10-[11C]methoxy-20(S)-camptothecin

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: 10-[11C]methoxy-20(S)-camptothecin
• 英文别名: (19S)-19-ethyl-19-hydroxy-7-(111C)methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• 化学式: C₂₁H₁₈N₂O₅
• 分子量: 377.373
• InChiKey: KLFJSYOEEYWQMR-QMXODZCDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  10-羟基喜树碱 、 [11C]methyl triflate 在 四丁基氢氧化铵 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 0.1h， 生成 10-[11C]methoxy-20(S)-camptothecin
  参考文献：
  名称：

  Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers

  摘要：

  Four carbon-11-labeled camptothecin derivatives, 9-[C-11]methoxy-20(S)-camptothecin ([C-11]5), 10-[C-11]methoxy-20(S)-camptothecin ([C-11]7), 9-nitro-10-[C-11]methoxy-20(S)-camptothecin ([C-11]9), and 9-[([C-11]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([C-11]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.108

文献信息

• Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers
  作者：Mingzhang Gao、Kathy D. Miller、George W. Sledge、Qi-Huang Zheng

  DOI：10.1016/j.bmcl.2005.05.108

  日期：2005.9

  Four carbon-11-labeled camptothecin derivatives, 9-[C-11]methoxy-20(S)-camptothecin ([C-11]5), 10-[C-11]methoxy-20(S)-camptothecin ([C-11]7), 9-nitro-10-[C-11]methoxy-20(S)-camptothecin ([C-11]9), and 9-[([C-11]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([C-11]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers. (c) 2005 Elsevier Ltd. All rights reserved.