethylamine as the base, but no reaction when using benzyl or allyl protecting groups with a variety of bases (Et3N, DBU, K2CO3, Cs2CO3, KHCO3, CsHCO3, and KOt-Bu).

  DOI：

  10.1055/s-0033-1340473

文献信息

• Detergent composition and method for producing it
  申请人：UNILEVER PLC

  公开号：EP0030089A1

  公开（公告）日：1981-06-10

  A particulate alkaline detergent composition is disclosed which is suitable for washing fabrics and exhibiting good detergency, stability and bleaching while the level of inorganic material deposited on the fabrics is at an acceptably low level. The composition comprises a synthetic detergent active, a mixture of tri-polyphosphate and orthophosphate in the ratio of 20:1 to 3:1 and a mixture of a peroxygen bleach such as perborate and a bleach activator such as tet- raacetylethylenediamine. The phosphates constitute from 10 to 40% of the composition while the bleach system constitutes from 5 to 30%. The amount of pyrophosphate, if any, should be kept below 5% Soap may be added to the composition. The compositions may be prepared by mixing the bleach system and optionally the alkali metal phosphate with a spray dried powder containing the remaining constituents.

  本发明公开了一种微粒碱性洗涤剂组合物，该组合物适用于洗涤织物，具有良好的去污力、稳定性和漂白性，同时织物上沉积的无机物含量低得可以接受。该组合物包括一种合成洗涤剂活性物、一种比例为 20:1 至 3:1 的三聚磷酸酯和正磷酸酯的混合物，以及一种过氧漂白剂（如过硼酸盐）和一种漂白活化剂（如四乙酰乙二胺）的混合物。磷酸盐占组合物的 10%至 40%，而漂白体系占 5%至 30%。焦磷酸盐的用量（如果有的话）应保持在 5%以下，可在组合物中添加肥皂。可将漂白剂和碱金属磷酸盐与含有其余成分的喷雾干燥粉末混合，制备组合物。
• Detergent compositions
  申请人：UNILEVER PLC

  公开号：EP0056723A1

  公开（公告）日：1982-07-28

  A particulate alkaline detergent with unexpectantly good bleaching performance and with reduced phosphorus content contains 5-40% detergent active, 12.5-25% tripolyphosphate, 7.0-36% aluminosilicate builder such as zeolite, 5-30% peroxybleach such as sodium perborate and 0.1 to 15% activator such as TAED, the perborate to TAED ratio being between 2:1 and 15:1. The detergent active may be anionic material or a mixture of an anionic material and a minor amount of nonionic material. The compositions are particularly suitable for containing fluorescers and show surprisingly improved bleaching performance as water hardness increases.

  一种漂白性能出乎意料地好并能降低磷含量的微粒碱性洗涤剂含有 5-40%的洗涤活性剂、12.5-25%的三聚磷酸钠、7.0-36%的铝硅酸盐掺合物（如沸石）、5-30%的过氧漂白剂（如过硼酸钠）和 0.1-15%的活化剂（如 TAED），过硼酸钠和 TAED 的比例在 2:1 和 15:1 之间。活性洗涤剂可以是阴离子材料，也可以是阴离子材料和少量非离子材料的混合物。这种组合物特别适合含有荧光剂，而且随着水硬度的增加，漂白性能也会惊人地提高。
• Detergent additives and detergent compositions containing them
  申请人：UNILEVER PLC

  公开号：EP0070190A1

  公开（公告）日：1983-01-19

  A builder system for detergent compositions comprises 25 to 97% by weight of an aluminosilicate cation-exchange material such as Zeolite A and 3 to 75% by weight, in total, of an organic precipitant builder having a polyvalent anion, for example, an alkyl or alkenyl malonate or succinate, and an organic sequestrant such as a nitrilotriacetate. The ratio of precipitant to sequestrant is 10:1 to 1:10. The builder mix is advantageously used in detergent compositions containing less than 10% inorganic phosphate, and gives good results in zero-phosphate compositions.

  一种用于洗涤剂组合物的增效剂体系包括 25-97%（重量）的硅酸铝阳离子交换材料（如沸石 A）和 3-75%（重量）的具有多价阴离子的有机沉淀剂增效剂（如烷基或烯基丙二酸酯或琥珀酸酯）以及有机螯合剂（如氮基三乙酸酯）。沉淀剂和螯合剂的比例为 10:1 至 1:10。这种增效剂混合物适用于无机磷酸盐含量低于 10%的洗涤剂组合物，在零磷酸盐组合物中也有很好的效果。
• Bleach activator granules
  申请人：UNILEVER N.V.

  公开号：EP0053859A1

  公开（公告）日：1982-06-16

  Effervescent bleach activator granules for use in washing and/or bleaching compositions comprising a bleach activator, a peroxoborate and a binding material are disclosed. Preferred granules include an alkali metal perborate monohydrate, preferably in a proportion at least equal to the amount of the bleach activator. These granules have the advantage that the reduction of mechanical loss when used in washing machines combined with a fast dissolution of and reaction between the bleach activator and the percompound in close proximity at a high local pH should improve the bleach performance, particularly in the low/medium temperature range, to a substantial degree.

  本发明公开了用于洗涤和/或漂白组合物的泡腾漂白活化剂颗粒，该组合物由漂白活化剂、过硼酸盐和结合材料组成。优选的颗粒包括碱金属过硼酸盐一水合物，其比例最好至少等于漂白活化剂的量。这些颗粒的优点是，在洗衣机中使用时可减少机械损耗，同时漂白活化剂和过化合物在较高的局部 pH 值下快速溶解并发生反应，从而在很大程度上改善漂白性能，特别是在中低温范围内。
• Cleaning composition
  申请人：UNILEVER N.V.

  公开号：EP0070079A2

  公开（公告）日：1983-01-19

  A low phosphate, alumino-silicate built cleaning composition having improved bleach performance is described comprising a) 15-50% by weight of a water-insoluble alumino-silicate cation exchange material; b) 3-30% by weight of a peroxide bleach; c) 0.5-15% by weight of an activator for said peroxide bleach; and d) 1-15% by weight of a nitrilotriacetic acid compound, wherein the percentage quantities of (a) + 2(d) is between 30 and 55.

  描述了一种低磷酸盐、铝硅酸盐结构的清洁组合物，它具有更好的漂白性能，包括 a) 15-50% （重量百分比）的水不溶性铝硅酸盐阳离子交换材料； b) 3-30% （重量百分比）的过氧化物漂白剂； c) 0.5-15%（重量百分比）的过氧化物漂白剂活化剂；以及 d) 1-15%(重量)的硝基三乙酸化合物，其中(a)+2(d)的数量百分比在 30 至 55 之间。