1-deoxy-1-(propylamino)-D-glucitol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-deoxy-1-(propylamino)-D-glucitol
• 英文别名: 1-n-propylamino-1-deoxy-D-glucose；N-propyl glucamine；N-propylglucamine；propylglucamine；N-propyl-glucamine；(2R,3R,4R,5S)-6-(propylamino)hexane-1,2,3,4,5-pentol
• 化学式: C₉H₂₁NO₅
• 分子量: 223.269
• InChiKey: LQSCQLNOFWPOIZ-JQCXWYLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  葡萄糖 在 正丙胺 作用下， 生成 1-deoxy-1-(propylamino)-D-glucitol
  参考文献：
  名称：

  Skin treating cosmetic compositions containing N-polyhydroxyalkyl-amines

  摘要：

  本发明涉及用于皮肤治疗的组合物，其含有按重量计最多25%的一种或多种N-多羟基烷基胺，其通式为##STR1##其中R1为氢、低级烷基、羟基低级烷基或氨基烷基，以及杂环氨基烷基；R与R1相同，但两者不能同时为氢；R2为--CH2OH或--COOH；m为整数3或4；n为整数0，或者当m为3且R2为--CH2OH时，n为1；以及使用该组合物进行皮肤治疗的方法。

  公开号：

  US04021539A1

文献信息

• Novel nitrosourea compounds and process for preparing the same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US04182757A1

  公开（公告）日：1980-01-08

  A nitrosourea compound of the formula: ##STR1## wherein R.sup.1 is alkyl of one to six carbon atoms, hydroxyalkyl of one to six carbon atoms, alkenyl of three to five carbon atoms or alkynyl of three to five carbon atoms, R.sup.2 is aldopentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl, O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl or a group of the formula: --CH.sub.2 (CHOH).sub.n CH.sub.2 OH, and wherein n is zero or an integer of one to four. A method of preparation is disclosed whereby said nitrosourea compound is prepared by the nitrosation of a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent.

  一种硝基脲化合物，化学式如下：##STR1## 其中R.sup.1是碳原子数为1至6的烷基，碳原子数为1至6的羟基烷基，碳原子数为3至5的烯基或碳原子数为3至5的炔基，R.sup.2是醛基五糖苷、醛基五糖苷、醛基六糖苷、O-醛基六糖苷-(1.fwdarw.4)-醛基六糖苷或化学式为：--CH.sub.2 (CHOH).sub.n CH.sub.2 OH的基团，其中n为零或1至4的整数。公开了一种制备方法，通过对化合物的亚硝化来制备所述硝基脲化合物，其中该化合物的化学式如下：##STR2## 其中R.sup.1和R.sup.2与上述相同。该硝基脲化合物可用作抗肿瘤或抗白血病药物。
• ARAMCHOL SALTS
  申请人：GALMED RESEARCH & DEVELOPMENT LTD.

  公开号：US20160304553A1

  公开（公告）日：2016-10-20

  Provided are salts of arachidyl amido cholanoic acid (Aramchol), pharmaceutical compositions including Aramchol salts, methods for their preparation, and methods of use thereof in medical treatment.

  提供了花生醇胺基胆酸盐（Aramchol）的盐类、包括Aramchol盐的药物组合物、其制备方法以及在医疗治疗中使用的方法。
• [EN] LOW DOSE COMPOSITIONS OF ARAMCHOL SALTS<br/>[FR] COMPOSITIONS À FAIBLE DOSE DE SELS D'ARAMCHOL
  申请人：GALMED RES AND DEV LTD

  公开号：WO2016199137A1

  公开（公告）日：2016-12-15

  The present invention relates to salts of arachidyl amido cholanoic acid (Aramchol), pharmaceutical compositions comprising Aramchol salts, methods for their preparation, and methods of use thereof in medical treatment.

  本发明涉及油酸花生酰胺胆酸盐（Aramchol）的盐、含有Aramchol盐的药物组合物、其制备方法以及在医疗治疗中的使用方法。
• USE OF 9-OXOACRIDINE-10-ACETIC ACID, SALTS AND ESTERS THEREOF IN COMBINATION THERAPY OF OVARIAN CANCER
  申请人：SURKOV Kirill Gennadievich

  公开号：US20100087399A1

  公开（公告）日：2010-04-08

  The present invention provides novel methods of combination therapy of ovarian cancer, pharmaceutical kits and combinations of 9-oxoacridine-10-acetic acid and/or salts and/or esters thereof with one or more chemotherapeutic agents. The proposed combination therapy is useful in enhancing the action of chemotherapeutic agents and their proliferative activity on human ovarian cancer cells.

  本发明提供了一种新的卵巢癌联合治疗方法，包括使用9-氧基喹啉-10-乙酸及/或其盐和/或酯与一种或多种化疗药物的药物组合和药物套件。所提出的联合治疗方法对于增强化疗药物的作用和其对人类卵巢癌细胞的增殖活性非常有用。
• [EN] RESOLUTION OF TETRAHYDROFOLIC ACID DERIVATIVES<br/>[FR] SÉPARATION DE DÉRIVÉS D'ACIDE TÉTRAHYDROFOLIQUE
  申请人：WATSON LAB INC

  公开号：WO2013025203A1

  公开（公告）日：2013-02-21

  A process of preparing (6S)-tetrahydrofolic acid derivatives comprising reacting racemic (6RS)-tetrahydrofolic acid derivatives with N-alkyl-D-glucamine, forming N-alkyl-D-glucamine salts of the (6RS)-tetrahydrofolic acid derivatives, isolation of the N-alkyl-D-glucamine salt of the (6S)-tetrahydrofolic acid derivative, removal of the N-alkyl-D-glucamine cation and purification of the (6S)-tetrahydrofolic acid derivative. The purified (6S)-tetrahydrofolic acid derivative can then be converted into the corresponding alkali metal or alkaline earth metal salts.

  制备（6S）-四氢叶酸衍生物的过程包括将外消旋（6RS）-四氢叶酸衍生物与N-烷基-D-葡糖胺反应，形成（6RS）-四氢叶酸衍生物的N-烷基-D-葡糖胺盐，分离出（6S）-四氢叶酸衍生物的N-烷基-D-葡糖胺盐，去除N-烷基-D-葡糖胺阳离子，并纯化（6S）-四氢叶酸衍生物。然后，纯化的（6S）-四氢叶酸衍生物可以转化为相应的碱金属或碱土金属盐。