5-(benzylthio)pentanol | 1962-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(benzylthio)pentanol
• 英文别名: 4-(benzylthio)pentan-1-ol；5-Benzylthio-1-pentanol；5-benzylsulfanyl-pentan-1-ol；5-Benzylmercapto-pentan-1-ol；5-Benzylsulfanylpentan-1-ol
• CAS: 1962-44-3
• 化学式: C₁₂H₁₈OS
• 分子量: 210.34
• InChiKey: CAOOPMQVPNHKCM-UHFFFAOYSA-N

物化性质

• 沸点：
  327.8±25.0 °C(Predicted)
• 密度：
  1.053±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(benzylthio)pentanol 在 吡啶 、 氯化亚砜 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以71%的产率得到5-(benzylthio)pentyl chloride
  参考文献：
  名称：

  Jursic, Branco; Ladika, Mladen; Sunko, Dionis E., Gazzetta Chimica Italiana, 1988, vol. 118, # 9, p. 613 - 616

  摘要：

  DOI：
• 作为产物：
  描述：

  苄硫醇 在 硼烷四氢呋喃络合物 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 53.0h， 生成 5-(benzylthio)pentanol
  参考文献：
  名称：

  A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

  摘要：

  Divergent synthesis of two novel C-glycosidic multivalent mannosides derived from a common trivalent C-mannosyl carboxylate-terminated intermediate is described. This illustrates synthesis of multivalent C-glycosidic architectures bearing variable extended functionalized tethers. One such tether incorporates an embedded fluorescent unit providing a C-mannosyl multivalent epitope offering potential applications through further conjugation or immobilization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.047

文献信息

• Visible-Light-Mediated Organocatalyzed Thiol–Ene Reaction Initiated by a Proton-Coupled Electron Transfer
  作者：Vitalij V. Levin、Alexander D. Dilman

  DOI：10.1021/acs.joc.9b01331

  日期：2019.6.21

  A convenient method for performing a thiol–ene reaction is described. The reaction is performed under blue-light irradiation and catalyzed by photoactive Lewis basic molecules such as acridine orange or naphthalene-fused N-acylbenzimidazole. It is believed that the process is initiated by a proton-coupled electron transfer process within the complex between the thiol and the Lewis basic catalyst.

  描述了一种进行硫醇-烯反应的简便方法。该反应在蓝光照射下进行，并由光活性的路易斯碱性分子如a啶橙或萘稠合的N-酰基苯并咪唑催化。据信该过程是由硫醇和路易斯碱性催化剂之间的配合物中的质子偶联电子转移过程引发的。
• [EN] STABLE VACCINE AGAINST CLOSTRIDIUM DIFFICILE<br/>[FR] VACCIN STABLE DIRIGÉ CONTRE CLOSTRIDIUM DIFFICILE
  申请人：VAXXILON AG

  公开号：WO2020104697A1

  公开（公告）日：2020-05-28

  The present invention relates to a synthetic saccharide of general formula (I) that is related to Clostridium difficile PS-II cell-surface polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Clostridium difficile. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Clostridium difficile bacteria.

  本发明涉及一种与Clostridium difficile PS-II细胞表面多糖及其共轭物相关的通用式(I)的合成糖苷。所述合成糖苷，所述共轭物以及含有所述合成糖苷或所述共轭物的药物组合物对于预防和/或治疗与Clostridium difficile相关的疾病是有用的。此外，通用式(I)的合成糖苷在免疫学检测中作为标记物是有用的，用于检测针对Clostridium difficile细菌的抗体。
• Photogeneration of thiyl radicals using metal‐halide perovskite for highly efficient synthesis of thioethers
  作者：Xin Liu、Rong Bai、Zhifen Guo、Yan Che、Chunyi Guo、Hongzhu Xing

  DOI：10.1002/aoc.6492

  日期：2022.2

  generation of thiyl radicals via hole oxidation to initiate the reaction, followed by redox neutral pathway and/or chain transfer pathway to accomplish thiol–olefin coupling. It is notable that CsPbBr3 exhibits advanced thiol-ene performance than that using MHP analogs and others. The work presents a new exploration of MHP-mediated transformation and shows great potential of MHPs for radical chemistry

  最近，金属卤化物钙钛矿（MHP）在光诱导有机物转化中的应用引起了广泛关注。我们在此报告了使用 CsPbBr 3纳米晶体的无机 MHP 开发的光诱导硫醇-烯反应，该反应具有可见光响应性、易于制备和成本效益。在蓝色发光二极管 (LED) 下，一系列硫醇底物被证明是与具有各种官能团的烯烃偶联的高效反应伙伴，从而提供含有 C-S 键的多种硫醚。CsPbBr 3介导的硫醇-烯反应具有高效、底物适用性广、产率高、条件温和等特点。机理研究表明，可见光激发的 CsPbBr 3通过空穴氧化诱导硫自由基的产生以引发反应，然后通过氧化还原中性途径和/或链转移途径来完成硫醇-烯烃偶联。值得注意的是，与使用 MHP 类似物和其他材料相比，CsPbBr 3表现出先进的硫醇烯性能。该工作对 MHP 介导的转化进行了新的探索，并展示了 MHP 在自由基化学中的巨大潜力。
• Vaccine against Klebsiella pneumoniae
  申请人：Idorsia Pharmaceuticals Ltd

  公开号：US11479574B2

  公开（公告）日：2022-10-25

  The present invention relates to a synthetic saccharide of general formula (I) that is related to Klebsiella pneumoniae serotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistant Klebsiella pneumoniae ST258 O-polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Klebsiella pneumoniae. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Klebsiella pneumoniae bacteria.

  本发明涉及一种与肺炎克雷伯菌血清型O1、O2、O2ac和O8 O-多糖以及耐碳青霉烯类肺炎克雷伯菌ST258 O-多糖有关的通式（I）合成糖及其共轭物。所述合成糖、所述共轭物和含有所述合成糖或所述共轭物的药物组合物可用于预防和/或治疗与肺炎克雷伯氏菌相关的疾病。此外，通式（I）的合成糖苷可作为免疫学试验中的标记物，用于检测针对肺炎克雷伯氏菌的抗体。
• Reductions with Metal Hydrides. XV. Reduction of 2-Tetrahydropyranyl and 2-Tetrahydrofuranyl Thioethers with Lithium Aluminum Hydride- Aluminum Chloride
  作者：Ernest L. Eliel、Bernard E. Nowak、Ronald A. Daignault

  DOI：10.1021/jo01018a083

  日期：1965.7