乙二醇二月桂酸酯 | 624-04-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 乙二醇二月桂酸酯
• 中文别名: 十二烷酸-1,2-乙二醇酯；乙二醇二(十二酸)酯
• 英文名称: 2-dodecanoyloxyethyl dodecanoate
• 英文别名: ethane-1,2-diyl didodecanoate；ethylene glycol dilaurate；glycol dilaurate；1,2-bis-lauroyloxy-ethane；1,2-Bis-lauroyloxy-aethan；Aethylenglykol-dilaurat
• CAS: 624-04-4
• 化学式: C₂₆H₅₀O₄
• mdl: MFCD00048426
• 分子量: 426.681
• InChiKey: ZVUNTIMPQCQCAQ-UHFFFAOYSA-N

物化性质

• 熔点：
  50-52°
• 沸点：
  bp20 188°
• 密度：
  0.9581 (rough estimate)
• 溶解度：
  可溶于二氯甲烷（少许）、氯仿（少许）、乙酸乙酯（少许）
• LogP：
  10.411 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  30
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.923
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  乙二醇二月桂酸酯 在 2C₃₃H₃₇N*H₂O₇S₂ 、 水 作用下， 以92%的产率得到月桂酸
  参考文献：
  名称：

  N，N-焦硫酸二芳基铵作为高效逆胶束型酯水解催化剂

  摘要：

  反胶束型N，N-焦硫酸二芳基铵（3-5摩尔％）在无有机溶剂的条件下有效催化酯的水解（最大100 mmol规模）。本方法成功地用于各种酯的水解，而没有碱敏感部分的分解，并且对于α-杂取代的羧酸没有任何光学纯度的损失。

  DOI：

  10.1021/ol301290c
• 作为产物：
  描述：

  环氧乙烷 、 月桂酸 在 氢氧化钾 作用下， 生成 乙二醇二月桂酸酯
  参考文献：
  名称：

  Reaction of ethylene oxide or propylene oxide with long‐chain fatty acids. Mono‐ and diester formation

  摘要：

  摘要环氧乙烷或环氧丙烷与脂肪酸的碱催化反应十分复杂。分离出下列纯化合物：乙二醇单月桂酸酯、乙二醇二月桂酸酯、二乙二醇二月桂酸酯、乙二醇二硬脂酸酯、1,2-丙二醇二月桂酸酯和 1,2-丙二醇二硬脂酸酯。研究表明，环氧丙烷单酯是 1 和 2-单月桂酸酯[C11H23CO2CH2CHOHCH3 和 C11H23CO2CH(CH3)CH2OH]的混合物。

  DOI：

  10.1007/bf02540263

文献信息

• [EN] CYCLODEXTRIN INCLUSION COMPLEXES AND METHODS OF PREPARING SAME<br/>[FR] COMPLEXES D'INCLUSION A BASE DE CYCLODEXTRINE ET LEURS PROCEDES DE PREPARATION
  申请人：DEGUSSA CORP

  公开号：WO2006036159A1

  公开（公告）日：2006-04-06

  Cyclodextrin inclusion complexes and methods for preparing cyclodextrin inclusion complexes. In some embodiments, the method for preparing a cyclodextrin inclusion complex may include dry blending cyclodextrin and an emulsifier to form a dry blend, and combining a solvent and a guest with the dry blend to form a cyclodextrin inclusion complex. In some embodiments, the method for preparing a cyclodextrin inclusion complex may include combining cyclodextrin and an emulsifier to form a first mixture, combining the first mixture with a solvent to form a second mixture, and combining a guest with the second mixture to form a third mixture.

  环糊精包合物和制备环糊精包合物的方法。在某些实施例中，制备环糊精包合物的方法可能包括干混环糊精和乳化剂以形成干混物，然后将溶剂和客体与干混物混合以形成环糊精包合物。在某些实施例中，制备环糊精包合物的方法可能包括将环糊精和乳化剂混合以形成第一混合物，然后将第一混合物与溶剂混合以形成第二混合物，最后将客体与第二混合物混合以形成第三混合物。
• [EN] ADJUVANT CHEMICALS THAT PREVENT DRUG TOLERANCE AND PERSISTER FORMATION BY BACTERIA<br/>[FR] PRODUITS CHIMIQUES ADJUVANTS QUI EMPÊCHENT QUE LES BACTÉRIES DÉVELOPPENT UNE TOLÉRANCE AUX MÉDICAMENTS ET FORMENT DES BACTÉRIES PERSISTANTES
  申请人：LIFEUNIT INC

