(2R,3S)-2-amino-3-methyl-4-methylsulfanylbutanoic acid | 103129-09-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,3S)-2-amino-3-methyl-4-methylsulfanylbutanoic acid
• CAS: 103129-09-5
• 化学式: C₆H₁₃NO₂S
• 分子量: 163.241
• InChiKey: JNHATNWAMGXQJQ-RFZPGFLSSA-N

物化性质

• 沸点：
  301.9±37.0 °C(Predicted)
• 密度：
  1.161±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  D-蛋氨酸 、 碘甲烷 在 磷酸吡哆醛 、 α-keto acidmethyltranferase from Streptomyces griseoviridis 、 halide methyltransferase from Burkholderiaxenovorans 、 PLP-dependent d-α-amino acid transaminases 、 sodium phosphate 、 S-(5'-腺苷)-L-高半胱氨酸 作用下， 以 aq. phosphate buffer 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  Asymmetric β‐Methylation of l ‐ and d ‐α‐Amino Acids by a Self‐Contained Enzyme Cascade

  摘要：

  AbstractThis report describes a modular enzyme‐catalyzed cascade reaction that transforms l‐ or d‐α‐amino acids to β‐methyl‐α‐amino acids. In this process an α‐amino acid transaminase, an α‐keto acid methyltransferase, and a halide methyltransferase cooperate in two orthogonal reaction cycles that mediate product formation and regeneration of the cofactor pyridoxal‐5′‐phosphate and the co‐substrate S‐adenosylmethionine. The only stoichiometric reagents consumed in this process are the unprotected l‐ or d‐α‐amino acid and methyl iodide.

  DOI：

  10.1002/anie.201916025

文献信息

• Asymmetric β‐Methylation of <scp>l</scp> ‐ and <scp>d</scp> ‐α‐Amino Acids by a Self‐Contained Enzyme Cascade
  作者：Cangsong Liao、Florian P. Seebeck

  DOI：10.1002/anie.201916025

  日期：2020.4.27

  AbstractThis report describes a modular enzyme‐catalyzed cascade reaction that transforms l‐ or d‐α‐amino acids to β‐methyl‐α‐amino acids. In this process an α‐amino acid transaminase, an α‐keto acid methyltransferase, and a halide methyltransferase cooperate in two orthogonal reaction cycles that mediate product formation and regeneration of the cofactor pyridoxal‐5′‐phosphate and the co‐substrate S‐adenosylmethionine. The only stoichiometric reagents consumed in this process are the unprotected l‐ or d‐α‐amino acid and methyl iodide.