6-nonanoylaminohexanoic acid | 69242-00-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-nonanoylaminohexanoic acid
• 英文别名: 6-[(1-oxynonyl)amino]hexanoic acid；n-nonanoylamidohexanoic acid；Hexanoic acid, 6-[(1-oxononyl)amino]-；6-(nonanoylamino)hexanoic acid
• CAS: 69242-00-8
• 化学式: C₁₅H₂₉NO₃
• mdl: MFCD12544229
• 分子量: 271.4
• InChiKey: SBLCUTIOHNPTHL-UHFFFAOYSA-N

物化性质

• 沸点：
  468.5±28.0 °C(Predicted)
• 密度：
  0.980±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.866
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-nonanoylaminohexanoic acid 在 氯化亚砜 作用下， 生成 n-nonanoylamidohexanoyl chloride
  参考文献：
  名称：

  US6307076

  摘要：

  公开号：
• 作为产物：
  描述：

  壬酸 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成 6-nonanoylaminohexanoic acid
  参考文献：
  名称：

  Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa

  摘要：

  It is urgent to develop novel anti-Pseudomonas agents that should also be active against multidrug resistant P. aeruginosa. Expanding the antibacterial spectrum of muraymycins toward P. aeruginosa was investigated by the systematic structure activity relationship study. It was revealed that two functional groups, a lipophilic side chain and a guanidino group, at the accessory moiety of muraymycins were important for the anti-Pseudomonas activity, and analogue 29 exhibited antibacterial activity against a range of P. aeruginosa strains with the minimum inhibitory concentration values of 4-8 mu g/mL.

  DOI：

  10.1021/ml5000096

文献信息

• Site-specific effect of polar functional group-modification in lipids of TLR2 ligands for modulating the ligand immunostimulatory activity
  作者：Yohei Arai、Shinsuke Inuki、Yukari Fujimoto

  DOI：10.1016/j.bmcl.2018.03.042

  日期：2018.5

  of TLR2, small polar regions were found in the hydrophobic TLR2 pocket. Interactions between the polar residues and ligands were explored here by designing and synthesizing a Pam2CSK4 derivative of the TLR2 ligands, containing an amide group within the lipid moiety. We evaluated the binding affinities and immunomodulatory activities of these ligands. Results suggested that the amide groups in the lipid

  Toll样受体2（TLR2）是TLR先天性免疫受体家族的成员，它能够识别细菌中的脂蛋白并通过诱导各种细胞因子的表达来调节免疫反应。TLR2有一个大的疏水口袋，可识别TLR2配体上的长脂肪酰基。然而，很少有研究集中在疏水性TLR2袋的性质上。基于TLR2的X射线晶体结构，在疏水性TLR2的口袋中发现了小的极性区域。通过设计和合成Pam 2 CSK 4，探索了极性残基与配体之间的相互作用。TLR2配体的衍生物，在脂质部分包含一个酰胺基。我们评估了这些配体的结合亲和力和免疫调节活性。结果表明脂质链中的酰胺基团与TLR2疏水脂质结合口袋中的极性残基相互作用。
• Process for preparing and/or purifying amido acid phenyl ester sulfonates
  申请人：Procter & Gamble Company

  公开号：US06369250B1

  公开（公告）日：2002-04-09

  The present invention relates to a process for the preparation of a purified salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. The process comprises the steps of: (a) providing a source of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate; (b) admixing the source with a water-based purification system to form a purification mixture, the water-based purification system having water present at a ratio of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate to water ranging from about 1:0.05 to about 1:50, preferably from about 1:0.1 to about 1:40; (c) separating a purified salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate from the purification mixture; and (d) collecting said purified salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. In preferred embodiments, the purification mixture includes a processin aide such as ethyl alcohol, propyl alcohol, isopropyl alcohol, acetone and mixtures thereof.

