2-hydroxy-6-naphthalenecarbonyl chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-hydroxy-6-naphthalenecarbonyl chloride
• 英文别名: 2-hydroxy-6-naphthoic acid chloride；6-hydroxy-2-naphthoylchloride；6-Hydroxy-2-naphthoyl chloride；6-hydroxynaphthalene-2-carbonyl chloride
• 化学式: C₁₁H₇ClO₂
• 分子量: 206.628
• InChiKey: UTFQLMARJGZTHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-6-naphthalenecarbonyl chloride 在 ammonium hydroxide 、 三氟乙酸酐 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 32.5h， 生成 6-氰基-2-萘酚
  参考文献：
  名称：

  3-Aryl-1,2,4-oxadiazole Derivatives Active Against Human Rhinovirus

  摘要：

  The human rhinovirus (hRV) is the causative agent of the common cold that often aggravates respiratory complications in patients with asthma or chronic obstructive pulmonary disease. The high rate of mutations and variety of serotypes are limiting the development of anti-hRV drugs, which emphasizes the need for the discovery of novel lead compounds. Previously, we identified antiviral compound 1 that we used here as the starting material for developing a novel compound series with high efficacy against hRV-A and -B. Improved metabolic stability was achieved by substituting an ester moiety with a 1,2,4-oxadiazole group. Specifically, compound 3k exhibited a high efficacy against hRV-B14, hRV-A21, and hRV-A71, with EC50 values of 66.0, 22.0, and 3.7 nM, respectively, and a relevant hepatic stability (59.6 and 40.7% compound remaining after 30 min in rat and human liver microsomes, respectively). An in vivo study demonstrated that 3k possessed a desirable pharmacokinetic profile with low systemic clearance (0.158 L.h(-1).Kg(-1)) and modest oral bioavailability (27.8%). Hence, 3k appears to be an interesting candidate for the development of antiviral lead compounds.

  DOI：

  10.1021/acsmedchemlett.8b00134
• 作为产物：
  描述：

  2-羟基-6-萘甲酸 在 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 2-hydroxy-6-naphthalenecarbonyl chloride
  参考文献：
  名称：

  由不对称1,3,4-硫代二唑衍生的新金属成因剂：合成，单晶结构，同构和光学性质

  摘要：

  报道了衍生自具有介晶性质的不对称1,3,4-噻二唑2的一系列铜（II）配合物1。所有前体2和3均表现出近晶A相和/或近晶C相，而铜络合物形成向列相，SmA或SmC相。衍生物2和3形成的中间相可能归因于酰胺（-NH）和酚（-OH）基团在分子内或分子间诱导的H键。介晶的2-（5-（2-（己氧基氧基）萘-6-基）-1,3,4-恶二唑-2-基）苯酚的晶体和分子结构（2 ; n = 6，m＝ 6）通过X射线结构分析确定。它在单斜空间群P -1中结晶，a = 7.4255（18）Å，b = 8.209（2）Å，c = 17.315（5）Å，Z = 2。观察到N2和H1A原子之间的分子间H键（d = 1.89Å）的夹角为161.5°。所有分子堆积成倾斜层排列，并观察到π-π相互作用（约3.56Å）。可变温度FTIR和1 H NMR光谱也用于探测化合物2（m = 0，n = 6）中可能形成的H键。这些化合

  DOI：

  10.1016/j.tet.2007.09.031

文献信息

• COATING COMPOSITIONS SUITABLE FOR USE WITH AN OVERCOATED PHOTORESIST
  申请人：Amara John P.

  公开号：US20110003250A1

  公开（公告）日：2011-01-06

  In one aspect, organic coating compositions, particularly antireflective coating compositions, are provided that comprise that comprise a diene/dienophile reaction product. In another aspect, organic coating compositions, particularly antireflective coating compositions, are provided that comprise a component comprising a hydroxyl-naphthoic group, such as a 6-hydroxy-2-naphthoic group Preferred compositions of the invention are useful to reduce reflection of exposing radiation from a substrate back into an overcoated photoresist layer and/or function as a planarizing, conformal or via-fill layer.

