(3-Oxo-1,3-diphenylpropyl) piperidine-1-carbodithioate | 32746-67-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (3-Oxo-1,3-diphenylpropyl) piperidine-1-carbodithioate
• CAS: 32746-67-1
• 化学式: C₂₁H₂₃NOS₂
• 分子量: 369.552
• InChiKey: VQSNAROJLAMYOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲醛 在 potassium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 24.5h， 生成 (3-Oxo-1,3-diphenylpropyl) piperidine-1-carbodithioate
  参考文献：
  名称：

  Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents

  摘要：

  A series of novel dithiocarbamates with benzimidazole and chalcone scaffold have been designed synthesised and evaluated for their antimitotic activity. Compounds 4c and 9d display the most promising antimitotic activity with IC50 of 1.66 mu M and 1.52 mu M respectively. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.018

文献信息

• Waste-Free and Environment-Friendly Uncatalyzed Synthesis of Dithiocarbamates under Solvent-Free Conditions
  作者：Najmedin Azizi、Mohammad Saidi、Forogh Ebrahimi、Elham Aakbari、Fezzeh Aryanasab

  DOI：10.1055/s-2007-991085

  日期：——

  A mild, convenient, and practical one-pot procedure for the direct synthesis of dithiocarbamates has been developed by condensation of amines, CS 2 , and a Michael acceptor, under solvent-free conditions at room temperature in good to excellent yields.

  一种温和、方便且实用的直接合成二硫代氨基甲酸酯的一锅法已通过胺、CS 2 和迈克尔受体在室温下的无溶剂条件下缩合而成，收率良好至极好。
• An expedient, fast and competent synthesis of organic dithiocarbamates over nanocrystalline MgO in water at room temperature
  作者：Bikash Karmakar、Julie Banerji

  DOI：10.1016/j.tetlet.2011.09.131

  日期：2011.12

  A new, expeditious, efficient and eco-friendly method for the synthesis of organic dithiocarbamates has been achieved at room temperature using basic nanocrystalline MgO catalyst in aqueous condition. The method has been applied for the synthesis of a range of compounds with variable functionalities in excellent yield and selectivity. (C)2011 Elsevier Ltd. All rights reserved.
• One-Pot Synthesis of Dithiocarbamates Accelerated in Water
  作者：Najmodin Azizi、Fezzeh Aryanasab、Lalleh Torkiyan、Azim Ziyaei、Mohammad Reza Saidi

  DOI：10.1021/jo060048g

  日期：2006.4.1

  Highly efficient one-pot reactions of amines and carbon disulfide with alpha,beta-unsaturated compounds were carried out in water under a mild and green procedure with high yields.
• An efficient four-component synthesis of dithiocarbamate derivatives
  作者：Najmedin Azizi、Meysam Khajeh、Morteza Hasani、Sahar Dezfooli

  DOI：10.1016/j.tetlet.2013.07.124

  日期：2013.9

  An environmentally benign, one-pot, four-component synthesis of chemically and pharmaceutically interesting dithiocarbamate derivatives is reported. The one-pot reaction of various aromatic aldehydes, ketones, aliphatic amines, and carbon disulfide, in the presence of potassium hydroxide in urea-choline chloride deep eutectic solvent or ethanol, leads to the corresponding dithiocarbamates in good to excellent yields. This method provides a convenient and time-saving strategy, with a simple work-up procedure. (c) 2013 Elsevier Ltd. All rights reserved.