2-(phenylsulfonylethenesulfonylmethyl)-4,5-dihydrothiazole | 1233528-07-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(phenylsulfonylethenesulfonylmethyl)-4,5-dihydrothiazole
• 英文别名: 2-[[(E)-2-(benzenesulfonyl)ethenyl]sulfonylmethyl]-4,5-dihydro-1,3-thiazole
• CAS: 1233528-07-8
• 化学式: C₁₂H₁₃NO₄S₃
• 分子量: 331.438
• InChiKey: ILGJBCKEVBESFZ-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  123
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(phenylsulfonylethenesulfonylmethyl)-4,5-dihydrothiazole 在 chloroamine-T 、 四氯苯醌 作用下， 以 甲醇 、 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 生成 2-(1',3'-diphenyl-4'-(phenylsulfonyl)pyrazol-5'-ylsulfonylmethyl)-4,5-dihydrothiazole
  参考文献：
  名称：

  Synthesis and antioxidant activity of pyrazolyl-oxazolines/thiazolines and isoxazolyl-oxazolines/thiazolines

  摘要：

  A new class of pyrazolyl/isoxazolyl-oxazolines and thiazolines were synthesized from E-arylsulfonylethenesulfonylacetic acid methyl ester and tested for antioxidant activity. Among the tested compounds, 14b exhibited excellent antioxidant activity when compared with the standard ascorbic acid.

  DOI：

  10.1007/s00044-013-0688-z
• 作为产物：
  描述：

  (E)-phenylsulfonylethenesulfonylaceticacid methyl ester 、 巯基乙胺 在 正丁基锂 、 samarium(III) chloride 作用下， 以 甲苯 为溶剂， 反应 0.5h， 以76%的产率得到2-(phenylsulfonylethenesulfonylmethyl)-4,5-dihydrothiazole
  参考文献：
  名称：

  Synthesis and bioassay of pyrrolyl oxazolines and thiazolines

  摘要：

  A new class of sulfone linked pyrrolyl oxazolines and thiazolines were synthesized from E-arylsulfonyl-ethenesulfonylacetic acid methyl ester and studied their antimicrobial and antioxidant activities. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.04.010

文献信息

• Synthesis and antioxidant activity of pyrazolyl-oxazolines/thiazolines and isoxazolyl-oxazolines/thiazolines
  作者：Adivireddy Padmaja、Chittoor Rajasekhar、Suram Durgamma、Bhumireddy Chinnachennaiahgari Venkatesh、Venkatapuram Padmavathi

  DOI：10.1007/s00044-013-0688-z

  日期：2014.3

  A new class of pyrazolyl/isoxazolyl-oxazolines and thiazolines were synthesized from E-arylsulfonylethenesulfonylacetic acid methyl ester and tested for antioxidant activity. Among the tested compounds, 14b exhibited excellent antioxidant activity when compared with the standard ascorbic acid.
• Synthesis and bioassay of pyrrolyl oxazolines and thiazolines
  作者：V. Padmavathi、K. Mahesh、G. Dinneswara Reddy、A. Padmaja

  DOI：10.1016/j.ejmech.2010.04.010

  日期：2010.7

  A new class of sulfone linked pyrrolyl oxazolines and thiazolines were synthesized from E-arylsulfonyl-ethenesulfonylacetic acid methyl ester and studied their antimicrobial and antioxidant activities. (C) 2010 Elsevier Masson SAS. All rights reserved.