5-(3-chloro-4-(cyclohexylmethoxy)benzyl)thiazolidine-2,4-dione | 1234322-87-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(3-chloro-4-(cyclohexylmethoxy)benzyl)thiazolidine-2,4-dione
• 英文别名: 5-[[3-chloro-4-(cyclohexylmethoxy)phenyl]methyl]-1,3-thiazolidine-2,4-dione
• CAS: 1234322-87-2
• 化学式: C₁₇H₂₀ClNO₃S
• 分子量: 353.87
• InChiKey: AOBKJNWMHFFRIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-[3-chloro-4-(cyclohexylmethoxy)benzylidene]-1,3-thiazolidine-2,4-dione 、 溶剂黄146 在 cobalt(II) chloride hexahydrate sodium tetrahydroborate 、 水 、 二甲基乙二醛肟 、 sodium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以79%的产率得到5-(3-chloro-4-(cyclohexylmethoxy)benzyl)thiazolidine-2,4-dione
  参考文献：
  名称：

  NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF

  摘要：

  本发明涉及由以下式（I）表示的新型噻唑烷二酮衍生物及其用途。更具体地说，本发明涉及由以下式（I）表示的新型噻唑烷二酮衍生物以及包含其的药物组合物。根据本发明的式（I）的新型噻唑烷二酮衍生物可以通过抑制分解前列腺素的15-羟基前列腺素脱氢酶（15-PGDH）的活性，有效用于预防或治疗心血管疾病、胃肠道疾病和肾脏疾病，同时也用于预防脱发和促进头发生长，以及促进骨生成和伤口愈合。

  公开号：

  US20110269954A1

文献信息

• Thiazolidinedione derivative and use thereof
  申请人：Cho Hoon

  公开号：US08637558B2

  公开（公告）日：2014-01-28

  The present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and the uses thereof. More specifically, the present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and a pharmaceutical composition comprising the same. The novel thiazolidinedione derivatives of formula (I) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins as well as useful for the prevention of hair loss and the stimulation of hair growth, and osteogenic stimulation and wound healing.

  本发明涉及以下式(I)所表示的新型噻唑烷二酮衍生物及其用途。更具体地说，本发明涉及以下式(I)所表示的新型噻唑烷二酮衍生物及其制备的药物组合物。根据本发明的新型噻唑烷二酮衍生物可以有效用于抑制降解前列腺素的15-羟基前列腺素脱氢酶（15-PGDH）的活性，从而预防或治疗心血管疾病、胃肠道疾病和肾脏疾病，并且有助于预防脱发和促进头发生长，以及促进骨生成和伤口愈合。
• US8637558B2
  申请人：——

  公开号：US8637558B2

  公开（公告）日：2014-01-28
• [EN] NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF<br/>[FR] NOUVEAU DÉRIVÉ DE THIAZOLIDINEDIONE ET SES APPLICATIONS
  申请人：IND ACADEMIC COOP

  公开号：WO2010077101A4

  公开（公告）日：2011-01-13

  [EN] The present invention relates to a novel Thiazolidinedione derivative expressed by the following chemical formula (1) and uses thereof. More specifically, the present invention relates to a novel Thiazolidinedione derivative expressed by the following chemical formula (1) and a pharmaceutical composition comprising the same. The novel Thiazolidinedione derivative of the following chemical formula (1) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins, for preventing hair loss while stimulating hair growth, for osteogenic stimulation and for the treatment of burns.
  [FR] La présente invention concerne un nouveau dérivé de thiazolidinedione de formule chimique (1) suivante et ses applications. Plus spécifiquement, la présente invention concerne un nouveau dérivé de thiazolidinedione de formule chimique (1) suivante et une composition pharmaceutique l'incluant. Le nouveau dérivé de thiazolidinedione de formule chimique (1) suivante selon la présente invention peut être employé efficacement dans le traitement prophylactique ou thérapeutique d'une maladie cardio-vasculaire, d'une maladie gastro-intestinale et d'une maladie rénale en inhibant l'activité de la 15-hydroxyprostaglandine déshydrogénase (15-PGDH) qui décompose les prostaglandines, dans la prévention de la chute de cheveux en stimulant la croissance capillaire, dans la stimulation ostéogène et dans le traitement des brûlures.
• [EN] COMPOSITION FOR CONTROLLING HARMFUL ALGAE<br/>[FR] COMPOSITION POUR CONTRÔLER DES ALGUES NUISIBLES
  申请人：IND ACADEMIC COOP

  公开号：WO2010090458A2

  公开（公告）日：2010-08-12

  본 발명은 영양염류로 인한 유해조류의 이상 증식을 방지하기 위한 유해조류 방제용 조성물에 관한 것이다. 보다 구체적으로 본 발명은 하기 화학식 1로 표시되는 화합물 또는 그의 염을 포함하는 유해조류 방제용 조성물에 관한 것이다. 본 발명에 따른 화학식 1의 화합물을 포함하는 조성물은 해양, 하천 또는 강 등에서 녹조 및 적조와 같은 조류의 이상 증식을 유발하는 녹조류, 남조류, 규조류, 유글레노이드류, 편모조류 및 황녹색조류의 생장 및 증식을 억제하는 살조 효과가 우수하므로 녹조 및 적조 피해를 예방하고 수질오염을 방지하는데 매우 유용하게 사용될 수 있다.
• NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF
  申请人：Cho Hoon

  公开号：US20110269954A1

  公开（公告）日：2011-11-03

  The present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and the uses thereof. More specifically, the present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and a pharmaceutical composition comprising the same. The novel thiazolidinedione derivatives of formula (I) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins as well as useful for the prevention of hair loss and the stimulation of hair growth, and osteogenic stimulation and wound healing.

  本发明涉及由以下式（I）表示的新型噻唑烷二酮衍生物及其用途。更具体地说，本发明涉及由以下式（I）表示的新型噻唑烷二酮衍生物以及包含其的药物组合物。根据本发明的式（I）的新型噻唑烷二酮衍生物可以通过抑制分解前列腺素的15-羟基前列腺素脱氢酶（15-PGDH）的活性，有效用于预防或治疗心血管疾病、胃肠道疾病和肾脏疾病，同时也用于预防脱发和促进头发生长，以及促进骨生成和伤口愈合。