(2-硝基苯甲酰基)重氮甲烷 | 4203-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2-硝基苯甲酰基)重氮甲烷
• 英文名称: 2-Nitro-benzoyldiazomethan
• 英文别名: 2-Diazo-1-(2-nitrophenyl)ethanone；2-diazo-1-(2-nitrophenyl)ethanone
• CAS: 4203-26-3
• 化学式: C₈H₅N₃O₃
• 分子量: 191.146
• InChiKey: VOSSLASNONSHOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2927000090

反应信息

• 作为反应物：
  描述：

  (2-硝基苯甲酰基)重氮甲烷 在 盐酸 、 ammonium sulfide 、 乙醇 、 溶剂黄146 作用下， 生成 1H,1H'-2,2'-Biindolylidene-3,3'-dione
  参考文献：
  名称：

  Arndt; Eistert; Partale, Chemische Berichte, 1927, vol. 60, p. 1369

  摘要：

  DOI：
• 作为产物：
  描述：

  邻硝基苯甲酸 在 氯化亚砜 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 (2-硝基苯甲酰基)重氮甲烷
  参考文献：
  名称：

  Photochemistry of 2-(methoxycarbonyl)phenyl azide studied by matrix-isolation spectroscopy. A new slippery energy surface for phenylnitrene

  摘要：

  Broad-band irradiation (lambda > 350 nm) of 2-(methoxycarbonyl)phenyl azide (1) in Ar at 10 K monitored by IR and UV-vis spectroscopy resulted in the formation of at least rive major products, all of which were shown to be photointerconvertible under these conditions. The two products showing intact methoxycarbonyl carbonyl stretching absorption bands were assigned as (2-(methoxycarbonyl)phenyl)nitrene (2) and 3-(methoxycarbonyl)-1,2,4,6-azacycloheptatetraene (3), probably formed as a result of ring expansion of 2, while the products showing sharp absorption bands at 2118 and 2088 cm-1 due to ketene functional groups were assigned to the geometrical mixture of carbonyl oximino benzenes 16, presumably formed by formal 1,4-methoxy migration in 2, and the one showing carbonyl absorption at 1857 cm-1 was assigned as N-methoxyazetinone 15, produced as a result of photocyclization of 16. These assignments were unequivocally verified by generating the same reaction mixtures by photodecarbonylation of N-methoxyisatin (23) in an argon matrix at 10 K. That phenylnitrene-pyridylmethylene interconversions were not attained once the 2-methoxycarbonyl group was introduced was also shown.

  DOI：

  10.1021/ja00072a015

文献信息

• [EN] HETEROARYLAMINO-PHENYLKETONE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS<br/>[FR] DERIVES D'HETEROARYLAMINO-PHENYLCETONE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE KINASES
  申请人：IMCLONE SYSTEMS INC

  公开号：WO2005000813A1

  公开（公告）日：2005-01-06

  The present invention relates to compounds that inhibit VEGF receptor tyrosine kinases, especially KDR, pharmaceutical compositions that contain such compounds, methods of treating VEGF receptor kinase-dependent diseases and conditions in mammals using such compounds and composition and methods for their manufacture.

  本发明涉及抑制VEGF受体酪氨酸激酶，特别是KDR的化合物，包含这种化合物的药物组合物，使用这种化合物和组合物治疗哺乳动物中依赖VEGF受体激酶的疾病和病况的方法，以及其制造方法。
• Aktivierte Thiocarbonsäure-ester; 8¹. Herstellung von 2-Oxodithiocarbonsäure-estern aus Diazoketonen
  作者：Andrzej Sawluk、Jürgen Voss

  DOI：10.1055/s-1986-31843

  日期：——

  Activated Thiocarboxylic Esters; 8. Preparation of 2-Oxidithiocarboxylic Esters from Diazoketones Reaction of diazoketones, which are easily available from acid chlorides, with elemental sulfur in the presence of triethylamine, followed by alkylation yields alkyl 2-oxodithiocarboxylates.

  活化硫代羧酸酯； 8. 从重氮酮制备 2-氧代二硫代羧酸酯 在三乙胺存在下，重氮酮（很容易从酸性氯化物中获得）与元素硫发生反应，然后进行烷基化，生成 2-氧代二硫代羧酸烷基酯。
• Arndt; Eistert, Chemische Berichte, 1935, vol. 68, p. 200,204
  作者：Arndt、Eistert

  DOI：——

  日期：——
• Arndt; Eistert; Amende, Chemische Berichte, 1928, vol. 61, p. 1949
  作者：Arndt、Eistert、Amende

  DOI：——

  日期：——
• Regitz,M., Chemische Berichte, 1966, vol. 99, p. 3128 - 3147
  作者：Regitz,M.

  DOI：——

  日期：——