  公开号：WO2019136287A1

  公开（公告）日：2019-07-11

  Disclosed in certain embodiments is a compound of Formula I: X-Z (I) wherein X is a monosugar or disugar moiety and Z is a C8-20 straight chain alkyl, alkenyl or alkynyl having 1-5 substituents (Y) on the first 6 carbons proximal to the disugar moiety, wherein each Y is independently C1-8 linear alkyl, C3-8 branched alkyl, C3-8 cycloalkyl, halogen, hydroxyl, monocyclic aromatic, monocyclic heteroaromatic, bicyclic aromatic, bicyclic heteroaromatic, tricyclic aromatic, or tricyclic heteroaromatic, wherein each Y is independently optionally substituted with C1-8 linear alkyl, C3-8 branched alkyl, C3-8 cycloalkyl, halogen or hydroxyl and pharmaceutical compositions and methods thereof.

  在某些实施例中，公开了一种式子为X-Z（I）的化合物，其中X是单糖或双糖基团，Z是具有1-5个取代基（Y）的C8-20直链烷基，烯基或炔基，这些取代基位于靠近双糖基团的前6个碳上，其中每个Y独立地是C1-8线性烷基，C3-8支链烷基，C3-8环烷基，卤素，羟基，单环芳香族，单环杂芳香族，双环芳香族，双环杂芳香族，三环芳香族或三环杂芳香族，其中每个Y独立地可以用C1-8线性烷基，C3-8支链烷基，C3-8环烷基，卤素或羟基进行取代，以及其制备的药物组合物和方法。
• Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
  申请人：Panzner Steffen

  公开号：US20080089932A1

  公开（公告）日：2008-04-17

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种由混合脂质组成的两性脂质体，所述混合物包括阳离子型两性分子、阴离子型两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子型和阴离子型两性分子可被电荷化，所述阳离子型和阴离子型两性分子的相应量被选择为在第一个较低的pH下具有过量的正电荷的阳离子型两性分子，在第二个较高的pH下具有过量的负电荷的阴离子型两性分子，且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述的阳离子型和阴离子型两性分子适合在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• ADAMANTANE DERIVATIVE, METHOD FOR PRODUCING SAME, POLYMER USING SAME AS STARTING MATERIAL, AND RESIN COMPOSITION
  申请人：Arai Yoshihisa

  公开号：US20110319584A1

  公开（公告）日：2011-12-29

  Provided are an adamantane derivative represented by the following formula (1), a method for producing the same, a polymer containing an acrylate compound having the adamantane structure represented by formula (1) in a repeat unit, and a functional resin composition which contains the polymer, has excellent alkali developability and substrate adhesiveness, and can improve the resolution and the line edge roughness as a chemically amplified resist sensitive to far-ultraviolet rays represented by KrF excimer laser light, ArF excimer laser light, F 2 excimer laser light or EUV without spoiling fundamental properties thereof as a resist such as pattern forming properties, dry etching resistance, heat resistance and the like. In the formula, R 1 through R 3 , which may be the same or different, each represent a hydrogen atom, an alkyl group having a carbon number of 1 to 3, or a halogen-containing alkyl group; R 4 through R 8 , which may be the same or different, each represent an alkyl group having a carbon number of 1 to 3 or a halogen-containing alkyl group; X, which may be the same or different, represents a hydrogen atom, an alkyl group having a carbon number of 1 to 3, or a alkoxy group having a carbon number of 1 to 3; and n represents 14.

  提供了以下公式（1）所代表的金刚烷衍生物，以及制备该衍生物的方法，包含在重复单元中具有公式（1）所代表的金刚烷结构的丙烯酸酯化合物的聚合物，以及包含该聚合物的功能性树脂组成物。该组成物具有优异的碱性显影性和基板粘附性，作为化学增强的抗Far-UV线（KrF准分子激光光、ArF准分子激光光、F2准分子激光光或EUV）的敏化剂，可以提高分辨率和线边粗糙度，同时不破坏其作为抗性的基本性质，如图案形成性能，干法刻蚀抗性，耐热性等。在公式中，R1至R3，可以相同也可以不同，分别代表氢原子，碳数为1到3的烷基或含卤素的烷基；R4至R8，可以相同也可以不同，分别代表碳数为1到3的烷基或含卤素的烷基；X，可以相同也可以不同，代表氢原子，碳数为1到3的烷基或碳数为1到3的烷氧基；n代表14。