ethylene glycol monophenyl ether phosphate | 18168-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ethylene glycol monophenyl ether phosphate
• 英文别名: 2-phenoxyethanol dihydrogen phosphate；2-phenoxyethanol hydrogen phosphate；phenoxyethanol dihydrogenphosphate；phosphoric acid phenoxyethyl ester；Phenoxyethanol hydrogen phosphate；phenoxyethylene glycol phosphate；2-phenoxyethanol phosphate；phenoxyethanol phosphate；Ethanol, 2-phenoxy-, phosphate；2-phenoxyethyl dihydrogen phosphate
• CAS: 18168-30-4
• 化学式: C₈H₁₁O₅P
• 分子量: 218.146
• InChiKey: KSTDNMVCVQWPJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氯化胆碱 、 ethylene glycol monophenyl ether phosphate 在 吡啶 、 三异丙基氯硅烷 、 水 、 异丙醇 作用下， 反应 3.0h， 以0.055 g的产率得到2-Phenoxyethyl 2-(trimethylazaniumyl)ethyl phosphate
  参考文献：
  名称：

  Antileishmanial Ring-Substituted Ether Phospholipids

  摘要：

  Three series of ring-substituted ether phospholipids were synthesized carrying N,N,N-trimethylammonium, N-methylpiperidino, or N-methylmorpholino headgroups. The first series is substituted by 2-cyclohexyloxyethyl or 2-(4-alkylidenecyclohexyloxy)ethyl groups, the second series by cyclohexylidenealkyl or adamantylidenealkyl moieties, and the third series by 2-aryloxyethyl or 6-aryloxyhexyl groups in the alkyl portion of the molecule. The antileishmanial activity of the new compounds was evaluated in vitro against the promastigote forms of L. donovani and L. infantum using an MTT (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide)-based microassay as a marker of cell viability. Analogues 12, 15, 24, 30, 32, 41, 43, and 45 were more potent than the control compound miltefosine (hexadecylphosphocholine) against both L. donovani and L. infantum while, derivatives 13 and 42 were equipotent to miltefosine. Analogues 16, 17, 19, 20 were more potent than miltefosine against L. infantum and compounds 27, 31, 44 were more active than miltefosine against L. donovani. Differential scanning calorimetry (DSC) was used to probe the role of individual ether phospholipids on the physicochemical properties of model membranes. The DSC scans showed that the active compounds have a more profound effect on the thermotropic properties of model membrane bilayers than the less active ones.

  DOI：

  10.1021/jm020972c
• 作为产物：
  描述：

  己二酸,聚合2,2-二甲基-1,3-丙二醇和2,5-呋喃二酮,苯酸酯 在 三乙胺 、 三氯氧磷 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 ethylene glycol monophenyl ether phosphate
  参考文献：
  名称：

  Antileishmanial Ring-Substituted Ether Phospholipids

  摘要：

  Three series of ring-substituted ether phospholipids were synthesized carrying N,N,N-trimethylammonium, N-methylpiperidino, or N-methylmorpholino headgroups. The first series is substituted by 2-cyclohexyloxyethyl or 2-(4-alkylidenecyclohexyloxy)ethyl groups, the second series by cyclohexylidenealkyl or adamantylidenealkyl moieties, and the third series by 2-aryloxyethyl or 6-aryloxyhexyl groups in the alkyl portion of the molecule. The antileishmanial activity of the new compounds was evaluated in vitro against the promastigote forms of L. donovani and L. infantum using an MTT (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide)-based microassay as a marker of cell viability. Analogues 12, 15, 24, 30, 32, 41, 43, and 45 were more potent than the control compound miltefosine (hexadecylphosphocholine) against both L. donovani and L. infantum while, derivatives 13 and 42 were equipotent to miltefosine. Analogues 16, 17, 19, 20 were more potent than miltefosine against L. infantum and compounds 27, 31, 44 were more active than miltefosine against L. donovani. Differential scanning calorimetry (DSC) was used to probe the role of individual ether phospholipids on the physicochemical properties of model membranes. The DSC scans showed that the active compounds have a more profound effect on the thermotropic properties of model membrane bilayers than the less active ones.

  DOI：

  10.1021/jm020972c

文献信息

• Polycondensation Product Base on Aromatic or Heteroaromatic Compounds, Method for the Production Thereof, and Use Thereof
  申请人：Wieland Philipp

  公开号：US20080108732A1

  公开（公告）日：2008-05-08

  Disclosed is a polycondensation product comprising A) an aromatic or heteroaromatic compound containing 5 to 10 C atoms or heteroatoms, said compound being provided with an average of 1 to 300 oxyethylene groups and/or oxypropylene groups per molecule which are linked to the aromatic or heteroaromatic compound via an O atom or N atom, and optionally B) an aromatic compound selected among the group comprising phenols, phenol ether, naphthols, naphthol ether, anilines, furfuryl alcohols, and/or an aminoplast former selected among the group comprising melamine (derivatives), urea (derivatives), and carboxylic acid amides, and C) an aldehyde selected among the group comprising formaldehyde, glyoxylic acid, and benzaldehyde or mixtures thereof, the benzaldehyde optionally containing acid groups in the form of COOM a , SO 3 M a , and PO 3 M a , wherein M=H, akali metal or alkaline earth metal, ammonium, or organic amine radicals and a=½, 1, or 2. Surprisingly, the inventive polycondensation product causes very good liquefaction of hydraulic binding agents, e.g. cement, resulting in substantially improved liquefaction of the construction material at a lower dose while pourability can be maintained over a longer period of time as opposed to naphthalene sulfonates or melamine sulfonates.

