毒理性
3-硝基丙酸是琥珀酸脱氢酶的自杀性抑制剂,琥珀酸脱氢酶是三羧酸循环以及电子传递链的线粒体呼吸复合物II所需的一种酶。它与Arg297的侧链形成共价加成物,使琥珀酸脱氢酶失活。这通过导致NMDA受体激活、过量的钙离子流入和活性氧物种的形成,最终导致神经细胞死亡,从而影响神经元。(A2967, A2968)
3-Nitropropionic acid is a suicide inhibitor of succinate dehydrogenase, an enzyme required for the activity of the tricarboxylic acid (TCA) cycle as well as mitochondrial respiratory complex II of the electron transport chain. It forms a covalent adduct with the side chain of Arg297, inactivating the succinate dehydrogenase. This affects neurons by leading to NMDA-receptor activation, excessive calcium influx, and formation of reactive oxygen species, eventually causing neuronal cell death. (A2967, A2968)
来源:Toxin and Toxin Target Database (T3DB)