N,N'-dimethylhexamethylene-1,6-diacrylamide | 76245-67-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-dimethylhexamethylene-1,6-diacrylamide
• 英文别名: 2-Propenamide, N,N'-1,6-hexanediylbis[N-methyl-；N-methyl-N-[6-[methyl(prop-2-enoyl)amino]hexyl]prop-2-enamide
• CAS: 76245-67-5
• 化学式: C₁₄H₂₄N₂O₂
• 分子量: 252.357
• InChiKey: TVQIXFFCPKIFOJ-UHFFFAOYSA-N

物化性质

• 沸点：
  450.6±28.0 °C(Predicted)
• 密度：
  0.975±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-dimethylhexamethylene-1,6-diacrylamide 、 1,2,3,4-四氢罂粟碱 在 溶剂黄146 作用下， 反应 4.0h， 生成 N,N'-4,11-dimethyl-4,11-diaza-3,12-dioxotetramethylene-1,14-diyl-bis-(RS)-tetrahydropapaverine
  参考文献：
  名称：

  Neuromuscular blocking agents. Some approaches to short acting compounds

  摘要：

  A series of amidic and N-methylamidic methyl and trideuteromethyl quaternary analogues of atracurium have been prepared. All were less potent and longer acting neuromuscular blocking agents than atracurium, and all showed appreciable vagal blockade at neuromuscular blocking doses. Replacement of NCH3 by NCD3 failed to affect potency. Fluorosubstitution in the central chain did not reduce duration of action. Attachment of acyloxy substituents to the interquaternary chain of atracurium and related compounds adjacent to their ester groups shortened the duration of action significantly. Diformyloxy substitution was the most effective in reducing duration without adversely affecting other properties apart from potency, which was significantly less than that of atracurium.

  DOI：

  10.1016/0223-5234(92)90180-9
• 作为产物：
  描述：

  N,N'-二甲基-1,6-己二胺 、 丙烯酰氯 在 三乙胺 、 邻苯三酚 作用下， 以 苯 为溶剂， 反应 0.5h， 以69%的产率得到N,N'-dimethylhexamethylene-1,6-diacrylamide
  参考文献：
  名称：

  Neuromuscular blocking agents. Some approaches to short acting compounds

  摘要：

  A series of amidic and N-methylamidic methyl and trideuteromethyl quaternary analogues of atracurium have been prepared. All were less potent and longer acting neuromuscular blocking agents than atracurium, and all showed appreciable vagal blockade at neuromuscular blocking doses. Replacement of NCH3 by NCD3 failed to affect potency. Fluorosubstitution in the central chain did not reduce duration of action. Attachment of acyloxy substituents to the interquaternary chain of atracurium and related compounds adjacent to their ester groups shortened the duration of action significantly. Diformyloxy substitution was the most effective in reducing duration without adversely affecting other properties apart from potency, which was significantly less than that of atracurium.

  DOI：

  10.1016/0223-5234(92)90180-9

文献信息

• SILICONE ACRYLAMIDE COPOLYMER
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20150274854A1

  公开（公告）日：2015-10-01

  The present invention relates to a silicone acrylamide copolymer of high acrylamide monomer content which has transparency and low modulus, employing the following configuration. The copolymer is suitably used for various kinds of medical devices, particularly ophthalmic lenses such as a contact lens, an intraocular lens, an artificial cornea, and is especially suitable for a contact lens. A copolymer comprising (A) a multi-functional (meth)acrylamide monomer having at least one siloxane bond and at least two (meth)acrylamide groups within a molecule and (B) a mono-functional linear silicone (meth)acrylamide monomer.

  本发明涉及一种高丙烯酰胺单体含量的硅丙烯酰胺共聚物，具有透明度和低模量，采用以下配置。该共聚物适用于各种医疗器械，特别是眼科镜片，如隐形眼镜，人工晶状体，人工角膜，尤其适用于隐形眼镜。共聚物包括（A）至少具有一个硅氧烷键和至少两个（甲基）丙烯酰胺基团的多功能（甲基）丙烯酰胺单体和（B）单功能线性硅（甲基）丙烯酰胺单体。
• Polar group-containing olefin copolymer, process for preparing the same, thermoplastic resin composition contaning the copolymer, and uses thereof
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1186619A2

  公开（公告）日：2002-03-13

  The present invention is intended to provide a polar group-containing olefin copolymer having excellent adhesion properties to metals or polar resins and excellent compatibility therewith, a process for preparing the copolymer, a thermoplastic resin composition containing the copolymer, and uses thereof. The polar group-containing olefin copolymer comprises a constituent unit derived from an α-olefin of 2 to 20 carbon atoms, and a constituent unit derived from a straight-chain, branched or cyclic polar group-containing monomer having at the end a polar group such as a hydroxyl group or an epoxy group and/or a constituent unit derived from a macromonomer having at the end a polymer segment obtained by anionic polymerization, ring-opening polymerization or polycondensation. The polar group-containing olefin copolymer can be prepared by polymerizing the α-olefin with the polar group-containing monomer and/or the macromonomer in the presence of a metallocene catalyst. The polar group-containing olefin copolymer and the thermoplastic resin composition containing the copolymer are used for films, sheets, modifiers, building/civil engineering materials, automobile exterior trim, electric/electronic parts, coating bases, compatibilizing agents, etc.

