N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine | 608122-30-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine
• 英文别名: N-[1-[(2R,4R,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-3,3-difluoro-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
• CAS: 608122-30-1
• 化学式: C₂₂H₂₉F₂N₃O₅Si
• 分子量: 481.572
• InChiKey: NOSUIDGLJHERQU-SZVBFZGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.41
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine 在 吡啶 、 甲醇 、 2,4,6-三异丙基苯磺酰氯 、 四丁基氟化铵 、 氨 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 74.0h， 生成 (2'-deoxy-2',2'-difluoro-5'-monophosphate-1-dodecylthio-2-decyloxypropyl)cytidine
  参考文献：
  名称：

  Synthesis and Cytotoxic Activity of Two Novel 1-Dodecylthio-2-decyloxypropyl-3-phosphatidic Acid Conjugates with Gemcitabine and Cytosine Arabinoside

  摘要：

  Cytosine arabinoside (ara-C) and gemcitabine (dFdC) are two standard chemotherapy drugs used in the treatment of patients with various cancers. To alter the pharmacokinetic and pharmacodynamic properties of these molecules, we conjugated a synthetic phospholipid to both ara-C and dFdC and investigated their chemotherapeutic potential. The dFdC conjugate had greater cytotoxic activity compared with the ara-C conjugate and demonstrated notable cytotoxicity against all human cell lines tested.

  DOI：

  10.1021/jm020571x
• 作为产物：
  描述：

  吉西他滨 在 咪唑 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine
  参考文献：
  名称：

  Synthesis and Cytotoxic Activity of Two Novel 1-Dodecylthio-2-decyloxypropyl-3-phosphatidic Acid Conjugates with Gemcitabine and Cytosine Arabinoside

  摘要：

  Cytosine arabinoside (ara-C) and gemcitabine (dFdC) are two standard chemotherapy drugs used in the treatment of patients with various cancers. To alter the pharmacokinetic and pharmacodynamic properties of these molecules, we conjugated a synthetic phospholipid to both ara-C and dFdC and investigated their chemotherapeutic potential. The dFdC conjugate had greater cytotoxic activity compared with the ara-C conjugate and demonstrated notable cytotoxicity against all human cell lines tested.

  DOI：

  10.1021/jm020571x

文献信息

• Synthesis and Cytotoxic Activity of Two Novel 1-Dodecylthio-2-decyloxypropyl-3-phosphatidic Acid Conjugates with Gemcitabine and Cytosine Arabinoside
  作者：Richard L. Alexander、Susan L. Morris-Natschke、Khalid S. Ishaq、Ronald A. Fleming、Gregory L. Kucera

  DOI：10.1021/jm020571x

  日期：2003.9.1

  Cytosine arabinoside (ara-C) and gemcitabine (dFdC) are two standard chemotherapy drugs used in the treatment of patients with various cancers. To alter the pharmacokinetic and pharmacodynamic properties of these molecules, we conjugated a synthetic phospholipid to both ara-C and dFdC and investigated their chemotherapeutic potential. The dFdC conjugate had greater cytotoxic activity compared with the ara-C conjugate and demonstrated notable cytotoxicity against all human cell lines tested.