[4-[(5S,5aR,8aR,9R)-5-ethylsulfanyl-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] benzyl carbonate | 270071-30-2

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素内酯
• 英文名称: [4-[(5S,5aR,8aR,9R)-5-ethylsulfanyl-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] benzyl carbonate
• CAS: 270071-30-2
• 化学式: C₃₁H₃₀O₉S
• 分子量: 578.64
• InChiKey: BUKITVKXRKYBJR-XNLUEZIFSA-N

物化性质

• 沸点：
  753.3±60.0 °C(Predicted)
• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  [4-[(5S,5aR,8aR,9R)-5-ethylsulfanyl-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] benzyl carbonate 在 palladium on activated charcoal 氢气 、 trifluoromethanesulfonic acid anhydride 、 间氯过氧苯甲酸 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， -78.0~-40.0 ℃ 、344.75 kPa 条件下， 反应 17.08h， 生成 依托泊苷
  参考文献：
  名称：

  Novel “Reverse Kahne-Type Glycosylation”:  Access to O-, N-, and C-Linked Epipodophyllotoxin Conjugates

  摘要：

  Exposure of epipodophyllotoxin C-4-sulfoxides to triflic anhydride, followed by a silyl glycoside, provides a glycoconjugate of the etoposide variety via formal "reverse Kahne glycosylation," To our knowledge, this is the first example of this variant of the Kahne activation method wherein the activating functionality is positioned on the aglycon, rather than on the sugar. Phenols, anilines, or allyl silanes are also efficiently captured at C-4, producing the corresponding O-, N, and C linked lignan conjugates.

  DOI：

  10.1021/ol005732a
• 作为产物：
  描述：

  4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin 、 乙硫醇 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以94%的产率得到[4-[(5S,5aR,8aR,9R)-5-ethylsulfanyl-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] benzyl carbonate
  参考文献：
  名称：

  Novel “Reverse Kahne-Type Glycosylation”:  Access to O-, N-, and C-Linked Epipodophyllotoxin Conjugates

  摘要：

  Exposure of epipodophyllotoxin C-4-sulfoxides to triflic anhydride, followed by a silyl glycoside, provides a glycoconjugate of the etoposide variety via formal "reverse Kahne glycosylation," To our knowledge, this is the first example of this variant of the Kahne activation method wherein the activating functionality is positioned on the aglycon, rather than on the sugar. Phenols, anilines, or allyl silanes are also efficiently captured at C-4, producing the corresponding O-, N, and C linked lignan conjugates.

  DOI：

  10.1021/ol005732a

文献信息

• Novel “Reverse Kahne-Type Glycosylation”:  Access to O-, N-, and C-Linked Epipodophyllotoxin Conjugates
  作者：David B. Berkowitz、Sungjo Choi、Debnath Bhuniya、Richard K. Shoemaker

  DOI：10.1021/ol005732a

  日期：2000.4.1

  Exposure of epipodophyllotoxin C-4-sulfoxides to triflic anhydride, followed by a silyl glycoside, provides a glycoconjugate of the etoposide variety via formal "reverse Kahne glycosylation," To our knowledge, this is the first example of this variant of the Kahne activation method wherein the activating functionality is positioned on the aglycon, rather than on the sugar. Phenols, anilines, or allyl silanes are also efficiently captured at C-4, producing the corresponding O-, N, and C linked lignan conjugates.