3,3-双(4-羟基苯基)-2H-异吲哚-1-酮 | 6607-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 3,3-双(4-羟基苯基)-2H-异吲哚-1-酮
• 英文名称: 3,3-bis(4-hydroxyphenyl)isoindolin-1-one
• 英文别名: phenolphthalein lactam；3,3-bis-(4-hydroxy-phenyl)-2,3-dihydro-isoindol-1-one；3,3-bis-(4-hydroxy-phenyl)-isoindolin-1-one；3,3-Bis-(4-hydroxy-phenyl)-isoindolin-1-on；3,3-Bis-(p-Hydroxyphenyl)-1-oxo-2,3-dihydro-1H-isoindol；3,3-Bis-(4-hydroxyphenyl)-isoindolinon-(1)；1H-Isoindol-1-one, 2,3-dihydro-3,3-bis(4-hydroxyphenyl)-；3,3-bis(4-hydroxyphenyl)-2H-isoindol-1-one
• CAS: 6607-42-7
• 化学式: C₂₀H₁₅NO₃
• 分子量: 317.344
• InChiKey: HZMZYKRMMFUPMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,3-双(4-羟基苯基)-2H-异吲哚-1-酮 在 吡啶 、 硫酸 、 乙酸酐 、 ammonium hydroxide 作用下， 反应 0.75h， 生成
  参考文献：
  名称：

  Inhibition of classical pathway of complement activation with negative charged derivatives of bisphenol A and bisphenol disulphates

  摘要：

  In order to obtain strong inhibitors of classical pathway of complement activation the low weight negative charged compounds have been investigated. On the basis of bisphenol A anionic derivatives with one or two carboxylic, sulphate and phosphate groups the critical role of negative charged groups for complement-inhibiting activity has been established. It was determined that two sulphate or phosphate groups in the molecule provide the most inhibiting effect. At the next stage a set of bisphenol disulphates of varying structures has been synthesized and investigated. Bulky hydrophobic groups (cyclohexyliden, fluorenyliden, anthronyliden) at the central part of the bisphenol molecule it was found to increase complement-inhibiting activity markedly. The replacement of the ortho-positions to the charged group by halogens or alkyl groups (allyl, propyl) increases the inhibiting effect. It was showed by ELISA that several compounds studied interact with Clq, Cl (r) over bar /Cl (s) over bar components of complement. For the set of bisphenol disulphates the QSAR equation with hydrophobic coefficient and electronic parameters has been formulated. Both hydrophobic and electrostatic interactions it was established to have a great significance for the inhibition of classical pathway of complement activation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.11.056
• 作为产物：
  描述：

  酚酞 在 sodium hydroxide 、 氨 、 N,N'-二环己基碳二亚胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 、 锌 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 132.0h， 生成 3,3-双(4-羟基苯基)-2H-异吲哚-1-酮
  参考文献：
  名称：

  A PRACTICAL METHOD FOR THE SYNTHESIS OF PHENOPHTHALEIN SPIROLACTAMS

  摘要：

  DOI：

  10.1080/00304940109356580

文献信息

• NOVEL EPOXY RESIN AND EPOXY RESIN COMPOSITION COMPRISING THE SAME
  申请人：Chun Hyun-Aee

  公开号：US20120041102A1

  公开（公告）日：2012-02-16

  The present invention relates to a novel epoxy resin having improved heat-resistance, thermal expansion properties and processability, and to a thermosetting resin composition comprising the same. To this end, the present invention provides an epoxy resin of Chemical Formula 1 as disclosed in the Description, an epoxy resin composition comprising the same, and a packaging, substrate and transistor formed thereof. When a composition that contains an epoxy resin with a specific side functional group according to the present invention and/or an epoxy resin with a specific core structure is cured, a filler forms a strong chemical bond with the epoxy resin, thereby maximizing filling effects of the filler for the epoxy resin. Moreover, with the specific core structure, heat resistance and heat expansion properties of a cured product are substantially improved (CTE is reduced), and enhanced glass transition properties, strength and processability are demonstrated.

  本发明涉及一种具有改进的耐热性、热膨胀性和加工性的新型环氧树脂，以及包含该环氧树脂的热固性树脂组合物。为此，本发明提供了一种化学式1的环氧树脂，其详细描述在说明书中披露，以及包含该环氧树脂的环氧树脂组合物，以及由此形成的包装、基板和晶体管。当含有本发明的具有特定侧基团的环氧树脂和/或具有特定核心结构的环氧树脂的组合物被固化时，填料与环氧树脂形成强化学键，从而最大化填料对环氧树脂的填充效果。此外，具有特定核心结构，固化产品的耐热性和热膨胀性得到了显著改善（CTE降低），并表现出增强的玻璃转移性能、强度和加工性。
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  作者：Errera、Gasparini

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  作者：PAPAVA, G. SH.、DOXTURISHVILI, N. S.、ZARKUA, Z. L.、MAJSURADZE, N. A.、ABXAZ+

  DOI：——

  日期：——