2-[(1S)-1-[2-(4-methylpiperazin-1-yl)acetyl]oxypentyl]benzoic acid | 1428866-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(1S)-1-[2-(4-methylpiperazin-1-yl)acetyl]oxypentyl]benzoic acid
• CAS: 1428866-50-5
• 化学式: C₁₉H₂₈N₂O₄
• 分子量: 348.442
• InChiKey: RTYRCZGJXXMOHU-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[(1S)-1-[2-(4-methylpiperazin-1-yl)acetyl]oxypentyl]benzoic acid 在 4-二甲氨基吡啶 、 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、310.27 kPa 条件下， 反应 12.17h， 生成 2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol
  参考文献：
  名称：

  Novel Hybrids of Optically Active Ring-Opened 3-n-Butylphthalide Derivative and Isosorbide as Potential Anti-Ischemic Stroke Agents

  摘要：

  In search of novel anti-ischemic stroke agents with higher potency than a known drug 3-n-butylphthalide (NBP), a series of hybrids ((S)- and (R)-5a-f) from optically active ring-opened NBP derivative and isosorbide were synthesized for evaluating their anti-ischemic stroke activity. Compound (S)-5e displayed the strongest activity in inhibiting the adenosine diphosphate (ADP) and arachidonic acid (AA)-induced platelet aggregation in vitro, with 10.0- and 8.4-fold more effectiveness than (S)-NBP, respectively. Furthermore, (S)-5e was stable in artificial gastrointestinal fluids and could penetrate the blood-brain barrier (BBB) with an appreciate lipid/water partition coefficient relative to (S)-NBP. More importantly, oral treatment with (S)-5e protected from acute thrombosis and inhibited the ischemia/reperfusion-related brain injury in animals. Our findings suggest that (S)-5e may be promising for further evaluation for the intervention of ischemic stroke.

  DOI：

  10.1021/jm4001693
• 作为产物：
  描述：

  3-丁基-1(3H)-异苯并呋喃酮 在 4-二甲氨基吡啶 、 potassium carbonate 、 三乙胺 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 15.0h， 生成 2-[(1S)-1-[2-(4-methylpiperazin-1-yl)acetyl]oxypentyl]benzoic acid
  参考文献：
  名称：

  Novel Hybrids of Optically Active Ring-Opened 3-n-Butylphthalide Derivative and Isosorbide as Potential Anti-Ischemic Stroke Agents

  摘要：

  In search of novel anti-ischemic stroke agents with higher potency than a known drug 3-n-butylphthalide (NBP), a series of hybrids ((S)- and (R)-5a-f) from optically active ring-opened NBP derivative and isosorbide were synthesized for evaluating their anti-ischemic stroke activity. Compound (S)-5e displayed the strongest activity in inhibiting the adenosine diphosphate (ADP) and arachidonic acid (AA)-induced platelet aggregation in vitro, with 10.0- and 8.4-fold more effectiveness than (S)-NBP, respectively. Furthermore, (S)-5e was stable in artificial gastrointestinal fluids and could penetrate the blood-brain barrier (BBB) with an appreciate lipid/water partition coefficient relative to (S)-NBP. More importantly, oral treatment with (S)-5e protected from acute thrombosis and inhibited the ischemia/reperfusion-related brain injury in animals. Our findings suggest that (S)-5e may be promising for further evaluation for the intervention of ischemic stroke.

  DOI：

  10.1021/jm4001693

文献信息

• Novel Hybrids of Optically Active Ring-Opened 3-<i>n</i>-Butylphthalide Derivative and Isosorbide as Potential Anti-Ischemic Stroke Agents
  作者：Xiaoli Wang、Linna Wang、Tingting Li、Zhangjian Huang、Yisheng Lai、Hui Ji、Xiaolong Wan、Jinyi Xu、Jide Tian、Yihua Zhang

  DOI：10.1021/jm4001693

  日期：2013.4.11

  In search of novel anti-ischemic stroke agents with higher potency than a known drug 3-n-butylphthalide (NBP), a series of hybrids ((S)- and (R)-5a-f) from optically active ring-opened NBP derivative and isosorbide were synthesized for evaluating their anti-ischemic stroke activity. Compound (S)-5e displayed the strongest activity in inhibiting the adenosine diphosphate (ADP) and arachidonic acid (AA)-induced platelet aggregation in vitro, with 10.0- and 8.4-fold more effectiveness than (S)-NBP, respectively. Furthermore, (S)-5e was stable in artificial gastrointestinal fluids and could penetrate the blood-brain barrier (BBB) with an appreciate lipid/water partition coefficient relative to (S)-NBP. More importantly, oral treatment with (S)-5e protected from acute thrombosis and inhibited the ischemia/reperfusion-related brain injury in animals. Our findings suggest that (S)-5e may be promising for further evaluation for the intervention of ischemic stroke.