methyl 4-cyclooctenecarboxylate | 1129-33-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 4-cyclooctenecarboxylate
• 英文别名: 5-Methoxycarbonyl-cycloocten；4-Cyclooctencarbonsaeure-methylester；methyl (4Z)-cyclooct-4-ene-1-carboxylate
• CAS: 1129-33-5
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: NVLYMDYWKGWODU-IHWYPQMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl 4-cyclooctenecarboxylate 在 吡啶 、 4-二甲氨基吡啶 、 正丁基锂 、 四甲基乙二胺 、 水 、 碳酸氢钠 、 二异丙胺 、 potassium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 、 水 为溶剂， 反应 10.66h， 生成 5-iodo-8-oxo-7-oxabicyclo[4.2.2]decan-1-yl acetate
  参考文献：
  名称：

  [EN] COMPOUNDS FOR FAST AND EFFICIENT CLICK RELEASE
  [FR] COMPOSÉS POUR LIBÉRATION DE CHIMIE CLICK RAPIDE ET EFFICACE

  摘要：

  本发明涉及化合物、组合物、试剂盒及其使用方法，用于生物正交释放反应。特别是，本发明的化合物、组合物和试剂盒可用于实现快速高效的点击释放。本发明的化合物、组合物和试剂盒的应用包括体外和体内应用。

  公开号：

  WO2020256546A1
• 作为产物：
  描述：

  cis-5-Hydroxy-cyclooctancarbonsaeure 在 吡啶 、 过甲酸 、 sodium formate 作用下， 反应 3.0h， 生成 methyl 4-cyclooctenecarboxylate
  参考文献：
  名称：

  Proximity Effects. XLI. Solvolysis of Methyl 5-Tosyloxycyclooctanecarboxylates^1,2

  摘要：

  DOI：

  10.1021/ja01092a020

文献信息

• Studies on bicyclo[3.3.1]nonanes—I
  作者：K.H. Baggaley、J.R. Dixon、J.M. Evans、S.H. Graham

  DOI：10.1016/s0040-4020(01)83314-7

  日期：1967.1

  The acetolysis of 4-cyclooctenylmethyl toluene-p-sulphonate gives rise to bicyclo[4.2.1]non-2-ene, and bicyclo[3.3.1]non-2-ene. The chemistry of the epimeric bicyclo[3.3.1]nonan-2-ols is discussed.

  4-环辛烯基甲基甲苯-对磺酸酯的乙酰化反应生成双环[4.2.1] non-2-ene和双环[3.3.1] non-2-ene。讨论了差向异构双环[3.3.1]壬南-2-醇的化学性质。
• Novel Ring Closure Carbonylation Reaction of 1,5-Cyclooctadiene in the Presence of Pd(II)-Catalysts
  作者：Curtis B. Anderson、Rade Marković

  DOI：10.1135/cccc19922374

  日期：——

  Oxidative carbonylation of 1,5-cyclooctadiene in methylene chloride-methanol mixture, catalyzed by Pd(II)-salts, gave rise to a bicyclic, bifunctional product under mild experimental conditions. The mechanism, involving multiple carbon monoxide and double bond insertions into the Pd(II)-carbon σ-bond, has been proposed, as being consistent with the outcome of this novel ring closure reaction.

  在甲基氯仿-甲醇混合物中，由Pd（II）盐催化的1,5-环辛二烯的氧化羰基化反应在温和的实验条件下形成了一种双环，双功能产物。已经提出了多个一氧化碳和双键插入到Pd（II）-碳σ键的机理，这与这种新型环闭合反应的结果一致。
• Synthesis and utility of ethylene (meth)acrylate copolymers prepared by a tandem ring-opening polymerization hydrogenation strategy
  作者：Sebla Onbulak、Yanzhao Wang、Jacob P. Brutman、Marc A. Hillmyer

