[EN] LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS<br/>[FR] LIPIDES ET FORMULATIONS DE NANOPARTICULES DE LIPIDES POUR LA LIBÉRATION D'ACIDES NUCLÉIQUES
申请人:ACUITAS THERAPEUTICS INC
公开号:WO2017117528A1
公开(公告)日:2017-07-06
Compounds are provided having the following structure (I) or (II): or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, L, X, L, G1, G2, Z, a1, a2 and n are independently as defined herein for each of structures (I) and (II). Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
提供具有以下结构(I)或(II)的化合物:或其药学上可接受的盐、互变异构体或立体异构体,其中R、R1、R2、L、X、L、G1、G2、Z、a1、a2和n分别如本文所定义的用于结构(I)和(II)。还提供了将这些化合物用作脂质纳米粒子配方的组分以传递治疗剂、包含这些化合物的组合物以及其使用和制备方法。