2-环戊氧基苯胺 | 29026-75-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-环戊氧基苯胺
• 英文名称: 2-Cyclopentoxyaniline
• 英文别名: 2-cyclopentyloxy-phenylamine；2-(cyclopentyloxy)aniline；2-Cyclopentoxy-anilin；2-cyclopentyloxyaniline
• CAS: 29026-75-3
• 化学式: C₁₁H₁₅NO
• mdl: MFCD04970988
• 分子量: 177.246
• InChiKey: FNBWQWIPPGLDPD-UHFFFAOYSA-N

物化性质

• 沸点：
  301.1±15.0 °C(Predicted)
• 密度：
  1.104±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  2-环戊氧基苯胺 在 sodium tetrahydroborate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 N-(2-cyclopentyloxyphenyl)-N-[(2,5-dimethoxyphenyl)methyl]-2-fluoroacetamide
  参考文献：
  名称：

  Exploration of the structure–activity relationship of the diaryl anilide class of ligands for translocator protein—potential novel positron emitting tomography imaging agents

  摘要：

  A series of novel ligands based on the diaryl anilide (DAA) class of translocator protein (TSPO) ligands was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved using direct radiolabelling or synthon based labelling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands and will be evaluated further as potential clinical imaging agents. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.093
• 作为产物：
  描述：

  1-cyclopentyloxy-2-nitro-benzene 在 palladium 10% on activated carbon 氢气 作用下， 以 乙醇 为溶剂， 25.0 ℃ 、344.75 kPa 条件下， 反应 6.0h， 以84%的产率得到2-环戊氧基苯胺
  参考文献：
  名称：

  Aryl piperidine amides

  摘要：

  该发明提供了新颖的GlyT2抑制化合物，可用于调节、治疗或预防：焦虑症；需要治疗受伤哺乳动物神经组织的状况；适合通过神经营养因子管理治疗的状况；神经系统紊乱；或肥胖症；与肥胖相关的疾病。

  公开号：

  US20050049239A1

文献信息

• CHROMANE DERIVATIVES AS TRPV3 MODULATORS
  申请人：Lingam V.P. Prasada Rao

  公开号：US20110098316A1

  公开（公告）日：2011-04-28

  The present invention provides chromane derivatives as transient receptor potential vanilloid (TRPV) modulators. In particular, the compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

  本发明提供了作为瞬时受体电位香草醛基（TRPV）调节剂的噻吩衍生物。具体而言，本文描述的化合物对于治疗或预防由TRPV3调节的疾病、症状和/或疾病具有用处。本文还提供了制备本文描述的化合物的方法、用于合成它们的中间体、其药物组合物，以及用于治疗或预防由TRPV3调节的疾病、症状和/或疾病的方法。
• [EN] SUBSTITUTED PYRROLOPYRIMIDINES<br/>[FR] PYRROLOPYRIMIDINES SUBSTITUÉES
  申请人：BAYER PHARMA AG

  公开号：WO2013174743A1

  公开（公告）日：2013-11-28

  The present invention relates to substituted pyrrolopyrimidine compounds general formula I : in which A, X, R1, R2, m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式I的取代吡咯吡嘧啶化合物，其中A、X、R1、R2、m和n如本文所述和定义，以制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和配方，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是治疗或预防高增殖和/或血管生成障碍的疾病，作为唯一药剂或与其他活性成分组合使用。
• [EN] PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE PYRAZOLOPYRIMIDINONE ET LEURS UTILISATIONS
  申请人：ADURO BIOTECH INC

  公开号：WO2019055750A1

  公开（公告）日：2019-03-21

  The present invention relates to pyrazolopyrimidinone compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating autoimmune, inflammatory, and neurodegenerative diseases by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及吡唑吡咪啉酮化合物。本发明还涉及含有这些化合物的药物组合物，以及通过向需要的受试者施用这些化合物和药物组合物来治疗自身免疫、炎症和神经退行性疾病的方法。本发明还涉及利用这些化合物进行研究或其他非治疗目的的用途。
• Process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines
  申请人：GAF Corporation

  公开号：US04216152A1

  公开（公告）日：1980-08-05

  This invention relates to an improved process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines which are useful intermediates in the synthesis of agricultural herbicides. This process of the invention comprises reacting a 2-substituted aniline with N-chloromethylpyrrolidone at about room temperature in the presence of an acid acceptor. Such room temperature alkylation of the aniline prevents excessive side reactions, particularly with a substituent in the 2-position of the aniline, such as an alkenyl group, which is sensitive to alkylating agents which require excessive heating to effective the condensation reaction.

  这项发明涉及一种改进的制备N-(N'-甲基亚丙基吡咯酮)-2-取代苯胺的过程，这些化合物是合成农药除草剂时有用的中间体。该发明的工艺包括在存在酸性受体的情况下，将2-取代苯胺与N-氯甲基吡咯酮在大约室温下反应。这种室温烷基化苯胺的方法可以防止过多的副反应，特别是当苯胺的2-位置存在取代基（如烯基基团）时，这种基团对需要过高加热才能有效进行缩合反应的烷基化试剂特别敏感。
• N-(N'-Methylenepyrrolidonyl)-2-substituted anilines
  申请人：GAF Corporation

  公开号：US04202821A1

  公开（公告）日：1980-05-13

  This invention relates to novel N-(N'-methylenepyrrolidonyl)-2-substituted anilines which are useful intermediates in the synthesis of herbicides. The intermediate compounds of the invention have the formula: ##STR1## Where R is alkyl, C.sub.1 -C.sub.6, alkenyl, C.sub.3 -C.sub.5, alkyleneoxyalkyl, --(CH.sub.2).sub.n OR", where n=1-3, and R" is alkyl, C.sub.1 -C.sub.3, and cycloalkyl, ##STR2## where n'=0-3, R' is hydrogen or alkyl, C.sub.1 -C.sub.3, and, Y is oxygen or sulfur.

  这项发明涉及一种新型的N-(N'-亚甲基吡咯烷基)-2-取代苯胺化合物，这些化合物在除草剂合成中是有用的中间体。该发明的中间体化合物具有以下结构式： 其中R为烷基，C₁-C₆，烯基，C₃-C₅，烷氧基烷基，--(CH₂)ₙOR"，其中n=1-3，R"为烷基，C₁-C₃，和环烷基，##STR2## 其中n'=0-3，R'为氢或烷基，C₁-C₃，Y为氧或硫。