3-(t-butoxycarbonyl)-1-vinyl-2-pyrrolidinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-(t-butoxycarbonyl)-1-vinyl-2-pyrrolidinone
• 英文别名: tert-butyl 1-ethenyl-2-oxopyrrolidine-3-carboxylate
• 化学式: C₁₁H₁₇NO₃
• 分子量: 211.261
• InChiKey: ZWLPHMHEARANAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(t-butoxycarbonyl)-1-vinyl-2-pyrrolidinone 、 sodium;hydride 、 2-氯四氢呋喃 在 水 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 1.0h， 以to obtain 9.3 g of pure 3-(tetrahydrofuranyloxycarbonyl)-1-vinyl-2-pyrrolidinone (的产率得到3-(tetrahydrofuranyloxycarbonyl)-1-vinyl-2-pyrrolidinone
  参考文献：
  名称：

  Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom

  摘要：

  提供了保护在3位的N-乙烯基内酰胺衍生物的共聚物，其化学式如下所示。这些共聚物被用作适用于深紫外光刻工艺的光阻材料，因此可以获得高灵敏度和分辨率。此外，可以通过使用光阻材料形成超细电路，并实现PED稳定性的显着提高。

  公开号：

  US06262222B1
• 作为产物：
  描述：

  N-乙烯基吡咯烷酮 、 二碳酸二叔丁酯 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 为溶剂， 生成 3-(t-butoxycarbonyl)-1-vinyl-2-pyrrolidinone
  参考文献：
  名称：

  N-vinyllactam derivatives and polymer thereof

  摘要：

  提供并代表以下公式（I）中3位保护的N-乙烯基内酰胺衍生物。这些被聚合成同聚物和共聚物，用于半导体制造的微光刻。这些聚合物用作适合深紫外工艺的光致抗蚀剂材料，因此可以获得高灵敏度和高分辨率的图像。此外，通过使用发明的光致抗蚀剂，可以形成超细电路，并且可以在图案形成方面实现非凡的改进。

  公开号：

  US05750680A1

文献信息

• Biocompatible resists
  申请人：Gonsalves E. Kenneth

  公开号：US20050014098A1

  公开（公告）日：2005-01-20

  This invention relates to biomaterials, biocompatible photoresists, and electroactive photoresists, and methods to engineer the interactions between biomaterials and cells. In one aspect, this invention provides for modifying surface topography through micro-patterning techniques that require no organic solvent development to reveal the lithographic patterns. Cells can be cultured on these surfaces directly and exhibit strong cell alignment features.

  本发明涉及生物材料、生物相容性光刻胶、电活性光刻胶以及生物材料与细胞之间相互作用的工程方法。一方面，本发明提供了通过微图案技术修改表面形貌的方法，这种技术不需要有机溶剂显影来显示光刻图案。细胞可直接在这些表面上培养，并表现出很强的细胞排列特征。
• US06051678
  申请人：——

  公开号：——

  公开（公告）日：——
• CELL AGGREGATION AND ENCAPSULATION DEVICE AND METHOD
  申请人：Brown University

  公开号：EP1976972B1

  公开（公告）日：2014-03-12
• Cell Aggregation and Encapsulation Device and Method
  申请人：Morgan Jeffrey

  公开号：US20090018033A1

  公开（公告）日：2009-01-15

  The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell-encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided.
• METHODS AND DEVICES FOR ENCAPSULATING CELLS
  申请人：BROWN UNIVERSITY

  公开号：US20130137155A1

  公开（公告）日：2013-05-30

  Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing aggregated cells. Devices for encapsulating aggregates of cells include biocompatible, bio-sustainable substrates compartments and a coating of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and cell-encapsulating compartments.