Octadecanoyloxymethyl octadecanoate | 121819-05-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Octadecanoyloxymethyl octadecanoate
• CAS: 121819-05-4
• 化学式: C₃₇H₇₂O₄
• 分子量: 580.976
• InChiKey: AJDORVSWJRNUEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.9
• 重原子数：
  41
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  chloromethyl stearate 、 左氧氟沙星 在 potassium carbonate 、 四丁基碘化铵 作用下， 以 乙腈 为溶剂， 反应 176.0h， 生成 Octadecanoyloxymethyl octadecanoate 、 (3S)-6-[(octadecanoyloxy)methyl] 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
  参考文献：
  名称：

  Novel lipophilic 7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid derivatives as potential antitumor agents: Improved synthesis and in vitro evaluation

  摘要：

  A convenient route for the synthesis of some acyloxymethyl esters and carboxamides of levofloxacin (LV) with modulated lipophilicity is described. The synthesized compounds were evaluated in vitro for their growth inhibitory effect in five human cancer cell lines. The most efficient LV derivatives (ester 2e and amide 4d) displayed IC50 values in the 0.2-2.2 mu M range, while IC50 values for parent LV ranged between 70 and 622 mu M depending on the cell line. The esters displayed no in vivo toxicity up to 80 mg/kg when administered intraperitoneally. This study thus shows that LV analogs displayed antitumor efficacy, at least in vitro, a feature that appeared to be independent from the lipophilicity of the grafted substituent. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.039

文献信息

• [EN] QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME<br/>[FR] COMPOSÉS DE QUINOLIN-4-ONE ET DE 4(1H)-CINNOLINONE ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：FREQUENCY THERAPEUTICS INC

  公开号：WO2020163816A1

  公开（公告）日：2020-08-13

  The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

  本公开涉及喹啉-4-酮和4(1H)-喹啉酮化合物，以及使用它们诱导干/祖细胞支持细胞自我更新的方法，包括诱导干/祖细胞增殖，同时在子细胞中保持分化为组织细胞的能力。
• [EN] MULTICOMPONENT CRYSTALLINE SYSTEM OF EZETIMIBE AND PROLINE<br/>[FR] SYSTÈME CRISTALLIN À PLUSIEURS COMPOSANTS CONSTITUÉ D'ÉZÉTIMIBE ET DE PROLINE
  申请人：BASF SE

  公开号：WO2013014604A1

  公开（公告）日：2013-01-31

  Provided is a crystalline composition comprising a mixture of a compound of formula 1 (Ezetimibe) and proline or proline derivatives, or a hydrate/solvate thereof, as well as a process for obtaining the same. And a process for the purification of Ezetimibe is also disclosed.

  提供了一种结晶组合物，该组合物包括公式1化合物（依折麦布）和脯氨酸或脯氨酸衍生物的混合物，或其水合物/溶剂化物，以及获得同一组合物的过程。还公开了一种用于纯化依折麦布的过程。
• [EN] BENZENE-1,3,5-TRICARBOXAMIDE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE BENZÈNE-1,3,5-TRICARBOXAMIDE ET UTILISATIONS DE CES DÉRIVÉS
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2016187531A1

  公开（公告）日：2016-11-24

  The present invention relates to compounds, compositions, lipid-like nanoparticles, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a polynucleotide).

  本发明涉及化合物、组合物、类脂样纳米粒子以及用于传递治疗、诊断或预防剂（例如多核苷酸）的方法。
• BLOCK COPOLYMER AND COMPOSITION THEREOF
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1498438A1

  公开（公告）日：2005-01-19

  The present invention provides a block copolymer or a hydrogenated product thereof excellent in low-temperature shrinkability, natural shrinkability, rigidity and the like, excellent in a balance of physical properties such as blocking resistance, resistance to fusion bonding in hot water, impact resistance and the like, and having a few fish eyes (FE's) caused by gels. Further, the invention provides a heat shrinkable film and a heat shrinkable multilayer film suitable for drink container packaging, cap seals and the like, using such a block copolymer or the hydrogenated product thereof. The invention provides a block copolymer having a weight ratio of a vinyl aromatic hydrocarbon and a conjugated diene of 60/40 to 90/10 and a number average molecular weight measured by gel permeation chromatography (GPC) of 30,000 to 500,000, wherein the vinyl aromatic hydrocarbon constituting the block copolymer has a block rate of from 10 to 90% by weight, the vinyl aromatic hydrocarbon polymer blocks constituting the block copolymer have a peak molecular weight within the molecular weight range of 5,000 to 30,000, and 40 to 80% by weight of the vinyl aromatic hydrocarbon polymer blocks have a molecular weight of 35,000 or less.

  本发明提供了一种嵌段共聚物或其氢化产品，具有优异的低温收缩性、自然收缩性、刚性等性能，在耐阻塞性、耐热水熔融粘合性、耐冲击性等物理性能的平衡方面表现出色，并且很少出现由凝胶引起的鱼眼（FE）。此外，本发明还提供了一种热收缩薄膜和一种热收缩多层膜，使用这种嵌段共聚物或其氢化产物，适用于饮料容器包装、瓶盖密封等。本发明提供了一种嵌段共聚物，其乙烯基芳香烃和共轭二烯的重量比为 60/40 至 90/10，凝胶渗透色谱法（GPC）测得的平均分子量为 30,000 至 500,000，其中构成嵌段共聚物的乙烯基芳香烃的嵌段率为 10%至 90%（按重量计）、构成嵌段共聚物的乙烯基芳香烃聚合物嵌段的峰值分子量在 5,000 至 30,000 的分子量范围内，40%至 80%（按重量计）的乙烯基芳香烃聚合物嵌段的分子量在 35,000 或以下。
• ELECTRET SHEET AND PIEZOELECTRIC SENSOR
  申请人：Sekisui Chemical Co., Ltd.

  公开号：EP3118873A1

  公开（公告）日：2017-01-18

  The present invention provides an electret sheet which can maintain a high generated voltage even if a large amount of pressure has been applied. Disclosed is an electret sheet of the present invention including an electrically charged propylene-based resin foam sheet which contains a crosslinked propylene-based resin that includes a propylene-α-olefin random copolymer having a weight average molecular weight of 370,000 to 420,000 at a proportion of 60% by weight or more, and has a gel fraction of 30% to 50% by weight, and in which the average thickness is 90 to 150 µm, and the average number of foam cells in the thickness direction is 2 to 4 cells.

  本发明提供了一种驻极体片材，即使在施加大量压力的情况下也能保持较高的产生电压。本发明公开了一种驻极体片材，包括一种带电的丙烯基树脂泡沫片材，其中含有一种交联丙烯基树脂，该树脂包括重量平均分子量为 370,000 至 420,000 的丙烯-α-烯烃无规共聚物，其重量比例为 60% 或以上，凝胶部分的重量比例为 30% 至 50%，平均厚度为 90 至 150 µm，厚度方向上的泡沫单元的平均数目为 2 至 4 单元。