IR-806

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: IR-806
• 英文别名: sodium;4-[(2Z)-2-[(2E)-2-[2-chloro-3-[(E)-2-[3,3-dimethyl-1-(4-sulfonatobutyl)indol-1-ium-2-yl]ethenyl]cyclopent-2-en-1-ylidene]ethylidene]-3,3-dimethylindol-1-yl]butane-1-sulfonate
• 化学式: C₃₇H₄₄ClN₂O₆S₂*Na
• 分子量: 735.341
• InChiKey: MIOUAELAUIYKFC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  49
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  137
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  对羟基苯乙胺 、 IR-806 以 N,N-二甲基甲酰胺 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  A near-infrared fluorescent probe for monitoring tyrosinase activity

  摘要：

  为监测酪氨酸酶的活性，开发了一种新的基于氰基的近红外荧光探针。

  DOI：

  10.1039/c001225d

文献信息

• Clickable fluorophores for biological labeling—with or without copper
  作者：Péter Kele、Xiaohua Li、Martin Link、Krisztina Nagy、András Herner、Krisztián Lőrincz、Szabolcs Béni、Otto S. Wolfbeis

  DOI：10.1039/b907741c

  日期：——

  for fluorescent labeling of biomolecules is presented by examples on model frameworks representing major biopolymer building blocks. The versatility of these dyes is presented in cell labeling experiments as well as by labeling the azide modified surface glycans of CHO-cells either by copper catalyzed or copper-free click reaction. These dyes are expected to have a large variety of applications in (bio)orthogonal

  本文介绍了一组新的可点击的荧光团的合成，这些荧光团实际上覆盖了到达近红外区域的整个可见光谱。除了能够参与具有相应功能的经典铜催化的1,3-偶极环加成反应的染料外，我们还制备了含有环辛炔部分的炔烃染料，该炔烃衍生物能够使铜自由键合到叠氮化物上。在代表主要生物聚合物构件的模型框架上，通过实例说明了这些染料对生物分子进行荧光标记的适用性。这些染料的多功能性在细胞标记实验中以及通过铜催化的或无铜的点击反应标记CHO细胞的叠氮化物修饰的表面聚糖上呈现出来。体内和体外。
• Phosphonium-based ionic liquids and uses
  申请人：Del Sesto Rico E.

  公开号：US08920673B2

  公开（公告）日：2014-12-30

  Phosphonium-based room temperature ionic liquids (“RTILs”) were prepared. They were used as matrices for Matrix-Assisted Laser Desorption Ionization (MALDI) mass spectrometry and also for preparing samples of dyes for analysis.

  基于磷的室温离子液体（“RTILs”）已经制备好。它们被用作基质辅助激光解吸离子化质谱（MALDI）和染料样品分析的基质。
• Huge enhancement of upconversion luminescence by broadband dye sensitization of core/shell nanocrystals
  作者：Dongguang Yin、Yumin Liu、Jingxiu Tang、Feifei Zhao、Zhiwen Chen、Tingting Zhang、Xinyu Zhang、Na Chang、Chenglong Wu、Dongwei Chen、Minghong Wu

  DOI：10.1039/c6dt01187j

  日期：——

  The UCL intensity of dye-sensitized UCNCs excited at 820 nm is 800-folds higher than that of pure UCNCs excited at 980 nm.

  染料敏化的UCNCs在820纳米激发时的UCL强度比在980纳米激发时纯UCNCs高出800倍。
• A Zinc-dipicolylethylenediamine Modified Near Infrared Fluorophore for Sensing of ATP
  作者：Michael Schäferling、Thomas Lang、Annette Schnettelker

  DOI：10.1007/s10895-013-1292-9

  日期：2014.1

  The development of fluorescent probes for sensing of anions in biological environments is still a demanding task. Due to the structural versatility of biological active anions there are many challenges to cope with compared to fluoroionophores for the determination of metal cations. This concerns particularly the design of the recognition element, which has to provide a selective response, preferably unaffected by alterations of pH and ionic strength. Polyphosphate anions such as ATP are interesting targets in bioanalysis because they are involved in many enzymatic reactions and bear versatile biological functions. Zinc dipicolylamine complexes attached to fluorophores have been turned out to be promising candidates for ATP sensing with sufficient sensitivity and selectivity. We now report the first NIR probe that responds to ATP based on a zinc dipicolylethylenediamine receptor. It shows a “turn-on” fluorescence behavior which is selective to other polyphosphate species even at high ionic strength of the sample solution.

  开发用于感应生物环境中阴离子的荧光探针仍然是一项艰巨的任务。由于生物活性阴离子的结构多变，与测定金属阳离子的荧光探针相比，需要应对许多挑战。这尤其涉及识别元件的设计，它必须提供选择性反应，最好不受 pH 值和离子强度变化的影响。多磷酸盐阴离子（如 ATP）是生物分析中的有趣目标，因为它们参与了许多酶促反应，具有多种生物功能。附着荧光团的锌二羟胺复合物已被证明是具有足够灵敏度和选择性的 ATP 感测的理想候选物。现在，我们报告了首个基于二烷基乙二胺锌受体的 ATP 近红外探针。它显示出一种 "开启 "荧光行为，即使在样品溶液离子强度较高的情况下，也能对其他多磷酸盐物种产生选择性。
• A near-infrared fluorescent probe for monitoring tyrosinase activity
  作者：Xiaohua Li、Wen Shi、Suming Chen、Jia Jia、Huimin Ma、Otto S. Wolfbeis

  DOI：10.1039/c001225d

  日期：——

  A new cyanine-based near-infrared fluorescent probe has been developed for monitoring tyrosinase activity.

  为监测酪氨酸酶的活性，开发了一种新的基于氰基的近红外荧光探针。