  本发明涉及一种聚合物缩合产物，包括A）含有5至10个碳原子或杂原子的芳香或杂芳香化合物，该化合物每个分子平均含有1至300个氧乙烯基团和/或氧丙烯基团，这些基团通过O原子或N原子与芳香或杂芳香化合物连接，以及可选的B）从苯酚、苯醚、萘酚、萘醚、苯胺、呋喃基醇和/或从三聚氰胺（衍生物）、脲（衍生物）和羧酸酰胺中选择的氨基塑料成形剂中选择的芳香化合物，和C）从甲醛、乙酰甲酸和苯甲醛或其混合物中选择的醛，其中苯甲醛可选地含有COOMa、SO3Ma和PO3Ma形式的酸基团，其中M = H、碱金属或碱土金属、铵或有机胺基团，且a = ½、1或2。令人惊讶的是，本发明的聚合物缩合产物可以非常好地液化水泥等水泥基材料，从而在较低剂量下显着改善了建筑材料的液化性能，同时可以保持易倒性，而不像萘磺酸盐或三聚氰胺磺酸盐那样在更长时间内保持易倒性。
• Oxyalkylated quaternary ammonium compounds, processes for production thereof, and plant growth regulating compositions containing said compounds
  申请人：DAI-ICHI KOGYO SEIYAKU CO., LTD.

  公开号：EP0371406A1

  公开（公告）日：1990-06-06

  This invention relates to novel oxyalkylated quaternary ammonium compounds, processes for their production and plant growth regulating compositions containing the same compounds. Each of these oxyalkyl­ated quaternary ammonium compounds consists of an oxyalkylated quaternary ammonium cation and an anion selected from among carboxylic acid residues, amino­sulfonic acid residues and phosphoric acid ester residues. These oxyalkylated quaternary ammonium compounds are least phytotoxic, produce marked growth regulating effects on a broad species of plants and are not easily decomposed by microorganisms.

  本发明涉及新型氧烷化季铵化合物、其生产工艺以及含有相同化合物的植物生长调节组合物。每种氧烷基化季铵化合物都由氧烷基化季铵阳离子和选自羧酸残基、氨基磺酸残基和磷酸酯残基的阴离子组成。这些氧烷基化季铵化合物的植物毒性最小，可对多种植物产生明显的生长调节作用，而且不易被微生物分解。
• Topical skin care compositions comprising starch and quaternary ammonium salt
  申请人：Johnson & Johnson Consumer Companies, Inc.

  公开号：EP2255849A2

  公开（公告）日：2010-12-01

  The present invention relates to a composition in the form of a phase-stable oil-in-water emulsion useful for topical skin care products, where the composition includes a quaternary ammonium salt, from about 0.5 to about 4.5 percent by weight of a starch; and at least 20 percent by weight of a hydrophobic agent, where the concentration of the quaternary ammonium salt plus the starch is from about 1.75 to about 5.5 weight percent, based on total weight of the composition.

  本发明涉及一种用于局部皮肤护理产品的相稳定的水包油乳液形式的组合物，其中该组合物包括季铵盐、约 0.5% 至约 4.5% 重量百分比的淀粉；以及至少 20% 重量百分比的疏水剂，其中季铵盐加淀粉的浓度为约 1.75% 至约 5.5% 重量百分比（基于组合物的总重量）。
• Polishing composition and polishing method using the same
  申请人：FUJIMI INCORPORATED

  公开号：EP2348080A1

  公开（公告）日：2011-07-27

  A polishing composition of the present invention contains an oxidant, an anticorrosive, and a surfactant comprising a compound represented by Chemical Formula 1: One to three of R1 to R5 in Chemical Formula 1 are alkyl groups, alkynyl groups, alkenyl groups, aryl groups, or arylalkylene groups, one is a hydrogen atom or an alkyl group having 1 to 9 carbon atoms, and the remainder are hydrogen atoms. OR6 is oxyethylene, oxypropylene, or a random or block conjugate of oxyethylene and oxypropylene. n is an integer of 1 or more. X is an OSO3- group, an OPO32- group, or an OH group.

  本发明的抛光组合物含有氧化剂、防腐剂和表面活性剂，其中表面活性剂由化学式 1 所代表的化合物组成： 化学式 1 中 R1 至 R5 的一至三个是烷基、炔基、烯基、芳基或芳基亚烷基，一个是氢原子或具有 1 至 9 个碳原子的烷基，其余是氢原子。OR6 是氧乙烯、氧丙烯或氧乙烯和氧丙烯的无规或嵌段共轭物。X 是 OSO3- 基团、OPO32- 基团或 OH 基团。
• Additiv für hydraulisch abbindende Massen
  申请人：Construction Research & Technology GmbH

  公开号：EP2769964A1

  公开（公告）日：2014-08-27

  Die vorliegende Erfindung betrifft ein Additiv für hydraulisch abbindende Massen, umfassend eine wässrige kolloid-disperse Zubereitung wenigstens eines wasserlöslichen Salzes eines mehrwertigen Metallkations, wenigstens einer Verbindung, die ein Anion freizusetzen vermag, das mit dem mehrwertigen Metallkation ein schwerlösliches Salz bildet, und wenigstens eines polymeren Dispergiermittels, das anionische und/oder anionogene Gruppen und Polyetherseitenketten umfasst.

  本发明涉及一种用于水力固化组合物的添加剂，该添加剂包括至少一种多价金属阳离子的水溶性盐的水性胶体分散制剂、至少一种能够释放阴离子的化合物（该阴离子与多价金属阳离子形成稀溶性盐）以及至少一种聚合物分散剂（该聚合物分散剂包含阴离子和/或阴离子基团以及聚醚侧链）。