  本发明旨在提供一种对金属或极性树脂具有极佳粘附性和相容性的含极性基团的烯烃共聚物、制备该共聚物的工艺、含有该共聚物的热塑性树脂组合物及其用途。含极性基团的烯烃共聚物包括一个由 2 至 20 个碳原子的 α-烯烃衍生的组成单元和一个由直链、支链或环状含极性基团单体衍生的组成单元，直链、支链或环状含极性基团单体的末端具有极性基团，如羟基或环氧基，和/或一个由大单体衍生的组成单元，大单体的末端具有通过阴离子聚合、开环聚合或缩聚反应获得的聚合物段。含极性基团的烯烃共聚物可通过在茂金属催化剂存在下使α-烯烃与含极性基团的单体和/或大单体聚合来制备。含极性基团的烯烃共聚物和含有该共聚物的热塑性树脂组合物可用于薄膜、板材、改性剂、建筑/土木工程材料、汽车外饰、电气/电子零件、涂层基料、相容剂等。
• PROCESS FOR THE PRODUCTION OF LIVING (CO)POLYMERS AND USE OF THE (CO)POLYMERS
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1266910A1

  公开（公告）日：2002-12-18

  The purpose of the present invention is to provide polymerization catalyst which can produce quite efficiently (co)polymer having number average molecular weight and number of molecules which are accurately controlled in producing method of (co)polymer by the polymerization of polar unsaturated compound, and provide living polymerized (co)polymer obtained according to the producing method. For the purpose, polymerization catalyst composition which comprises the composition comprising organic oxysalt compound and hydroxycarbonyl compound having at least both an alcoholic hydroxyl group and a carbonyl group in the same molecule is provided and the polar unsaturated compound is polymerized by using the polymerization catalyst composition. The composition containing the obtained (co)polymer were able to provide thermosetting powder coating composition having particularly excellent characteristics.

  本发明的目的是提供一种聚合催化剂，该催化剂可在通过极性不饱和化合物聚合生产 （共）聚合物的方法中相当有效地生产具有精确控制的平均分子量数和分子数的（共）聚合 物，并提供根据该生产方法获得的活聚合（共）聚合物。为此，提供了聚合催化剂组合物，该组合物由有机草酸盐化合物和羟基羰基化合物组成，羟基羰基化合物在同一分子中至少具有醇羟基和羰基，使用该聚合催化剂组合物对极性不饱和化合物进行聚合。含有所获得的（共）聚合物的组合物能够提供具有特别优异特性的热固性粉末涂料组合物。
• Dentalmaterialien auf der Basis von Hydroxyalkylacrylamiden
  申请人：Ivoclar Vivadent AG

  公开号：EP1374828A1

  公开（公告）日：2004-01-02

  Polymerisierbare Zusammensetzungen, die mindestens ein Hydroxyalkylacrylamid mit der Formel (I) enthalten in der Xfür einen C1- bis C12-Alkylenrest oder C7- bis C15-Alkylenphenylenrest steht, R1für einen C1- bis C10-Alkylrest, Phenyl oder Wasserstoff steht, m,nunabhängig voneinander 0, 1 oder 2 sind, wobei m + n = 2, und R2für Wasserstoff, Methyl oder X'-OH steht, wenn m ≥ 1, oder X'-OH steht, wenn m = 0, wobei X' eine der für X angegebenen Bedeutungen hat, und wobei für n = 2 die beiden Reste R1 und für m = 2 die beiden Reste -X- gleich oder verschieden sein können und die sich insbesondere als Dentalmaterialien eignen.

  含有至少一种式 (I) 的羟烷基丙烯酰胺的可聚合组合物 其中 X 代表 C1 至 C12 烯基或 C7 至 C15 烯基、 R1 代表 C1 至 C10 烷基、苯基或氢、 m、n 分别为 0、1 或 2，其中 m + n = 2，以及 R2 代表氢、甲基或 X'-OH（如果 m ≥ 1），或 X'-OH（如果 m = 0），其中 X'具有为 X 规定的含义之一，以及 其中 n = 2 时，两个基 R1 和 m = 2 时，两个基 -X- 可以相同或不同，特别适合用作牙科材料。
• Hydrolysestabiles selbstätzendes Einkomponentendentaladhäsiv
  申请人：Ivoclar Vivadent AG

  公开号：EP1674067A1

  公开（公告）日：2006-06-28

  Dentale Zusammensetzung enthaltend (i) mindestens ein saures (Meth)acrylamidmonomer, das zwei oder mehr polymerisierbare Gruppen aufweist, (ii) mindestens ein saures Monomer, das nur eine polymerisierbare Gruppe aufweist, und (iii) mindestens einen Polymerisationsinitiator.

  一种牙科组合物，包含 (i) 至少一种具有两个或两个以上可聚合基团的酸性（甲基）丙烯酰胺单体，(ii) 至少一种仅具有一个可聚合基团的酸性单体，以及 (iii) 至少一种聚合引发剂。