6-(2-iodo-acetylamino)-hexanoic acid | 2018-22-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(2-iodo-acetylamino)-hexanoic acid
• 英文别名: 6-[(2-iodoacetyl)amino]hexanoic acid
• CAS: 2018-22-6
• 化学式: C₈H₁₄INO₃
• 分子量: 299.109
• InChiKey: BSJPRRFEIBHGRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  465.5±30.0 °C(Predicted)
• 密度：
  1.661±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 6-(2-iodo-acetylamino)-hexanoic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以67%的产率得到琥珀酰亚胺基-6-[(碘乙酰基)氨基]己酸酯
  参考文献：
  名称：

  WO2006/82184

  摘要：

  公开号：
• 作为产物：
  描述：

  碘代乙酸酐 、 6-氨基己酸 以 1,4-二氧六环 为溶剂， 反应 19.0h， 以100%的产率得到6-(2-iodo-acetylamino)-hexanoic acid
  参考文献：
  名称：

  WO2006/82184

  摘要：

  公开号：

文献信息

• [EN] GLYCAN CONJUGATES AND USE THEREOF<br/>[FR] CONJUGUÉS DE GLYCANE ET LEUR UTILISATION
  申请人：ACADEMIA SINICA

  公开号：WO2014210564A1

  公开（公告）日：2014-12-31

  Described herein are synthetic glycan conjugates comprising a carrier and a glycan moiety derived from Neisseria meningitidis, wherein the glycan moiety is covalently linked to the carrier through a linker. Also provided herein are a mixture of the glycan conjugates thereof, immmunogenic compositions thereof, and kits thereof. The invention further provides methods of using the synthetic glycan conjugates and immunogenic compositions thereof to treat and/or reduce the risk of infectious diseases such as bacterial infections.

  本文描述了一种合成糖基结合物，包括载体和源自脑膜炎奈瑟菌的糖基部分，其中糖基部分通过连接剂与载体共价结合。本文还提供了这些糖基结合物的混合物，其免疫原性组成物和工具包。该发明还提供了使用合成糖基结合物和其免疫原性组成物来治疗和/或减少细菌感染等传染病风险的方法。
• [EN] NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS D'ACIDE NUCLÉIQUE-POLYPEPTIDE ET UTILISATIONS DE CELLES-CI
  申请人：AVIDITY BIOSCIENCES LLC

  公开号：WO2019071028A1

  公开（公告）日：2019-04-11

  Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

  本文披露了包含与修饰的多核苷酸分子和聚合物结合基团的组合物和药物配方。本文还描述了利用包含与多核苷酸分子和聚合物结合基团共轭的组合物或药物配方治疗癌症的方法。
• RM2 ANTIGENS AND USE THEREOF
  申请人：WONG Chi-Huey

  公开号：US20160193310A1

  公开（公告）日：2016-07-07

  Described herein are synthetic glycan conjugates, immmunogenic compositions thereof, vaccines thereof, and kits thereof. The present invention further provides methods of using the synthetic glycan conjugates, immunogenic compositions, or vaccines thereof to treat and/or prevent and/or diagnose proliferative diseases such as cancer. The provided glycan conjugate comprises a carrier and a glycan moiety of Formula (I-i) or Formula (I-ii): (structurally represented).

  本文描述了合成糖基结合物、其免疫原性组合物、疫苗以及相关的工具包。本发明还提供了使用合成糖基结合物、免疫原性组合物或其疫苗来治疗和/或预防和/或诊断增殖性疾病如癌症的方法。所提供的糖基结合物包括载体和式(I-i)或式(I-ii)的糖基部分：（结构表示）。
• Oxime conjugates and methods for their formation and use
  申请人：Papisov I Mikhail

  公开号：US20060058513A1

  公开（公告）日：2006-03-16

  The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for creating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a reducing agent to form the biodegradable biocompatible polyketal. The resultant biodegradable biocompatible polyketals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating animals includes the administration of the biodegradable biocompatible polyketal in which biologically active compounds or diagnostic labels can be disposed. The present invention also relates to chiral polyketals, methods for their preparation, and methods for use in chromatographic applications, specifically in chiral separations. A method for forming the chiral polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a suitable reagent to form the chiral polyketal. A method for use in chiral separations includes the incorporation of the chiral polyketals in the mobile phase during a chromatographic separation, or into chiral stationary phases such as gels. The present invention further relates to chiral polyketals as a source for chiral compounds, and methods for generating such chiral compounds.

  本发明涉及可生物降解、生物相容的聚酮醚，其制备方法以及通过给予可生物降解、生物相容的聚酮醚来创建动物的方法。在一个方面，制备可生物降解、生物相容的聚酮醚的方法包括将一种乙二醇特异性氧化剂与多糖结合以形成醛中间体，该中间体与还原剂结合以形成可生物降解、生物相容的聚酮醚。所得到的可生物降解、生物相容的聚酮醚可以进行化学修饰以纳入额外的亲水基团。治疗动物的方法包括给予可生物降解、生物相容的聚酮醚，其中可以分布生物活性化合物或诊断标记。本发明还涉及手性聚酮醚，其制备方法以及在色谱应用中使用的方法，特别是在手性分离中使用。制备手性聚酮醚的方法包括将一种乙二醇特异性氧化剂与多糖结合以形成醛中间体，该中间体与适当的试剂结合以形成手性聚酮醚。在手性分离中使用的方法包括将手性聚酮醚纳入色谱分离的流动相中，或纳入手性固定相中，例如凝胶中。本发明还涉及手性聚酮醚作为手性化合物的来源，以及生成这种手性化合物的方法。
• Amplified luminescent homogeneous immunoassay
  申请人：——

  公开号：US20040175696A1

  公开（公告）日：2004-09-09

  Methods are disclosed for determining minute quantities of an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte, if present, causes a substrate having an oxidant cleavable linker and a photosenstizer to come into close proximity. The photosenstizer generates singlet oxygen which oxidatively cleaves the linker to form a product which can be detected in a sandwich detection assay such as LOCI. The amount of product detected is related to the amount of analyte in the medium. Compositions, kits, and compounds are also disclosed.

  本发明公开了一种用于确定疑似含有分析物的介质中微量分析物的方法。其中一种方法包括在条件下处理疑似含有分析物的介质，使得如果分析物存在，则会使得具有氧化剂可分解连接剂和光敏剂的底物进入接近状态。光敏剂产生单线态氧，氧化性地裂解连接剂形成可在夹心检测测定（如LOCI）中检测到的产物。检测到的产物量与介质中分析物的量有关。本发明还公开了组合物、试剂盒和化合物。