毒理性
◉ 母乳喂养期间使用概述：目前没有关于在母乳喂养期间使用琥珀酰胆碱的信息。由于它迅速被消除且口服吸收不良，它不太可能进入婴儿的血液循环或对哺乳婴儿产生任何不良反应。包括琥珀酰胆碱在内的用于剖宫产的全身麻醉方案会延迟第一次哺乳的时间，但琥珀酰胆碱在此结果差异中扮演的角色尚不清楚。
◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。
◉ 对泌乳和母乳的影响：一项对进行剖宫产的女性进行的随机但非盲的研究比较了硬脊膜外麻醉使用布比卡因与全身麻醉使用静脉注射硫喷妥钠4 mg/kg和琥珀酰胆碱1.5 mg/kg诱导，随后使用笑气和异氟醚。与全身麻醉相比，硬脊膜外麻醉的第一次哺乳时间显著缩短（107分钟对228分钟）。这种差异可能是由于麻醉对婴儿的影响，因为全身麻醉组婴儿的Apgar评分、神经学和适应评分显著较低。目前尚不清楚琥珀酰胆碱在此结果差异中起了什么作用。
◉ Summary of Use during Lactation:No information is available on the use of succinylcholine during breastfeeding. Because it is rapidly eliminated and poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. A general anesthetic regimen that included succinylcholine for cesarean section caused a delay in the time to the first breastfeeding, but the part that succinylcholine played in this difference in outcome in unknown.
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:A randomized, but nonblinded, study in women undergoing cesarean section compared epidural anesthesia with bupivacaine to general anesthesia with intravenous thiopental 4 mg/kg and succinylcholine 1.5 mg/kg for induction followed by nitrous oxide and isoflurane. The time to the first breastfeed was significantly shorter (107 vs 228 minutes) with the epidural anesthesia than with general anesthesia. This difference was probably caused by the anesthesia's effects on the infant, because the Apgar and neurologic and adaptive scores were significantly lower in the general anesthesia group of infants. It is not known what part succinylcholine played in this difference in outcome.
来源:Drugs and Lactation Database (LactMed)
