N-(2-((7-oxo-7H-furo[3,2-g]chromen-9-yl)oxy)ethyl)nicotinamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-(2-((7-oxo-7H-furo[3,2-g]chromen-9-yl)oxy)ethyl)nicotinamide
• 英文别名: N-[2-(7-oxofuro[3,2-g]chromen-9-yl)oxyethyl]pyridine-3-carboxamide
• 化学式: C₁₉H₁₄N₂O₅
• 分子量: 350.331
• InChiKey: FBCMIJSPPQLMBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  90.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  8-甲氧基补骨脂素 在 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 12.5h， 生成 N-(2-((7-oxo-7H-furo[3,2-g]chromen-9-yl)oxy)ethyl)nicotinamide
  参考文献：
  名称：

  Design, synthesis, and vasorelaxation activity of novel imperatorin derivatives

  摘要：

  In this study, a series of novel imperatorin derivatives 7a-7e were designed and synthesized. Their vasorelaxation activities were evaluated by the pharmacological experiments in vitro. Most of the tested compounds exhibited better water solubility and vasorelaxation activity in different degrees, especially 7b and 7c with EC50 values of 2.29 and 2.63M, respectively on mesenteric artery, 7d and 7e with EC50 values of 1.04 and 2.65M, respectively on brain artery. The results indicated that these novel compounds have a potential interest for the development of novel and potent vasorelaxant agents for different kinds of arteries.

  DOI：

  10.1080/10286020.2013.790378

文献信息

• Design, synthesis, and vasorelaxation activity of novel imperatorin derivatives
  作者：Nan Zhou、Jian-Yu He、Tao Wang、Jie Zhang、Huai-Zhen He

  DOI：10.1080/10286020.2013.790378

  日期：2013.6

  In this study, a series of novel imperatorin derivatives 7a-7e were designed and synthesized. Their vasorelaxation activities were evaluated by the pharmacological experiments in vitro. Most of the tested compounds exhibited better water solubility and vasorelaxation activity in different degrees, especially 7b and 7c with EC50 values of 2.29 and 2.63M, respectively on mesenteric artery, 7d and 7e with EC50 values of 1.04 and 2.65M, respectively on brain artery. The results indicated that these novel compounds have a potential interest for the development of novel and potent vasorelaxant agents for different kinds of arteries.