2-甲氧基乙基辛基醚 | 37428-63-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-甲氧基乙基辛基醚
• 英文名称: 2-methoxyethyl octyl ether
• 英文别名: 1-(2-methoxy-ethoxy)-octane；1-Methoxy-2n-octyloxyethan；2,5-Dioxatridecan；1-(2-Methoxyethoxy)octane
• CAS: 37428-63-0
• 化学式: C₁₁H₂₄O₂
• 分子量: 188.31
• InChiKey: BTISGUDGDBUQGG-UHFFFAOYSA-N

物化性质

• 沸点：
  223.0±8.0 °C(Predicted)
• 密度：
  0.845±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙二醇甲醚 、 正辛醛 在 palladium on activated charcoal 氢气 作用下， 100.0 ℃ 、4.0 MPa 条件下， 以95%的产率得到2-甲氧基乙基辛基醚
  参考文献：
  名称：

  An alternative catalytic method to the Williamson's synthesis of ethers

  摘要：

  The synthesis of ethers from alcohols and aldehydes or ketones via the corresponding hemiketals is reported using Pd/C as catalyst, under hydrogen. Good isolated yield (>80%) are obtained.

  DOI：

  10.1016/0040-4039(95)00730-z

文献信息

• Oxidative degradation of oligo(ethylene glycol)-terminated monolayers
  作者：Guoting Qin、Chengzhi Cai

  DOI：10.1039/b911155g

  日期：——

  The observation that oligo(ethylene glycol) (OEG)-terminated monolayers remained highly protein-resistant for a month at 37 °C in PBS buffer while they degraded faster in air can be rationalized by a proposed mechanism formulated from a model study using the first internal hydroperoxide of OEG.

  观察到以低聚（乙二醇）（OEG）端接的单分子层在37°C的PBS缓冲液中保持高度抗蛋白性达一个月，而在空气中降解更快，这一现象可以通过一个基于使用OEG第一个内氢过氧化物的模型研究提出的机制来合理化。
• [EN] CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS<br/>[FR] COMPOSÉS DI-NUCLÉOTIDIQUES CYCLIQUES EN TANT QU'AGONISTES DE STING
  申请人：MERCK SHARP & DOHME

  公开号：WO2017027645A1

  公开（公告）日：2017-02-16

  A class of polycyclic compounds of general formula (II), of general formula (II'), or of general formula (II"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

  提供一类多环化合物，其一般化学式为(II)，一般化学式为(II')或一般化学式为(II")，其中在此处定义了Base1、Base2、Y、Ya、Xa、Xa1、Xb、Xb1、Xc、Xc1、Xd、Xd1、R1、R1a、R2、R2a、R3a、R4、R4a、R5、R6、R6a、R7、R7a、R8和R8a，这些化合物可能作为I型干扰素的诱导剂，特别是作为STING活性剂。还提供了合成和使用这些化合物的方法。
• Fache, Fabienne; Bethmont, Valerie; Jacquot, Laurent, Recueil des Travaux Chimiques des Pays-Bas, 1996, vol. 115, # 4, p. 231 - 238
  作者：Fache, Fabienne、Bethmont, Valerie、Jacquot, Laurent、Lemaire, Marc

  DOI：——

  日期：——
• CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170044206A1

  公开（公告）日：2017-02-16

  A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base 1 , Base 2 , Y, Y a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
• [EN] CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS<br/>[FR] COMPOSÉS DE DI-NUCLÉOTIDE CYCLIQUE EN TANT QU'AGONISTES STING (STIMULATEUR DE GÈNE INTERFÉRON)
  申请人：MERCK SHARP & DOHME

  公开号：WO2017027646A1

  公开（公告）日：2017-02-16

  A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.