三氯乙酸五氯苯酯 | 2879-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 三氯乙酸五氯苯酯
• 中文别名: 三氟乙酸五氯苯酯；三氯乙酸五氯苯酯[用于肽合成]；TCA-O-PCP
• 英文名称: pentachlorophenyl trichloroacetate
• 英文别名: Trichlor-essigsaeure-pentachlorphenylester；(2,3,4,5,6-pentachlorophenyl) 2,2,2-trichloroacetate
• CAS: 2879-60-9
• 化学式: C₈Cl₈O₂
• mdl: MFCD00059487
• 分子量: 411.711
• InChiKey: WMUFBMFZOHGUPA-UHFFFAOYSA-N

物化性质

• 熔点：
  129 °C
• 密度：
  1.862
• 稳定性/保质期：
  遵照规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• RTECS号：
  SM6670000
• 海关编码：
  2915400090
• 储存条件：
  存放在阴凉干燥处即可。

反应信息

• 作为反应物：
  描述：

  三氯乙酸五氯苯酯 、 O-(叔丁基)-N-[(苯甲氧基)羰基]-L-酪氨酸 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以77.4%的产率得到N-Z-O-tert-butyl-L-tyrosine pentachlorophenyl ester
  参考文献：
  名称：

  Tikhonov, Yu. N.; Trifonova, O. I.; Baranova, G. V., Journal of general chemistry of the USSR, 1980, vol. 50, # 2, p. 371 - 374

  摘要：

  DOI：
• 作为产物：
  描述：

  五氯酚 、 三氯乙酸 在 乙酸酐 作用下， 生成 三氯乙酸五氯苯酯
  参考文献：
  名称：

  Kamennov,N.A. et al., Journal of applied chemistry of the USSR, 1967, vol. 40, # 3, p. 624 - 627

  摘要：

  DOI：
• 作为试剂：
  描述：

  3,3-二甲基丙烯酸 、 benzyl 2-amino-(R)-4,6-O-benzylidene-2-deoxy-β-D-allopyranoside 在 三氯乙酸五氯苯酯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以95%的产率得到benzyl (R)-4,6-O-benzylidene-2-deoxy-2-(3-methyl-2-butenamido)-β-D-allopyranoside
  参考文献：
  名称：

  Stereoselective synthesis of oxiranes using oxazolidines derived from 2-amino-2-deoxy-d-allose as chiral auxiliaries

  摘要：

  The synthesis of 2,3-epoxyamide derivatives of 2-amino-2-deoxy-D-allose is described. Epoxidation of the corresponding alpha,beta-unsaturated amides with m-CPBA took place with better stereoselectivity when an oxazolidine ring was fused to the 2,3-positions of the sugar molecule. In most cases, both stereoisomers could be isolated and characterized. The stereochemistry of the new stereogenic centers was then determined by cleavage of the,oxirane moiety from the chiral auxiliary, which was also recovered. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00562-6

文献信息

• Antisense molecules and method of controlling expression of gene function by using the same
  申请人：——

  公开号：US20030162739A1

  公开（公告）日：2003-08-28

  An antisense molecule which acts on both directions of the inhibition and expression of a gene function and is capable of on-off switching of a gene function appropriately depending on the external factors (orientation controlling factors); and a method for reversibly controlling the expression of a gene function by using the antisense molecule. Such an antisense molecule, which has at least one sugar-base moiety consisting of sugar and a purine or pyrimidine base bonded thereto via a glucoside bond, can bind to a mRNA/gene and/or dissociate therefrom under the orientation control of the base moiety in the molecule by the orientation controlling factors.

  一种反义分子，可以作用于基因功能的抑制和表达的两个方向，并且能够根据外部因素（定向控制因子）适当地开关基因功能；以及一种通过使用该反义分子可逆地控制基因功能表达的方法。这样的反义分子至少包含一个由糖和通过葡苷键连接到糖上的嘌呤或嘧啶碱基部分，可以通过分子中碱基部分的定向控制因子的定向控制，结合到mRNA/基因上，和/或从中解离。
• Nucleoside derivatives
  申请人：——

  公开号：US20030208050A1

  公开（公告）日：2003-11-06

  Novel nucleoside derivatives represented by the following general formula (1): 1 wherein X is(are) the same or different and each represents a pyrimidine or purine base or a derivative thereof, Y-and Y′ are the same or different and each represents at least one amino acid or amino acid derivative selected from the group consisting of serine, threonine, ornithine, aspartic acid, glutamic acid, lysine, arginine, cysteine, methionine, &dgr;-hydroxylysine, N-aminoethylglycine, N-aminoethylserine, N-aminoethyllysine, N-aminoethylornithine, N-aminoethylaspartic acid, N-aminoethylglutamic acid, homoglutamic acid, &bgr;-thiocarbonylaspartic acid, &ggr;-thiocarbonylglutamic acid, and &dgr;-thiocarbonylhomoglutamic acid, R 1 represents a hydrogen atom or a hydroxyl group, A represents a single bond or a carbonyl or thiocarbonyl group, 1 is an integer of 0 to 5, and n is an integer of 1 to 100.

