1-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-脯氨酰-L-脯氨酰-L-丙氨酰胺 | 160470-73-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 中文名称: 1-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-脯氨酰-L-脯氨酰-L-丙氨酰胺
• 英文名称: Apstatin
• 英文别名: (2S)-1-[(2S)-1-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carbonyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
• CAS: 160470-73-5
• 化学式: C₂₃H₃₃N₅O₅
• 分子量: 459.546
• InChiKey: YVUUZAPYLPWFHE-HXFGRODQSA-N

物化性质

• 沸点：
  864.3±65.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  159
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2S,3R)-3-(Boc-氨基)-2-羟基-4-苯基丁酸 、 Pro-Pro-Ala-NH2 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三氟乙酸 、 氢氟酸 作用下， 以 二氯甲烷 、 苯甲醚 为溶剂， 反应 1.33h， 生成 1-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-脯氨酰-L-脯氨酰-L-丙氨酰胺
  参考文献：
  名称：

  Prechel; Orawski; Maggiora, Journal of Pharmacology and Experimental Therapeutics, 1995, vol. 275, # 3, p. 1136 - 1142

  摘要：

  DOI：

文献信息

• Thio-containing inhibitors of aminopeptidase P, compositions thereof and method of use
  申请人：Simmons H. William

  公开号：US20070060525A1

  公开（公告）日：2007-03-15

  The present invention is directed to an α thio-containing compound that is capable of inhibiting the enzyme, membrane aminopeptidase P (mAPP or APP), whose natural substrate is bradykinin. The compound is useful as a pharmaceutical agent because by inhibiting bradykinin degradation, the compound allows bradykinin to exert its beneficial effects on the cardiovascular system, to improve renal function, and to improve glucose tolerance and insulin-sensitivity. The present invention is also directed to a pharmaceutical composition comprising the mAPP inhibitor of the present invention and a pharmaceutically acceptable carrier. In another aspect, the present invention is directed to a method of inhibiting bradykinin degradation in a mammalian patient, preferably human, in need of treatment comprising administering to the patient a therapeutically effective amount of an α thio-containing compound of the present invention. The method of the present invention also contemplates the further step of administering to the mammalian patient in need of treatment a therapeutically effective amount of an inhibitor of angiotensin converting enzyme (ACE).

  本发明涉及一种含α硫基的化合物，能够抑制酶、膜氨肽酶P（mAPP或APP），其天然底物为激肽。该化合物可用作药物代理，因为通过抑制激肽降解，使激肽能够在心血管系统上发挥其有益作用，改善肾功能，并改善葡萄糖耐量和胰岛素敏感性。本发明还涉及一种含有本发明mAPP抑制剂和药用可接受载体的药物组合物。另一方面，本发明涉及一种在需要治疗的哺乳动物患者，优选为人类，中抑制激肽降解的方法，包括向患者投予本发明的α硫基化合物的治疗有效量。本发明的方法还包括向需要治疗的哺乳动物患者投予抑制肾素转化酶（ACE）的治疗有效量的进一步步骤。
• AMINOPEPTIDASE P INHIBITORS AND USES THEREOF
  申请人：LOYOLA UNIVERSITY OF CHICAGO

  公开号：EP0835123A1

  公开（公告）日：1998-04-15
• EP0835123A4
  申请人：——

  公开号：EP0835123A4

  公开（公告）日：2001-05-16
• METHODS AND COMPOSITIONS FOR REMOVING, REDUCING, DISPERSING, DISRUPTING OR ERADICATING BIOFILMS AND DETERMINING THE NUMBER OF BACTERIAL POPULATION IN BIOFILM OR A CULTURE CONTAINING BACTERIAL AGGREGATE
  申请人：INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES

  公开号：US20190083619A1

  公开（公告）日：2019-03-21

  Methods for removing, reducing, dispersing, disrupting or eradicating biofilms present on a surface may include contacting the biofilm with a composition including an agent that reduces the potency of an aminopeptidase in the biofilm. The agent may reduce expression, secretion or extracellular activity of the aminopeptidase in the biofilm. The biofilm may be formed by P. aeruginosa or P. stutzeri . The composition may enhance the sensitivity of P. aeruginosa to ciprofloxacin. Methods of determining the number of bacterial population in biofilm or a culture containing bacterial aggregate may include dispersing the bacterial aggregate or biofilm by using a composition comprising exogenous PslG. The number of bacteria may be determined based on the dispersed bacteria.
• US7390789B2
  申请人：——

  公开号：US7390789B2

  公开（公告）日：2008-06-24