  在一个方面，提供了有机涂层组合物，特别是抗反射涂层组合物，其包括二烯/二烯亲双反应产物。在另一个方面，提供了有机涂层组合物，特别是抗反射涂层组合物，其包括一个含有羟基-萘甲基团的组分，例如6-羟基-2-萘甲基团。本发明的优选组合物可用于减少曝光辐射从基板反射回覆盖的光刻胶层，并/或作为平坦化、整平或填孔层。
• 흑색 아조-금속 착물, 이를 포함하는 감광성 수지 조성물 및 이를 이용하여 제조된 경화막
  申请人：SAMYANG CORPORATION 주식회사 삼양사(120110515934) Corp. No ▼ 110111-4720945BRN ▼101-86-66838

  公开号：KR20180058545A

  公开（公告）日：2018-06-01

  본 발명은 흑색 아조-금속 착물, 이를 포함하는 감광성 수지 조성물 및 이를 이용하여 제조된 컬러필터에 관한 것으로서, 본 발명의 흑색 아조-금속착물은 열안정성, 내화학성 및 용해도가 우수하여 이를 포함하는 감광성 수지 조성물 및 이용한 컬러필터는 색유지율, 광학밀도 및 면 저항 등의 광학특성이 우수하다.

  本发明涉及黑色偶氮-金属络合物，包括含有该物质的感光树脂组合物，以及由此制造的彩色滤光片，本发明的黑色偶氮-金属络合物具有优良的热稳定性、耐化学性和溶解性，含有该物质的感光树脂组合物和制造的彩色滤光片具有优异的色彩保持率、光学密度和表面抗性等光学特性。
• New metallomesogens derived from unsymmetric 1,3,4-thiodiazoles: synthesis, single crystal structure, mesomorphism, and optical properties
  作者：Cheng-Tsung Liao、Yueh-Ju Wang、Chi-Shuen Huang、Hwo-Shuenn Sheu、Gene-Hsiang Lee、Chung K. Lai

  DOI：10.1016/j.tet.2007.09.031

  日期：2007.12

  A series of copper(II) complexes 1 derived from unsymmetric 1,3,4-thiadiazoles 2 exhibiting mesogenic properties are reported. All the precursors 2 and 3 exhibited smectic A or/and smectic C phases, whereas, copper complexes formed nematic, SmA or SmC phases. The mesophases formed by derivatives 2 and 3 were probably attributed to the H-bondings induced both intramolecularly or/and intermolecularly

  报道了衍生自具有介晶性质的不对称1,3,4-噻二唑2的一系列铜（II）配合物1。所有前体2和3均表现出近晶A相和/或近晶C相，而铜络合物形成向列相，SmA或SmC相。衍生物2和3形成的中间相可能归因于酰胺（-NH）和酚（-OH）基团在分子内或分子间诱导的H键。介晶的2-（5-（2-（己氧基氧基）萘-6-基）-1,3,4-恶二唑-2-基）苯酚的晶体和分子结构（2 ; n = 6，m＝ 6）通过X射线结构分析确定。它在单斜空间群P -1中结晶，a = 7.4255（18）Å，b = 8.209（2）Å，c = 17.315（5）Å，Z = 2。观察到N2和H1A原子之间的分子间H键（d = 1.89Å）的夹角为161.5°。所有分子堆积成倾斜层排列，并观察到π-π相互作用（约3.56Å）。可变温度FTIR和1 H NMR光谱也用于探测化合物2（m = 0，n = 6）中可能形成的H键。这些化合
• Method for producing naphthalene carboxylic acid amide compound
  申请人：Wakamori Hiroyuki

  公开号：US20080045720A1

  公开（公告）日：2008-02-21

  The present invention provides a method for producing a naphthalenecarboxylic acid amide compound represented by formula [1] comprising, reacting a naphthalenecarboxylic acid halide compound represented by formula [2] with ammonium acetate in a solvent having an ether bond. According to the method of the present invention, a naphthalene carboxylic acid amide compound can be obtained at high yield and at low cost.

  本发明提供了一种制备萘甲酸酰胺化合物（由式[1]表示）的方法，包括将由式[2]表示的萘甲酸卤化物与醋酸铵在具有醚键的溶剂中反应。根据本发明的方法，可以以高收率和低成本获得萘甲酸酰胺化合物。
• Polyester resin exhibiting anisotropy in molten state and composition thereof
  申请人：POLYPLASTICS CO. LTD.

  公开号：EP0334619A2

  公开（公告）日：1989-09-27

  A liquid crystal polymer having a good balance between high processability and heat resistance is provided by a polyester resin exhibiting anisotropy in the molten state which comprises constituent units represented by the formulae (I) to (III) as indispensible components in amounts of 35 to 90% by mole, 0.5 to 30% by mole and 0.5 to 30% by mole respectively:

  一种在高加工性和耐热性之间取得良好平衡的液晶聚合物是由一种在熔融状态下表现出各向异性的聚酯树脂提供的，该聚酯树脂由式 (I) 至 (III) 所代表的组成单元作为不可或缺的成分，其含量分别为 35% 至 90%（按摩尔计）、0.5% 至 30%（按摩尔计）和 0.5%至 30%（按摩尔计）：