N-(4-chlorophenyl)octadecanamide | 89735-31-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorophenyl)octadecanamide
• 英文别名: N-(4-chlorophenyl) stearamide；stearic acid-(4-chloro-anilide)；Stearinsaeure-(4-chlor-anilid)；Stearinsaeure-p-chloranilid；p-Chlor-octadecanilid
• CAS: 89735-31-9
• 化学式: C₂₄H₄₀ClNO
• 分子量: 394.041
• InChiKey: JAGHTVVPRGFHHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  27
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-苯十八醯胺 在 次氯酸叔丁酯 、 溴 作用下， 以 二氯甲烷 为溶剂， 生成 N-(4-chlorophenyl)octadecanamide
  参考文献：
  名称：

  28.光化学转化。第十六部分。内酯的新型合成

  摘要：

  DOI：

  10.1039/jr9650000181

文献信息

• Nano-Magnetic Sulfonic Acid Catalyzed Facile Synthesis of Diverse Amide Derivatives
  作者：Subramaniapillai Ganesan、Jagatheeswaran Kothandapani、Asaithampi Ganesan

  DOI：10.1055/s-0036-1588319

  日期：——

  excellent surface catalytic potential of Fe3O4–OSO3H is utilized in the synthesis of symmetrically and unsymmetrically substituted urea derivatives via transamidation reactions. The scope of the surface catalysis is further extended in transamidation reactions of cyclic and acyclic amide derivatives, and in the amidation of fatty acids. In both transamidation and amidation reactions, the catalyst is reusable

  摘要 Fe 3 O 4 -OSO 3 H的优异的表面催化潜力可用于通过氨基转移反应合成对称和不对称取代的脲衍生物。在环和无环酰胺衍生物的氨基转移反应以及脂肪酸的酰胺化反应中，表面催化的范围进一步扩大。在氨基转移和酰胺化反应中，该催化剂可重复使用多达五次，而活性没有明显损失。 Fe 3 O 4 -OSO 3 H的优异的表面催化潜力可用于通过氨基转移反应合成对称和不对称取代的脲衍生物。在环和无环酰胺衍生物的氨基转移反应以及脂肪酸的酰胺化反应中，表面催化的范围进一步扩大。在氨基转移和酰胺化反应中，该催化剂可重复使用多达五次，而活性没有明显损失。
• ZnO nanofluid as a structure base catalyst for chemoselective amidation of aliphatic carboxylic acids
  作者：Fatemeh Tamaddon、Fatemeh Aboee、Alireza Nasiri

  DOI：10.1016/j.catcom.2011.09.023

  日期：2011.11

  ZnO nanofluids were synthesized and utilized as a new reaction media in the preparation of amides via direct amidation of aliphatic carboxylic acids with primary amines under solvent-free conditions. High yields and good selectivity are achieved with this psudo-homogeneous catalyst, while the recovered nanoZnO was reusable.

  合成了ZnO纳米流体，并通过无溶剂条件下脂族羧酸与伯胺的直接酰胺化反应，将其用作制备酰胺的新反应介质。用这种假均相催化剂可实现高收率和良好的选择性，而回收的纳米ZnO可重复使用。
• Synthesis of amides directly from carboxylic acids and hydrazines
  作者：Nivedita Bhardwaj、Nancy Tripathi、Sanjay Kumar、Shreyans K. Jain

  DOI：10.1039/d3ob01268a

  日期：——

  method for amide bond synthesis described here utilizes carboxylic acids and hydrazines in the presence of a catalytic amount of ZnCl2. This is the first report that highlights the use of hydrazine as an amine partner for amide synthesis directly with carboxylic acids. Ammonia (gas) is the only by-product in this method. The methodology is simple and could help in the synthesis of peptides and natural

  这里描述的酰胺键合成方法在催化量的ZnCl 2存在下利用羧酸和肼。这是第一份强调使用肼作为胺伴侣直接与羧酸合成酰胺的报告。氨（气体）是该方法中唯一的副产品。该方法简单，有助于肽和天然产物衍生物的合成。
• Nano Sulfated Titania as Solid Acid Catalyst in Direct Synthesis of Fatty Acid Amides
  作者：Mona Hosseini-Sarvari、Esmat Sodagar、Mohammad Mahdi Doroodmand

  DOI：10.1021/jo2002769

  日期：2011.4.15

  Nanosized sulfated titania was prepared by a sol gel hydrothermal process. X-ray diffraction (XRD), transmission electron, and scanning electron micrographs (TEM and SEM), FT-IR specific surface area, and BET N(2) adsorption were employed to characterize the properties of the synthesized sulfated TiO(2). The results indicate that both anatase and rutile TiO(2) are obtainable. This prepared sulfated titania showed high catalytic activity in direct amidation of fatty acids as well as benzoic acids with various amines under solvent-free conditions.
• National Socialism and Literary Adaptation: Gustaf Gründgens’s Der Schritt vom Wege and Helmut Käutner’s Kleider Machen Leute
  作者：Paul Coates

  DOI：10.1111/1468-0483.00162

  日期：2000.4

  Eric Rentschler argues that ‘film production in the Third Reich offers a strikingly concrete example’ of the theoretical construct of ‘the dominant cinema’ (‘Hollywood’) devised by film theorists. But is the era of ‘Germany’s Hollywood’ ideological in the same way as Hollywood, or in a different way? Consideration of National Socialist adaptations of non‐Nazi texts may help one determine the specific meaning of the ideological in the Nazi context. The admittedly small area of National Socialist literary adaptation acquires a disproportionately revelatory potential due to the clearly perceptible disparities between the original, pre‐Nazi texts and their Nazi‐era reworkings. The adaptations considered here are Gustaf Gründgens’s Der Schritt vom Wege (1939), based on Fontane’s Effi Briest – a parti‐cularly problematic work for National Socialist ideology – and Helmut Käutner’s version of Gottfried Keller’s Kleider machen Leute (1940), whose admission of its own approximate relationship with the original narrative seems to dismiss the probably irresoluble problem of fidelity to the original, but which is also problematic.