  以下是通用公式（1）所代表的新型核苷衍生物： 其中X是相同或不同的，每个代表嘧啶或嘌呤碱基或其衍生物，Y和Y'是相同或不同的，每个代表丝氨酸、苏氨酸、鸟氨酸、天冬氨酸、谷氨酸、赖氨酸、精氨酸、半胱氨酸、蛋氨酸、δ-羟基赖氨酸、N-氨基乙基甘氨酸、N-氨基乙基丝氨酸、N-氨基乙基赖氨酸、N-氨基乙基鸟氨酸、N-氨基乙基天冬氨酸、N-氨基乙基谷氨酸、同谷氨酸、β-硫代羰基天冬氨酸、γ-硫代羰基谷氨酸和δ-硫代羰基同谷氨酸，R1代表氢原子或羟基，A代表单键或羰基或硫代羰基，1是0到5的整数，n是1到100的整数。
• Amino-acids and peptides. Part 45. The protection of the thiol function of cysteine and the imidazole-N of histidine by the diphenyl-4-pyridylmethyl group
  作者：Susan Coyle、Allan Hallett、Michael S. Munns、Geoffrey T. Young

  DOI：10.1039/p19810000522

  日期：——

  group, this protection is stable in acid but it is cleaved readily by zinc–acetic acid, by mercury(II) acetate, by iodine, and by electrolytic reduction. N(lm)-Diphenyl-4-pyridylmethyl-L-histidine derivatives (9)–(13) are also reported; the protecting group is again stable to acid but cleaved by hydrogenolysis, by zinc–acetic acid, and by electrolytic reduction, and it has been used in the synthesis

  S-（二苯基-4-吡啶基甲基）-L-半胱氨酸（1）及其衍生物（2）-（7）已制备并用于肽合成。与类似的S-三苯甲基相反，这种保护在酸中是稳定的，但是很容易被锌-乙酸，乙酸汞（II），碘和电解还原裂解。还报道了N（lm）-二苯基-4-吡啶基甲基-L-组氨酸衍生物（9）-（13）；该保护基对酸仍然稳定，但可通过氢解，锌-乙酸和电解还原裂解，并已用于合成L-组氨酸-L-亮氨酸，-L-苯丙氨酸和-甘氨酸。
• Total synthesis of bovine pancreatic ribonuclease A. Part 1. Synthesis of the protected pentadecapeptide ester (positions 110–124)
  作者：Nobutaka Fujii、Haruaki Yajima

  DOI：10.1039/p19810000789

  日期：——

  strategy for the total synthesis of bovine pancreatic ribonuclease (RNase) A is outlined with respect to deprotecting procedures and the selection of methods for the construction of the entire amino-acid sequence of this enzyme. Amino-acid derivatives bearing protecting groups removable by methanesulphonic acid were employed in combination with the TFA-labile Z(OMe) Nα-protecting group. Thirty relatively

  关于脱保护程序和构建该酶整个氨基酸序列的方法的选择，概述了牛胰核糖核酸酶（RNase）A的总合成的主要策略。氨基酸衍生物轴承的保护基团可移除地由甲磺酸中与TFA不稳定Z（OME）N组合物采用α保护基团。选择了三十个相对较小的肽片段作为构建肽主链的基础。C端保护的十五肽酯Z（OMe）-（RNase 110-124）-OBzl是通过三个片段Z（OMe）-Val-His-Phe-Asp（OBzl）-Ala-的连续缩合合成的Ser-Val-OBzl（1），Z（OMe）-Asn-Pro-Tyr-Val-Pro-OH（2）和Z（OMe）-Cys（MBzl）-Glu（OBzl）-Gly-OH（3） ）。
• Internucleobase-Interaction-Directed Self-Assembly of Nanofibers from Homo- and Heteroditopic 1,<i>ω</i>-Nucleobase Bolaamphiphiles
  作者：Toshimi Shimizu、Rika Iwaura、Mitsutoshi Masuda、Takeshi Hanada、Kiyoshi Yase

  DOI：10.1021/ja010201i

  日期：2001.6.1

  that under natural light the chiral rope formation is triggered by photodimerization of trace amounts of the thymine moieties in the T-10-T assemblies. Complementary hydrogen bond formation between the thymine-adenine heterobase pairs was found to prevent such a photoreaction and resulted in no chiral rope formation. The heteroditopic T-12-A bolaamphiphile self-assembled to form supramolecular fibers

  互补的 1,omega-thymine, 1,omega-adenine 和 1,omega-(thymine, adenine) bolaamphiphiles, [N,N'-bis[3-(2,4-dihydroxy-5-methylpyrimidine-1-yl) )丙酰基]1,n-二氨基烷烃 [TnT (n = 10, 11, 12)], N, N'-双[3-(6-氨基嘌呤-9-基)丙酰基]1,n-二氨基烷烃 [AnA (n) = 10, 11, 12)], 和 N-[3-(2,4-dihydroxy-5-methylpyrimidine-1-yl)propionyl], N'-[3-(6-aminopurine-9-yl)propionyl]已经合成了 1,n-二氨基烷烃 [TnA (n = 10, 11, 12)]。已经通过光学显微镜、能量过滤透射电子显微镜、FT-IR 和粉末 X

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