  DOI：10.1002/pola.28686

  日期：2017.9.15

  functional cyclooctene were prepared and (co)polymerized using ring‐opening metathesis polymerization. The resulting polymers were hydrogenated to yield the corresponding functional polyolefins that were structurally equivalent to copolymers of ethylene and either methyl methacrylate, t‐butyl acrylate, or acrylic acid after deprotection. The copolymers that incorporate methyl methacrylate into the

  制备了一种新的和一种已建立的功能性环辛烯，并使用开环易位聚合进行了（共）聚合。将所得的聚合物进行氢化，得到相应的官能聚烯烃，在结构上相当于脱保护后的乙烯与甲基丙烯酸甲酯，丙烯酸叔丁酯或丙烯酸的共聚物。将甲基丙烯酸甲酯掺入主链的共聚物用作聚（甲基丙烯酸甲酯）/聚乙烯共混物的相容剂。将丙烯酸叔丁酯掺入骨架的共聚物产生了可以热交联的弹性体。©2017 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2017年，55，3117-3126
• Linear functional copolymers of ethylene with precise and minimum run length distributions and method of making thereof
  申请人：Baugh S. Lisa

  公开号：US20050137369A1

  公开（公告）日：2005-06-23

  The present invention is related to a linear functional polymer having repeating units A, B and D. Unit A represents —CH 2 —, unit B represents and unit D represents where R 1 represents a polar functional group. There are at least four A units separating each B unit, each D unit, and each B and D unit. The value y represents the total number of B units and is an integer greater than or equal to 1. The total number of D units is represented by h and is an integer greater than or equal to 0. And x represents the total number of A units and is an integer sufficient that the molar fraction of the B and D units in the linear functional polymer is represented by a value j defined by the equation: j = y + h x + y + h ≤ 0.032 . The present invention is also directed to a method for preparing such linear functional polymers by copolymerizing a first polar substituted monomer and a second non-polar unsubstituted monomer.

  本发明涉及一种具有重复单元A、B和D的线性功能聚合物。单元A代表—CH2—，单元B代表，单元D代表其中R1代表极性官能团。每个B单元、每个D单元和每个B和D单元之间至少有四个A单元。值y表示B单元的总数，是大于或等于1的整数。D单元的总数由h表示，是大于或等于0的整数。x表示A单元的总数，是一个足够使线性功能聚合物中B和D单元的摩尔分数由方程式j定义的整数，j=y+hx+y+h≤0.032。本发明还涉及一种制备这种线性功能聚合物的方法，通过共聚第一极性取代单体和第二非极性未取代单体。
• Linear functional copolymers of ethylene with precise and minimum run length distributions and methods of making thereof
  申请人：Baugh Lisa S.

  公开号：US20080312393A1

  公开（公告）日：2008-12-18

  The present invention is related to a linear functional polymer having repeating units A, B and D. Unit A represents —CH 2 —, unit B represents and unit D represents where R 1 represents a polar functional group. There are at least four A units separating each B unit, each D unit, and each B and D unit. The value y represents the total number of B units and is an integer greater than or equal to 1. The total number of D units is represented by h and is an integer greater than or equal to 0. And x represents the total number of A units and is an integer sufficient that the molar fraction of the B and D units in the linear functional polymer is represented by a value j defined by the equation: j = y + h x + y + h ≤ 0.032 . The present invention is also directed to a method for preparing such linear functional polymers by copolymerizing a first polar substituted monomer and a second non-polar unsubstituted monomer.

  本发明涉及一种具有重复单元A、B和D的线性功能聚合物。单元A表示—CH2—，单元B表示，单元D表示其中R1表示极性官能团。每个B单元、每个D单元和每个B和D单元之间至少有四个A单元。值y表示B单元的总数，是大于或等于1的整数。D单元的总数由h表示，是大于或等于0的整数。x表示A单元的总数，是一个足够的整数，使得线性功能聚合物中B和D单元的摩尔分数由等式j定义，j=y+hx+y+h≤0.032。本发明还涉及一种通过共聚第一极性取代单体和第二非极性未取代单体制备这种线性功能聚合物的方法。