2-吗啉-4-基-1,3-噻唑-4(5h)-酮 | 16781-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 2-吗啉-4-基-1,3-噻唑-4(5h)-酮
• 英文名称: 2-morpholino-thiazolin-4-one
• 英文别名: 2-morpholin-4-yl-2-thiazole-4(5H)-one；2-morpholin-4-yl-thiazol-4-one；2-morpholino-thiazol-4-one；2-Morpholino-thiazol-4-on；2-morpholin-4-yl-1,3-thiazol-4(5H)-one；2-morpholin-4-yl-1,3-thiazol-4-one
• CAS: 16781-67-2
• 化学式: C₇H₁₀N₂O₂S
• mdl: MFCD00758530
• 分子量: 186.235
• InChiKey: HKPOETYJKCUXBF-UHFFFAOYSA-N

物化性质

• 熔点：
  201-202 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• 沸点：
  315.1±52.0 °C(Predicted)
• 密度：
  1.52±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  67.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-吗啉-4-基-1,3-噻唑-4(5h)-酮 、 4-[2-(5-乙基-2-吡啶基)乙氧基]苯甲醛 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 5-{4-[2-(5-ethyl-pyridin-2-yl)ethoxy]benzylidene}-2-morpholin-4-yl-thiazol-4-one
  参考文献：
  名称：

  WO2008/75380

  摘要：

  公开号：
• 作为产物：
  描述：

  2-硫氰酸基乙酸乙酯 、 乙酸吗啉 反应 2.0h， 以54%的产率得到2-吗啉-4-基-1,3-噻唑-4(5h)-酮
  参考文献：
  名称：

  Zimmermann, T.; Fischer, G. W.; Olk, B., Journal fur praktische Chemie (Leipzig 1954), 1990, vol. 332, # 4, p. 540 - 546

  摘要：

  DOI：

文献信息

• Use of 2,5-Disubstituted Thiazol-4-One Derivatives in Drugs
  申请人：Frank Robert

  公开号：US20090215758A1

  公开（公告）日：2009-08-27

  The invention relates to 2,5-disubstituted thiazol-4-one derivatives and to their use in the production of drugs, to methods for producing them and to drugs containing said compounds.

  本发明涉及2,5-二取代噻唑-4-酮衍生物及其在药物生产中的应用，涉及其生产方法和含有该化合物的药物。
• Reactions of N,N-Disubstituted 5-Arylmethylidene-2-amino-thiazol-4(5H)-ones with CH Acids
  作者：Kamal A. Kandeel、Ali M. Youssef、Hany M. El-Bestawy、Mohamed T. Omar

  DOI：10.1007/s007060200092

  日期：2002.9.1

  N,N-Disubstituted 5-arylmethylidene-2-aminothiazol-4(5H)-ones reacted with diethyl malonate, ethyl benzoylacetate, acetylacetone, or cyclopentadiene in refluxing toluene and in presence of powdered sodium to give the respective 5-arylmethylidene-2'-amino-2,5'-bithiazolylidene-4,4'-dione derivatives in moderate yields. 5-Benzylidene-2-morpholin-4-yl-2-thiazol-4(5H)-one reacted with malononitrile in toluene and in presence of powdered sodium under mild conditions to afford the 1:1 adduct, benzylmalononitrile, and 2-morpholin-4-yl-2-thiazol-4(5H)-one. However, similar treatment of 5-(4-methoxyphenylmethylidene)-2-morpholin-4-yl-2-thiazol-4(5H)-one with malononitrile yielded the 2,5'-bithiazolylidene-4,4'-dione derivative together with 4-methoxyphenylmethylidene malononitrile. Treatment of 5-benzylidene- and 5-(4-methoxyphenylmethylidene)-2-morpholin-4-yl-2-thiazol-4(5H)-ones with 3-phenyl-4-oxo-2-thioxo-1,3-thiazolidine in refluxing toluene and in presence of powdered sodium produced 5-arylmethylidene-3-phenyl-4-oxo-2-thioxo-1,3-thiazolidines in good yields. The structures of all products were deduced from microanalytical and spectroscopic data, mechanistic details are discussed.
• A new application of rhodanine as a green sulfur transferring agent for a clean functional group interconversion of amide to thioamide using reusable MCM-41 mesoporous silica
  作者：Suman Ray、Asim Bhaumik、Arghya Dutta、Ray J. Butcher、Chhanda Mukhopadhyay

  DOI：10.1016/j.tetlet.2013.02.045

  日期：2013.4

  A novel thionation protocol for amide compounds, with the system rhodanine/secondary amine has been discovered. Clean and efficient synthesis of a variety of thioamides can be achieved through this simple and convenient method using MCM-41 mesoporous silica as an acid catalyst. For this purpose we have synthesized MCM-41 silica and characterized by using an array of sophisticated analytical techniques like BET, HR TEM, EDX, XRD, 29Si MAS NMR and FTIR. This reaction is therefore a very neat example of a functional group interconversion. (C) 2013 Elsevier Ltd. All rights reserved.
• DE930563
  申请人：——

  公开号：——

  公开（公告）日：——
• 2-SUBSTITUTED THIAZOLIDINONE AND OXAZOLIDINONE DERIVATIVES FOR THE INHIBITION OF PHOSPHATASES AND THE TREATMENT OF CANCER
  申请人：Incyte San Diego Incorporated

  公开号：EP1463718A1

  公开（公告）日：2004-10-06