methyl 3-(4-(phenylamino)phenyl)propanoate | 525589-19-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(4-(phenylamino)phenyl)propanoate
• 英文别名: Methyl 3-(4-anilinophenyl)propanoate
• CAS: 525589-19-9
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: OJNFJDHJGHRQBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 3-(4-(phenylamino)phenyl)propanoate 在 4-二甲氨基吡啶 、 sodium hydroxide 、 草酰氯 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 70.0h， 生成 tert-butyl 4-(3-oxo-3-(5-(pyridin-2-yl)oxazol-2-yl)propyl)phenyl(phenyl)carbamate
  参考文献：
  名称：

  Structure−Activity Relationships of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

  摘要：

  A systematic study of the structure-activity relationships of 2b (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed targeting the C2 acyl side chain. A series of aryl replacements or substituents for the terminal phenyl group provided effective inhibitors (e.g., 5c, aryl = 1- napthyl, K-i = 2.6 nM), with 5hh (aryl = 3-ClPh, K-i = 900 pM) being 5-fold more potent than 2b. Conformationally restricted C2 side chains were examined, and many provided exceptionally potent inhibitors, of which 11j (ethylbiphenyl side chain) was established to be a 750 pM inhibitor. A systematic series of heteroatoms (O, NMe, S), electron-withdrawing groups (SO, SO2), and amides positioned within and hydroxyl substitutions on the linking side chain were investigated, which typically led to a loss in potency. The most tolerant positions provided effective inhibitors (12p, 6-position S, K-i = 3 nM, or 13d, 2-position OH, K-i = 8 nM) comparable in potency to 2b. Proteome-wide screening of selected inhibitors from the systematic series of > 100 candidates prepared revealed that they are selective for FAAH over all other mammalian serine proteases.

  DOI：

  10.1021/jm061414r
• 作为产物：
  描述：

  对硝基肉桂酸 在 palladium 10% on activated carbon 、 copper diacetate 、 肉豆蔻酸 2,6-二甲基吡啶 、 硫酸 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 反应 58.0h， 生成 methyl 3-(4-(phenylamino)phenyl)propanoate
  参考文献：
  名称：

  WO2008/147553

  摘要：

  公开号：

文献信息

• Novel Carbazole Compound, and Polymer Thereof
  申请人：HIROSE Hidekazu

  公开号：US20080312453A1

  公开（公告）日：2008-12-18

  The present invention provides a carbazole compound represented by the following formula (I): wherein each Ar 1 independently represents a substituted or unsubstituted monovalent aromatic group or an aromatic group containing a heteroring, and R 1 and each R 2 independently represent a hydrogen atom, an alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group.

  本发明提供了一种由下式(I)表示的咔唑化合物：其中，每个Ar1独立地表示一个取代的或未取代的单价芳香族基团或含杂环的芳香族基团，R1和每个R2独立地表示一个氢原子、一个烷基、一个取代的或未取代的芳基或一个取代的或未取代的芳烷基。
• 化合物、电荷输送膜、光电转换装置和电子照 相感光体
  申请人：富士施乐株式会社

  公开号：CN102952030B

  公开（公告）日：2016-02-24

  本发明提供了一种化合物、电荷输送膜、光电转换装置和电子照相感光体。所述化合物为由以下通式(I)表示的反应性化合物，其中，在通式(I)中，F表示电荷输送骨架，D表示由以下通式(III)表示的基团，并且m表示1～8的整数。在通式(III)中，L1表示包含一个或多个-C(＝O)-O-基团的二价连接基团。
• Thiazolothiazole compound and thiazolothiazole polymer
  申请人：Fuji Xerox Co., Ltd.

  公开号：US08207348B2

  公开（公告）日：2012-06-26

  The invention provides a thiazolothiazole compound represented by the following Formula (I). In Formula (I), Ar1 represents a substituted or unsubstituted aromatic group; R1 represents a hydrogen atom, an alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; and n represents an integer of 0 or 1. The invention further provides a thiazolothiazole polymer having the thiazolothiazole compound as a polymerization unit thereof.

  该发明提供了以下式（I）所表示的噻唑噻唑化合物。在式（I）中，Ar1代表取代或未取代的芳香基团；R1代表氢原子、烷基、取代或未取代的芳基团，或取代或未取代的芳基烷基团；n代表0或1的整数。该发明还提供了一种以该噻唑噻唑化合物作为聚合单元的噻唑噻唑聚合物。
• QUINOXALINE-CONTAINING COMPOUNDS AND POLYMERS THEREOF
  申请人：HORIBA Koji

  公开号：US20080306239A1

  公开（公告）日：2008-12-11

  There is provided a quinoxaline-containing compound represented by the following formula (I); wherein Ar 1 represents a substituted or unsubstituted monovalent aromatic group; and R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group.

  提供一种含有喹啉基的化合物，其化学式如下（I）；其中Ar1代表一个取代或未取代的一价芳香基团；而R1代表氢原子、取代或未取代的烷基团、取代或未取代的芳基团，或取代或未取代的芳基烷基团。
• Thiophene-containing compound and thiophene-containing compound polymer
  申请人：Ohba Yoshihiro

  公开号：US20050059730A1

  公开（公告）日：2005-03-17

  The present invention relates to a thiophene-containing compound and a thiophene-containing compound polymer which are useful for organo-electronic devices such as electrophotographic photoreceptors (photosensitive elements), organic electroluminescent elements and organic transistors. More specifically, the invention relates to a thiophene-containing compound and a thiophene-containing compound polymer which are excellent in terms of both charge-transporting properties and luminous properties.

  本发明涉及一种含噻吩的化合物和含噻吩的化合物聚合物，它们可用于有机电子器件，如电子照相感光体（感光元件），有机电致发光元件和有机晶体管。更具体地说，本发明涉及一种含噻吩的化合物和一种含噻吩的化合物聚合物，在电荷传输性能和发光性能方面均表现出优异的性能。