  本发明涉及一种制备4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐的纯化过程。该过程包括以下步骤：(a)提供4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐的来源；(b)将该来源与基于水的纯化系统混合，形成纯化混合物，其中基于水的纯化系统中水的比例为4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐与水的比例范围大约为1:0.05至1:50，优选范围为1:0.1至1:40；(c)从纯化混合物中分离出4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐；(d)收集所述的纯化4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐。在优选实施方式中，纯化混合物包括处理助剂，如乙醇、丙醇、异丙醇、丙酮和它们的混合物。
• Compositions and methods for using zwitterionic polymeric suds enhancers
  申请人：Sivik Robert Mark

  公开号：US20050124738A1

  公开（公告）日：2005-06-09

  The present invention relates to methods for using zwitterionic polymeric suds enhancers (stabilizers) to increase the suds and/or foam volume and suds and/or foam retention in suds-forming and/or foam-forming compositions comprising such zwitterionic polymeric suds stabilizers. Suitable suds-forming and/or foam-forming compositions comprise one or more zwitterionic polymeric suds stabilizers.

  本发明涉及使用带电离性高分子泡沫增强剂（稳定剂）的方法，以增加含有这种带电离性高分子泡沫稳定剂的泡沫和/或泡沫体积以及泡沫和/或泡沫在泡沫形成和/或泡沫形成组合物中的保持能力。适合用作泡沫形成和/或泡沫形成组合物的是含有一个或多个带电离性高分子泡沫稳定剂的组合物。
• Compositions and methods for using polymeric suds enhancers
  申请人：Sivik Robert Mark

  公开号：US20050026803A1

  公开（公告）日：2005-02-03

  The present invention relates to methods for using polymeric suds enhancers (stabilizers) to increase the suds and/or foam volume and suds and/or foam retention in suds-forming and/or foam-forming compositions comprising such polymeric suds stabilizers. Suitable suds-forming and/or foam-forming compositions comprise one or more polymeric suds stabilizers. The polymeric suds stabilizers suitable for use in the methods and/or compositions of the present invention comprise cationic, anionic, and noncharged monomer units, or units having mixtures thereof, wherein said polymers have an average cationic charge density from about 0.05 to about 5 units per 100 daltons molecular weight at a pH of from about 4 to about 12.

  本发明涉及使用聚合物泡沫增强剂（稳定剂）的方法，以增加包含此类聚合物泡沫稳定剂的泡沫和/或泡沫体积和泡沫和/或泡沫保持时间的泡沫形成和/或泡沫形成组合物中的泡沫。适合用于泡沫形成和/或泡沫形成组合物的包括一个或多个聚合物泡沫稳定剂。适用于本发明方法和/或组合物的聚合物泡沫稳定剂包括阳离子、阴离子和非带电单体单元或其中混合物，其中所述聚合物在pH为4至12时的平均阳离子电荷密度为每100道尔顿分子量约0.05至约5个单位。
• COMPOSITIONS AND METHODS FOR USING POLYMERIC SUDS ENHANCERS
  申请人：SIVIK Robert Mark

  公开号：US20070244027A1

  公开（公告）日：2007-10-18

  The present invention relates to methods for using polymeric suds enhancers (stabilizers) to increase the suds and/or foam volume and suds and/or foam retention in suds-forming and/or foam-forming compositions comprising such polymeric suds stabilizers. Suitable suds-forming and/or foam-forming compositions comprise one or more polymeric suds stabilizers. The polymeric suds stabilizers suitable for use in the methods and/or compositions of the present invention comprise cationic, anionic, and noncharged monomer units, or units having mixtures thereof, wherein said polymers have an average cationic charge density from about 0.05 to about 5 units per 100 daltons molecular weight at a pH of from about 4 to about 12.

  本发明涉及使用聚合物泡沫增强剂（稳定剂）的方法，以增加含有此类聚合物泡沫稳定剂的泡沫和/或泡沫体积以及泡沫和/或泡沫在泡沫形成和/或泡沫形成组合物中的保持能力。适用于泡沫形成和/或泡沫形成组合物的合适的泡沫稳定剂包括一个或多个聚合物泡沫稳定剂。适用于本发明方法和/或组合物的聚合物泡沫稳定剂包括阳离子、阴离子和非带电单体单元或具有其混合物的单元，其中所述聚合物在pH为4到12之间，具有平均阳离子电荷密度从约0.05到约5个单位/100道尔顿分子量。