环戊-2-烯-1,4-二醇 | 4157-01-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 环戊-2-烯-1,4-二醇
• 英文名称: cis-cyclopent-4-ene-1,3-diol
• 英文别名: cis-4-cyclopenten-1,3-diol；4-Cyclopentene-1,3-diol；cyclopent-4-ene-1,3-diol
• CAS: 4157-01-1
• 化学式: C₅H₈O₂
• mdl: MFCD00090546
• 分子量: 100.117
• InChiKey: IGRLIBJHDBWKNA-UHFFFAOYSA-N

物化性质

• 沸点：
  80-83 °C
• 密度：
  1.317±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2906199090

反应信息

• 作为反应物：
  描述：

  环戊-2-烯-1,4-二醇 在 chromium(VI) oxide 、 硫酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 4-环戊烯-1,3-二酮
  参考文献：
  名称：

  Reimann; Poschl, Pharmazie, 1995, vol. 50, # 9, p. 589 - 592

  摘要：

  DOI：
• 作为产物：
  描述：

  (1R,4S)-4-[(RS)-(tetrahydropyran-2-yl)oxy]cyclopent-2-en-1-ol 在 对甲苯磺酸一水合物 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 以90%的产率得到环戊-2-烯-1,4-二醇
  参考文献：
  名称：

  Preparation of cis-4-O-protected-2-cyclopentenol derivatives

  摘要：

  本发明涉及一种制备顺式-4-O-保护取代-2-环戊烯醇衍生物的新方法，包括以下步骤：a) 将4-O-保护的2-环戊烯酮溶解于适宜的有机溶剂中；b) 在约-100°C至约20°C的温度下，向该溶液中加入适宜的路易斯酸和适宜的还原剂。顺式-4-O-保护取代-2-环戊烯醇衍生物是制备各种环戊基和环戊烯基嘌呤类似物的有用中间体，这些类似物可作为免疫抑制剂，并用于制备各种前列腺素。

  公开号：

  US05728899A1

文献信息

• Novel Imidazo[4,5-c]Quinoline And Imidazo[4,5-c][1,5]Naphthyridine Derivatives As LRRK2 Inhibitors
  申请人：Pfizer Inc.

  公开号：US20170073343A1

  公开（公告）日：2017-03-16

  The present invention provides novel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives of Formula (I), and the pharmaceutically acceptable salts thereof wherein R 1 , R 1a , R 1b , R 2 , R 4 , R 5 , R 6 , X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

  本发明提供了新颖的咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啉衍生物的化合物(I)及其药学上可接受的盐，其中R1、R1a、R1b、R2、R4、R5、R6、X和Z如规范中所定义。该发明还涉及包含化合物(I)的药物组合物，以及利用这些化合物治疗与LRRK2相关的疾病，如神经退行性疾病包括帕金森病或阿尔茨海默病、癌症、克罗恩病或麻风病。
• New Therapeutic Agents
  申请人：Golding Bernard Thomas

  公开号：US20110224274A1

  公开（公告）日：2011-09-15

  A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.

  式（I）的化合物或式（II）的化合物或其药学上可接受的盐，其中R1-R7和X如描述中所定义，并且这些化合物在治疗中的使用，特别是在治疗癌症或作为MDM2蛋白与p53相互作用的抑制剂。
• Oxaindene derivatives and a process for preparing them as well as medicaments containing them and the use of them
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP0751137A1

  公开（公告）日：1997-01-02

  A subject-matter of the invention are oxaindene derivatives of general formula wherein R1represents a C1-4-alkyl, C1-4-alkoxy or C3-6-cycloalkyl group, R2stands for hydrogen or a C1-4-alkyl or C3-6-cycloalkyl group, R3represents hydrogen or a C1-4-alkyl, C1-4-alkoxy or benzyloxy group, Xmeans hydrogen, an aliphatic C1-4-acyl or benzoyl or naphthoyl group, optionally substituted by 1 or more nitro or C1-4-alkoxy group(s) or a group of formula in which latter R7stands for a C1-4-alkylene group    and R5 and R6each represents a C1-4-alkyl group    or R5 and R6together with the nitrogen atom to which they are attached form a piperidyl or morpholinyl group, A and Btogether form an ethylene or a vinylene group    and nis 1, 2 or 3, and their stereoisomers and their mixtures as well as acid addition salts of these compounds. Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds. They have a strong 5-lipoxygenase enzyme inhibiting activity.

  本发明的主题是一种一般公式的氧吲哚衍生物，其中R1代表C1-4-烷基、C1-4-烷氧基或C3-6-环烷基，R2代表氢或C1-4-烷基或C3-6-环烷基，R3代表氢或C1-4-烷基、C1-4-烷氧基或苄氧基，X代表氢、脂肪族C1-4-酰基或苯甲酰基或萘甲酰基，可选择地被1个或多个硝基或C1-4-烷氧基取代，或者是一个公式中的基团，其中R7代表C1-4-烷基烯基，R5和R6各自代表C1-4-烷基基团，或者R5和R6与它们连接的氮原子一起形成哌啶基或吗啡啉基，A和B一起形成乙烯或乙烯基基团，n为1、2或3，以及它们的立体异构体和它们的混合物，以及这些化合物的酸盐。此外还提供了一种制备这些化合物的方法，包含它们的药物以及这些化合物的用途。它们具有强大的5-脂氧酶酶抑制活性。
• Method for the Production of a Compound, Comprising a Free Hydroxyl Group and a Hydroxyl Group Which is Protected by an Ester Function by Enzymatic Reaction
  申请人：Garel Laurent

  公开号：US20080039635A1

  公开（公告）日：2008-02-14

  The invention relates to a method for the production of a compound comprising a free hydroxyl group and a hydroxyl group which is protected by an ester function by enzymatic reaction, using a lipase EC 3.1.1.3. The invention also relates to the use of the resultant compound as an intermediate for the production of medicaments and pharmaceutical products.

  这项发明涉及一种通过酶反应制备含有自由羟基和被酯功能保护的羟基的化合物的方法，使用脂肪酶EC 3.1.1.3。该发明还涉及将所得化合物用作药物和药品生产的中间体的用途。
• Novel monoesters of cis-cyclopentenediol, process for preparation
  申请人：Kowa Company, Ltd.

  公开号：US04170596A1

  公开（公告）日：1979-10-09

  A novel monoester of cis-cyclopentenediol of the following formula ##STR1## wherein ##STR2## is an optically active acyl moiety. The monoester can be prepared by reacting cis-2-cyclopentene-1,4-diol with an optically active carboxylic acid of the following formula ##STR3## wherein ##STR4## is the same as defined above, or its reactive derivative, and separating the resulting reaction product into the two individual diastereomers. Lactones can be prepared from the monoesters selectively and with commercial advantage.

  以下是中文翻译：一种新的单酯化合物，其化学式如下所示：其中##STR2##为光学活性酰基。该单酯化合物可通过将顺式-2-环戊烯-1,4-二醇与以下化学式的光学活性羧酸反应制备而成：其中##STR4##与上述定义相同，或其反应衍生物，并将产生的反应产物分离成两个单独的对映体。从这些单酯化合物可以有选择性地且具有商业优势地制备内酯。