[2-(hydroxymethyl)phenyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside | 929016-65-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [2-(hydroxymethyl)phenyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside
• 英文别名: (2-hydroxymethyl-phenyl)-(tetra-O-acetyl-β-D-galactopyranoside)；(2-Hydroxymethyl-phenyl)-(tetra-O-acetyl-β-D-galactopyranosid)；[(2R,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[2-(hydroxymethyl)phenoxy]oxan-2-yl]methyl acetate
• CAS: 929016-65-9
• 化学式: C₂₁H₂₆O₁₁
• 分子量: 454.431
• InChiKey: JXSRPCPSXCOKGH-XDWAVFMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  [2-(hydroxymethyl)phenyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 在 盐酸 、 甲醇 、 N-氯代丁二酰亚胺 、 sodium methylate 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 6.66h， 生成
  参考文献：
  名称：

  WO2020141459A5

  摘要：

  公开号：

  WO2020141459A5
• 作为产物：
  描述：

  邻甲基苄醇 在 4-二甲氨基吡啶 、 氢氧化钾 、 sodium tetrahydroborate 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 6.0h， 生成 [2-(hydroxymethyl)phenyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside
  参考文献：
  名称：

  Studies on the Synthesis and Antiproliferative Activities of 13‐cis‐Retinoyl Sugar Derivatives

  摘要：

  New retinoyl sugar derivatives of 13-cis-retinoic acid were synthesized in three ways in this paper in order to enhance pharmacal effects, especially antiproliferative activities of 13-cis-retinoic acid. Their structures were confirmed by IR, H-1-NMR, C-13-NMR, and MS spectra and their antiproliferative activities were determined in vitro using human cancer lines. Results showed that some compounds possessed potential antitumor activities.

  DOI：

  10.1080/07328300600966497

文献信息

• Ratiometric electrochemical detection of β-galactosidase
  作者：Sam A. Spring、Sean Goggins、Christopher G. Frost

  DOI：10.1039/c7ob01593c

  日期：——

  A novel ferrocene-based substrate for the ratiometric electrochemical detection of β-galactosidase was designed and synthesised, exhibiting high sensitivity for β-gal.

  设计并合成了一种基于二茂铁的新型底物，用于比例电化学检测β-半乳糖苷酶，对β-半乳糖苷酶具有高灵敏度。
• Helferich; Gootz, Chemische Berichte, 1932, vol. 65, p. 407
  作者：Helferich、Gootz

  DOI：——

  日期：——
• [EN] COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF<br/>[FR] COMPOSÉS COMPRENANT UN LIEUR CLIVABLE ET LEURS UTILISATIONS
  申请人：INTOCELL INC

  公开号：WO2020141459A1

  公开（公告）日：2020-07-09

  Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.