3-hydroxypropyl tetradecanoate | 59540-18-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-hydroxypropyl tetradecanoate
• 英文别名: 3-hydoxypropyl tetradecanoate；1-Myristoyl-1,3-propandiol
• CAS: 59540-18-0
• 化学式: C₁₇H₃₄O₃
• 分子量: 286.455
• InChiKey: WAQSLLZSQDBVSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxypropyl tetradecanoate 在 四氮唑 、 叔丁基过氧化氢 、 三氟乙酸 作用下， 以 四氢呋喃 、 癸烷 、 二氯甲烷 为溶剂， 反应 5.5h， 生成
  参考文献：
  名称：

  Structure–Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10, and GPR174

  摘要：

  Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening of orphan G-protein-coupled receptors (GPCRs) identified two LysoPS specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family. Herein, we examined the structure-attivity relationships of a series of synthetic LysoPS analogues toward these recently deorphanized LysoPS,receptors, based on the idea that LysoPS can be regarded as consisting of distinct modules (fatty acid, glycerol, and L-Serine) connected by phosphodiester and ester linkages. Starting from the endogenous ligand (1-oleoyl-LysolPS, 1), we optimized the structure of each module and the ester linkage. Accordingly, we identified some structural requirements of each module for potency and for receptor subtype selectivity. Further assembly of individually structure-optimized modules yielded a series of potent and LysoPS receptor subtype-selective agonists, particularly for P2Y10 and GPR174.

  DOI：

  10.1021/jm5020082
• 作为产物：
  描述：

  2-Tridecyl-1,3-dioxane 在 四乙基溴化铵 、 水 、 2-碘酰基苯甲酸 作用下， 反应 1.0h， 以79%的产率得到3-hydroxypropyl tetradecanoate
  参考文献：
  名称：

  2-碘氧基苯甲酸/溴化四乙铵/水：乙醛的氧化裂解的有效组合

  摘要：

  已经开发出一种简单有效的方法，用于将环状和非环状缩醛分别氧化为相应的羟烷基羧酸酯和简单酯。在四乙基溴化铵存在下，将2-碘氧基苯甲酸（IBX）用于水性介质中的反应。该方案的显着特征包括反应时间短，对环境无害的试剂和溶剂以及中等至高产率。 邻碘氧苯甲酸-缩醛-氧化-羟烷基酯-醇

  DOI：

  10.1055/s-0028-1087986

文献信息

• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Anti-fouling Paints and Coatings
  申请人：Reactive Surfaces LTD

  公开号：US20150191607A1

  公开（公告）日：2015-07-09

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peptide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文披露了聚合材料，例如涂层、塑料、层压材料、复合材料、弹性体、粘合剂或密封剂；表面处理，例如纺织品整理或蜡；填充剂，用于这种聚合材料或表面处理，包括酯酶（例如脂肪水解酶、硫酸酯水解酶、有机磷化合物降解酶）的酶，降解细胞壁和/或细胞膜成分的酶（例如溶菌酶、裂解转葡糖苷酶），生物杀菌或生物稳定肽，和/或肽酶。本文还披露了通过将酶并入能够通过脂肪水解酶、水解酶和/或脲酶的活性进行化学交联的材料中，改变材料性能（例如使用寿命、柔韧性或刚度）的方法。
• Eibl,H.; Westphal,O., Justus Liebigs Annalen der Chemie, 1970, vol. 738, p. 170 - 173
  作者：Eibl,H.、Westphal,O.

  DOI：——

  日期：——
• Facile oxidative hydrolysis of acetals to esters using hypervalent iodine(III)/LiBr combination in water
  作者：Waraporn Panchan、Supanimit Chiampanichayakul、Deanna L. Snyder、Siriporn Yodbuntung、Manat Pohmakotr、Vichai Reutrakul、Thaworn Jaipetch、Chutima Kuhakarn

  DOI：10.1016/j.tet.2010.01.098

  日期：2010.4

  The combination of (diacetoxy)iodobenzene (Phl(OAc)(2), DIB) and lithium bromide (LiBr) efficiently oxidized cyclic and acyclic acetals to the corresponding hydroxyalkyl carboxylic esters and simple esters in good to excellent yields The merits of this reaction are that it employs commercially available and non-explosive hypervalent iodine(III) reagent, water as the solvent, a short reaction tune, and mild reaction conditions (C) 2010 Elsevier Ltd All rights reserved
• OZONOLYSIS REACTIONS IN LIQUID CO2 AND CO2-EXPANDED SOLVENTS
  申请人：University Of Kansas

  公开号：EP2209547A2

  公开（公告）日：2010-07-28