吡哆醛腙

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 吡哆醛腙
• 英文名称: pyridoxal hydrazide
• 英文别名: 5-(Hydroxymethyl)-4-methanehydrazonoyl-2-methylpyridin-3-ol；5-(hydroxymethyl)-4-methanehydrazonoyl-2-methylpyridin-3-ol
• 化学式: C₈H₁₁N₃O₂
• 分子量: 181.194
• InChiKey: ZFVPNTKHPMVRFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.7
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吡哆醛 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以80%的产率得到吡哆醛腙
  参考文献：
  名称：

  A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging

  摘要：

  A pyridoxal-based chemosensor was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were investigated in a methanol: HEPES solution. The compound displayed selectivity for Cu2+, as evidenced by a colorless to yellow color change, which was characterized using UV-vis spectroscopy. The fluorescence of the compound can be quenched only by Cu2+, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging. (C) 2014 Fang-Jun Huo. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2014.06.017

文献信息

• Enhanced chemical sensing for Cu²⁺ based on composites of ZIF-8 with small molecules
  作者：Jun Zhang、Xiuyang Zhao、Xuefeng Liu、Chuan Dong

  DOI：10.1039/c9ra10695b

  日期：——

  Two organic molecules, pyridoxal hydrazide (PAH) and salicylaldehyde based Rhodamine B hydrazone (RBS) were integrated into zeolitic imidazolate framework-8 (ZIF-8) to give composites, namely PAH/ZIF-8 and RBS/ZIF-8. The organic molecules and ZIF-8 are proposed to be assembled via hydrogen bonds and π–π stacking in the composites. The mass fraction of PAH and RBS in the composites was calculated to

  将吡哆醛酰肼 (PAH) 和水杨醛基罗丹明 B 腙 (RBS) 两种有机分子整合到沸石咪唑酸酯骨架 8 (ZIF-8) 中得到复合材料，即 PAH/ZIF-8 和 RBS/ZIF-8。有机分子和 ZIF-8 被提议通过复合材料中的氢键和 π-π 堆叠组装。复合材料中 PAH 和 RBS 的质量分数计算为 21.86% 和 29.3%。PAH/ZIF-8的荧光被Cu 2+规律地猝灭。计算得出，PAH/ZIF-8 的 Cu 2+检测限为1.42 nM，比 PAH 低一个数量级。Cu 2+的检出限对于 RBS/ZIF-8，确定为 0.8 μM，比 RBS 低三倍。这两种复合材料都显示出对Cu 2+的高选择性，而不是竞争金属离子。PAH/ZIF-8荧光传感器成功应用于环境水中Cu 2+的测定。PAH/ZIF-8 在细胞成像中表现出优异的细胞膜通透性和低细胞毒性。增强型化学传感器是通过将小分子引入 ZIF-8
• A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging
  作者：Cai-Xia Yin、Li-Jun Qu、Fang-Jun Huo

  DOI：10.1016/j.cclet.2014.06.017

  日期：2014.9

  A pyridoxal-based chemosensor was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were investigated in a methanol: HEPES solution. The compound displayed selectivity for Cu2+, as evidenced by a colorless to yellow color change, which was characterized using UV-vis spectroscopy. The fluorescence of the compound can be quenched only by Cu2+, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging. (C) 2014 Fang-Jun Huo. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.